CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology

CRISPR-mediated rapid generation of neural cell-specific knockout mice facilitates research in neurophysiology and pathology

Inducible conditional knockout mice are important tools for studying gene function and disease therapy, but their generation is costly and time-consuming. We introduced clustered regularly interspaced short palindromic repeats (CRISPR) and Cre into an LSL-Cas9 transgene-carrying mouse line by using...

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Bibliographic Details
Main Authors: Dan Xiao, Weifeng Zhang, Qing Wang, Xing Li, Yuan Zhang, Javad Rasouli, Giacomo Casella, Bogoljub Ciric, Mark Curtis, Abdolmohamad Rostami, Guang-Xian Zhang
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
CRISPR
Conditional knockout
AAV PHP.eB
Neural-specific knockout
Multiple sclerosis
Knockout mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000279

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