Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

Abstract 8-Oxoguanine DNA glycosylase (OGG1) initiates base excision repair of the oxidative DNA damage product 8-oxoguanine. OGG1 is bifunctional; catalyzing glycosyl bond cleavage, followed by phosphodiester backbone incision via a β-elimination apurinic lyase reaction. The product from the glycos...

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Bibliographic Details
Main Authors: Gaochao Tian, Steven R. Katchur, Yong Jiang, Jacques Briand, Michael Schaber, Constantine Kreatsoulas, Benjamin Schwartz, Sara Thrall, Alicia M. Davis, Sam Duvall, Brett A. Kaufman, William L. Rumsey
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18878-2

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