Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases
Neuronal death and inflammatory response are two common pathological hallmarks of acute central nervous system injury and chronic degenerative disorders, both of which are closely related to cognitive and motor dysfunction associated with various neurological diseases. Neurological diseases are high...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.794580/full |
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| author | Mingming Shi Mingming Shi Mingming Shi Yan Chai Yan Chai Jianning Zhang Jianning Zhang Jianning Zhang Xin Chen Xin Chen Xin Chen |
| author_facet | Mingming Shi Mingming Shi Mingming Shi Yan Chai Yan Chai Jianning Zhang Jianning Zhang Jianning Zhang Xin Chen Xin Chen Xin Chen |
| author_sort | Mingming Shi |
| collection | DOAJ |
| description | Neuronal death and inflammatory response are two common pathological hallmarks of acute central nervous system injury and chronic degenerative disorders, both of which are closely related to cognitive and motor dysfunction associated with various neurological diseases. Neurological diseases are highly heterogeneous; however, they share a common pathogenesis, that is, the aberrant accumulation of misfolded/unfolded proteins within the endoplasmic reticulum (ER). Fortunately, the cell has intrinsic quality control mechanisms to maintain the proteostasis network, such as chaperone-mediated folding and ER-associated degradation. However, when these control mechanisms fail, misfolded/unfolded proteins accumulate in the ER lumen and contribute to ER stress. ER stress has been implicated in nearly all neurological diseases. ER stress initiates the unfolded protein response to restore proteostasis, and if the damage is irreversible, it elicits intracellular cascades of death and inflammation. With the growing appreciation of a functional association between ER stress and neurological diseases and with the improved understanding of the multiple underlying molecular mechanisms, pharmacological and genetic targeting of ER stress are beginning to emerge as therapeutic approaches for neurological diseases. |
| first_indexed | 2024-12-20T07:25:23Z |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-20T07:25:23Z |
| publishDate | 2022-01-01 |
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| series | Frontiers in Immunology |
| spelling | doaj.art-686aa6c87f6842b685914f75e990f15e2022-12-21T19:48:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-01-011210.3389/fimmu.2021.794580794580Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological DiseasesMingming Shi0Mingming Shi1Mingming Shi2Yan Chai3Yan Chai4Jianning Zhang5Jianning Zhang6Jianning Zhang7Xin Chen8Xin Chen9Xin Chen10Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Neurological Institute, Key Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, ChinaTianjin Neurological Institute, Key Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Neurological Institute, Key Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, ChinaTianjin Neurological Institute, Key Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, ChinaNeuronal death and inflammatory response are two common pathological hallmarks of acute central nervous system injury and chronic degenerative disorders, both of which are closely related to cognitive and motor dysfunction associated with various neurological diseases. Neurological diseases are highly heterogeneous; however, they share a common pathogenesis, that is, the aberrant accumulation of misfolded/unfolded proteins within the endoplasmic reticulum (ER). Fortunately, the cell has intrinsic quality control mechanisms to maintain the proteostasis network, such as chaperone-mediated folding and ER-associated degradation. However, when these control mechanisms fail, misfolded/unfolded proteins accumulate in the ER lumen and contribute to ER stress. ER stress has been implicated in nearly all neurological diseases. ER stress initiates the unfolded protein response to restore proteostasis, and if the damage is irreversible, it elicits intracellular cascades of death and inflammation. With the growing appreciation of a functional association between ER stress and neurological diseases and with the improved understanding of the multiple underlying molecular mechanisms, pharmacological and genetic targeting of ER stress are beginning to emerge as therapeutic approaches for neurological diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2021.794580/fullneuronal deathinflammatory responseneurological diseasesendoplasmic reticulum stressproteostasisunfolded protein response |
| spellingShingle | Mingming Shi Mingming Shi Mingming Shi Yan Chai Yan Chai Jianning Zhang Jianning Zhang Jianning Zhang Xin Chen Xin Chen Xin Chen Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases Frontiers in Immunology neuronal death inflammatory response neurological diseases endoplasmic reticulum stress proteostasis unfolded protein response |
| title | Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases |
| title_full | Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases |
| title_fullStr | Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases |
| title_full_unstemmed | Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases |
| title_short | Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases |
| title_sort | endoplasmic reticulum stress associated neuronal death and innate immune response in neurological diseases |
| topic | neuronal death inflammatory response neurological diseases endoplasmic reticulum stress proteostasis unfolded protein response |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.794580/full |
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