Long-term follow-up of severely symptomatic women with adenomyoma treated with combination therapy
Objective: The aim of our study was to assess the long-term efficacy of conservative surgery combined with gonadotropin-releasing hormone agonist therapy for uterine adenomyoma. Materials and Methods: We carried out an uncontrolled descriptive study of 285 women who had symptomatic uterine adenomyom...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-03-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S102845591300017X |
| _version_ | 1818970753219952640 |
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| author | Wei-Min Liu Ching-Hui Chen Li-Hsuan Chiu Chii-Ruey Tzeng |
| author_facet | Wei-Min Liu Ching-Hui Chen Li-Hsuan Chiu Chii-Ruey Tzeng |
| author_sort | Wei-Min Liu |
| collection | DOAJ |
| description | Objective: The aim of our study was to assess the long-term efficacy of conservative surgery combined with gonadotropin-releasing hormone agonist therapy for uterine adenomyoma.
Materials and Methods: We carried out an uncontrolled descriptive study of 285 women who had symptomatic uterine adenomyoma. A total of 186 women with pathologically proven adenomyoma underwent ultramini-laparoscopic adenomyomectomy and a 6-month course of goserelin acetate treatment, and were evaluated semi-annually during a follow-up period of at least 3 years.
Results: Patient scores for dysmenorrhea using a self-reported six-point verbal numeric rating scale significantly declined compared with the baseline assessment, from 3.84 ± 0.65 to 0.33 ± 0.57, 0.52 ± 0.86, and 0.88 ± 1.29 at the end of the 1-, 2-, and 3-year follow-up visits, respectively (p < 0.001). Similar reductions were observed for analgesic usage scores. Menorrhagia scores significantly decreased compared with the baseline assessment, from 3.45 ± 1.46 to 0.42 ± 0.59, 0.65 ± 0.83, and 1.1 ± 1.34 at the end of the 1-, 2-, and 3-year follow-up visits, respectively (p < 0.001).
Conclusion: Combination therapy for adenomyoma provides an effective treatment option for long-term symptom control and uterine preservation in severely symptomatic women for whom previous long-term drug therapy has failed or proven to be intolerable. |
| first_indexed | 2024-12-20T14:41:29Z |
| format | Article |
| id | doaj.art-6863feaf622745be9316cd95a4c36f8c |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-20T14:41:29Z |
| publishDate | 2013-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-6863feaf622745be9316cd95a4c36f8c2022-12-21T19:37:16ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592013-03-01521858910.1016/j.tjog.2012.12.002Long-term follow-up of severely symptomatic women with adenomyoma treated with combination therapyWei-Min Liu0Ching-Hui Chen1Li-Hsuan Chiu2Chii-Ruey Tzeng3Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, TaiwanDepartment of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanObjective: The aim of our study was to assess the long-term efficacy of conservative surgery combined with gonadotropin-releasing hormone agonist therapy for uterine adenomyoma. Materials and Methods: We carried out an uncontrolled descriptive study of 285 women who had symptomatic uterine adenomyoma. A total of 186 women with pathologically proven adenomyoma underwent ultramini-laparoscopic adenomyomectomy and a 6-month course of goserelin acetate treatment, and were evaluated semi-annually during a follow-up period of at least 3 years. Results: Patient scores for dysmenorrhea using a self-reported six-point verbal numeric rating scale significantly declined compared with the baseline assessment, from 3.84 ± 0.65 to 0.33 ± 0.57, 0.52 ± 0.86, and 0.88 ± 1.29 at the end of the 1-, 2-, and 3-year follow-up visits, respectively (p < 0.001). Similar reductions were observed for analgesic usage scores. Menorrhagia scores significantly decreased compared with the baseline assessment, from 3.45 ± 1.46 to 0.42 ± 0.59, 0.65 ± 0.83, and 1.1 ± 1.34 at the end of the 1-, 2-, and 3-year follow-up visits, respectively (p < 0.001). Conclusion: Combination therapy for adenomyoma provides an effective treatment option for long-term symptom control and uterine preservation in severely symptomatic women for whom previous long-term drug therapy has failed or proven to be intolerable.http://www.sciencedirect.com/science/article/pii/S102845591300017Xadenomyomaconservative surgerygonadotropin-releasing hormone agonist |
| spellingShingle | Wei-Min Liu Ching-Hui Chen Li-Hsuan Chiu Chii-Ruey Tzeng Long-term follow-up of severely symptomatic women with adenomyoma treated with combination therapy Taiwanese Journal of Obstetrics & Gynecology adenomyoma conservative surgery gonadotropin-releasing hormone agonist |
| title | Long-term follow-up of severely symptomatic women with adenomyoma treated with combination therapy |
| title_full | Long-term follow-up of severely symptomatic women with adenomyoma treated with combination therapy |
| title_fullStr | Long-term follow-up of severely symptomatic women with adenomyoma treated with combination therapy |
| title_full_unstemmed | Long-term follow-up of severely symptomatic women with adenomyoma treated with combination therapy |
| title_short | Long-term follow-up of severely symptomatic women with adenomyoma treated with combination therapy |
| title_sort | long term follow up of severely symptomatic women with adenomyoma treated with combination therapy |
| topic | adenomyoma conservative surgery gonadotropin-releasing hormone agonist |
| url | http://www.sciencedirect.com/science/article/pii/S102845591300017X |
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