Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity
ABSTRACT Purpose: We aimed to investigate the antioxidant activity of nebivolol against possible damage to the ovarian tissue due to the application of deltamethrin as a toxic agent, by evaluating histopathological proliferating cell nuclear antigen (PCNA) and tumor necrosis factor-alpha (TNF-α) si...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2023-10-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502023000100241&lng=en&tlng=en |
| _version_ | 1797652385645985792 |
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| author | Serap Otçu Engin Deveci Çağdaş Özgökçe Görkem Tutal Gürsoy Mehmet Cudi Tuncer |
| author_facet | Serap Otçu Engin Deveci Çağdaş Özgökçe Görkem Tutal Gürsoy Mehmet Cudi Tuncer |
| author_sort | Serap Otçu |
| collection | DOAJ |
| description | ABSTRACT Purpose: We aimed to investigate the antioxidant activity of nebivolol against possible damage to the ovarian tissue due to the application of deltamethrin as a toxic agent, by evaluating histopathological proliferating cell nuclear antigen (PCNA) and tumor necrosis factor-alpha (TNF-α) signal molecules immunohistochemically. Methods: The animals were divided into three groups as control, deltamethrin and deltamethrin + nebivolol groups. Vaginal smears were taken after the animals were mated and detected on the first day of pregnancy. After the sixth day, deltamethrin (0.5 mL of 30 mg/kg BW undiluted ULV), and 2 mL of sterile nebivolol solution were administered intraperitoneally every day for 6-21 periods. After routine histopathological follow-up, the ovarian tissue was stained with hematoxylin and eosin stain. Results: Control group showed normal histology of ovarium. In deltamethrin group, hyperplasic cells, degenerative follicles, pyknotic nuclei, inflammation and hemorrhagic areas were observed. Nebivolol treatment restored these pathologies. Deltamethrin treatment increased TNF-α and PCNA reaction. However, nebivolol decreased the expression. Conclusions: It was thought that deltamethrin toxicity adversely affected follicle development by inducing degeneration and apoptotic process in preantral and antra follicle cells, and nebivolol administration might reduce inflammation and slow down the apoptotic signal in the nuclear phase and regulate reorganization. |
| first_indexed | 2024-03-11T16:29:10Z |
| format | Article |
| id | doaj.art-68647d734b1f4ebb8da8419ca422605a |
| institution | Directory Open Access Journal |
| issn | 1678-2674 |
| language | English |
| last_indexed | 2024-03-11T16:29:10Z |
| publishDate | 2023-10-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-68647d734b1f4ebb8da8419ca422605a2023-10-24T07:47:58ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira1678-26742023-10-013810.1590/acb385423Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicitySerap Otçuhttps://orcid.org/0000-0001-5124-9031Engin Devecihttps://orcid.org/0000-0002-2353-1184Çağdaş Özgökçehttps://orcid.org/0000-0003-4960-4625Görkem Tutal Gürsoyhttps://orcid.org/0000-0002-1990-1162Mehmet Cudi Tuncerhttps://orcid.org/0000-0001-7317-5467ABSTRACT Purpose: We aimed to investigate the antioxidant activity of nebivolol against possible damage to the ovarian tissue due to the application of deltamethrin as a toxic agent, by evaluating histopathological proliferating cell nuclear antigen (PCNA) and tumor necrosis factor-alpha (TNF-α) signal molecules immunohistochemically. Methods: The animals were divided into three groups as control, deltamethrin and deltamethrin + nebivolol groups. Vaginal smears were taken after the animals were mated and detected on the first day of pregnancy. After the sixth day, deltamethrin (0.5 mL of 30 mg/kg BW undiluted ULV), and 2 mL of sterile nebivolol solution were administered intraperitoneally every day for 6-21 periods. After routine histopathological follow-up, the ovarian tissue was stained with hematoxylin and eosin stain. Results: Control group showed normal histology of ovarium. In deltamethrin group, hyperplasic cells, degenerative follicles, pyknotic nuclei, inflammation and hemorrhagic areas were observed. Nebivolol treatment restored these pathologies. Deltamethrin treatment increased TNF-α and PCNA reaction. However, nebivolol decreased the expression. Conclusions: It was thought that deltamethrin toxicity adversely affected follicle development by inducing degeneration and apoptotic process in preantral and antra follicle cells, and nebivolol administration might reduce inflammation and slow down the apoptotic signal in the nuclear phase and regulate reorganization.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502023000100241&lng=en&tlng=enOvaryNebivololProliferating Cell Nuclear AntigenTumor Necrosis Factor-alpha |
| spellingShingle | Serap Otçu Engin Deveci Çağdaş Özgökçe Görkem Tutal Gürsoy Mehmet Cudi Tuncer Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity Acta Cirúrgica Brasileira Ovary Nebivolol Proliferating Cell Nuclear Antigen Tumor Necrosis Factor-alpha |
| title | Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity |
| title_full | Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity |
| title_fullStr | Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity |
| title_full_unstemmed | Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity |
| title_short | Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity |
| title_sort | protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity |
| topic | Ovary Nebivolol Proliferating Cell Nuclear Antigen Tumor Necrosis Factor-alpha |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502023000100241&lng=en&tlng=en |
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