ACC Theta Improves Hippocampal Contextual Processing during Remote Recall
Summary: Consolidation studies show that, over time, memory recall becomes independent of the medial temporal lobes. Multiple lines of research show that the medial frontal cortex, including the anterior cingulate cortex (ACC), is involved with contextual information processing and remote recall. We...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-05-01
|
| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719305601 |
| _version_ | 1818267305975480320 |
|---|---|
| author | Ryan A. Wirt James M. Hyman |
| author_facet | Ryan A. Wirt James M. Hyman |
| author_sort | Ryan A. Wirt |
| collection | DOAJ |
| description | Summary: Consolidation studies show that, over time, memory recall becomes independent of the medial temporal lobes. Multiple lines of research show that the medial frontal cortex, including the anterior cingulate cortex (ACC), is involved with contextual information processing and remote recall. We hypothesize that interactions between the ACC and hippocampal area CA1 will change as memories became more remote. Animals are re-exposed to multiple environments at different retention intervals. During remote recall, ACC-CA1 theta coherence increases, with the ACC leading area CA1. ACC theta regulates unit spike timing, gamma oscillations, and ensemble and single-neuron information coding in CA1. Over the course of consolidation, the strength and prevalence of ACC theta modulation grow, leading to richer environmental context representations in CA1. These data are consistent with the transference of contextual memory dependence to the ACC and indicate that remote memories are retrieved via ACC-driven oscillatory coupling with CA1. : Over time, contextual memories become dependent on the ACC for retrieval. Wirt and Hyman found that theta-mediated interactions between ACC and CA1 increase for remote recall. Communication from the ACC to CA1 modulates neural oscillations and unit spiking, leading to enhanced CA1 contextual information. Keywords: anterior cingulate cortex, hippocampus, prefrontal cortex, population analysis, consolidation, cross frequency coupling, gamma, oscillations, context, medial frontal |
| first_indexed | 2024-12-12T20:20:30Z |
| format | Article |
| id | doaj.art-6864b7cedf204d488f0b74e8e965e087 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-12T20:20:30Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-6864b7cedf204d488f0b74e8e965e0872022-12-22T00:13:17ZengElsevierCell Reports2211-12472019-05-0127823132327.e4ACC Theta Improves Hippocampal Contextual Processing during Remote RecallRyan A. Wirt0James M. Hyman1Department of Psychology, University of Nevada Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV 89154, USADepartment of Psychology, University of Nevada Las Vegas, 4505 S. Maryland Parkway, MS 5030, Las Vegas, NV 89154, USA; Corresponding authorSummary: Consolidation studies show that, over time, memory recall becomes independent of the medial temporal lobes. Multiple lines of research show that the medial frontal cortex, including the anterior cingulate cortex (ACC), is involved with contextual information processing and remote recall. We hypothesize that interactions between the ACC and hippocampal area CA1 will change as memories became more remote. Animals are re-exposed to multiple environments at different retention intervals. During remote recall, ACC-CA1 theta coherence increases, with the ACC leading area CA1. ACC theta regulates unit spike timing, gamma oscillations, and ensemble and single-neuron information coding in CA1. Over the course of consolidation, the strength and prevalence of ACC theta modulation grow, leading to richer environmental context representations in CA1. These data are consistent with the transference of contextual memory dependence to the ACC and indicate that remote memories are retrieved via ACC-driven oscillatory coupling with CA1. : Over time, contextual memories become dependent on the ACC for retrieval. Wirt and Hyman found that theta-mediated interactions between ACC and CA1 increase for remote recall. Communication from the ACC to CA1 modulates neural oscillations and unit spiking, leading to enhanced CA1 contextual information. Keywords: anterior cingulate cortex, hippocampus, prefrontal cortex, population analysis, consolidation, cross frequency coupling, gamma, oscillations, context, medial frontalhttp://www.sciencedirect.com/science/article/pii/S2211124719305601 |
| spellingShingle | Ryan A. Wirt James M. Hyman ACC Theta Improves Hippocampal Contextual Processing during Remote Recall Cell Reports |
| title | ACC Theta Improves Hippocampal Contextual Processing during Remote Recall |
| title_full | ACC Theta Improves Hippocampal Contextual Processing during Remote Recall |
| title_fullStr | ACC Theta Improves Hippocampal Contextual Processing during Remote Recall |
| title_full_unstemmed | ACC Theta Improves Hippocampal Contextual Processing during Remote Recall |
| title_short | ACC Theta Improves Hippocampal Contextual Processing during Remote Recall |
| title_sort | acc theta improves hippocampal contextual processing during remote recall |
| url | http://www.sciencedirect.com/science/article/pii/S2211124719305601 |
| work_keys_str_mv | AT ryanawirt accthetaimproveshippocampalcontextualprocessingduringremoterecall AT jamesmhyman accthetaimproveshippocampalcontextualprocessingduringremoterecall |