Carbonic Anhydrases: Role in pH Control and Cancer
The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new therapeutic targets. This includes an understan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-02-01
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| Series: | Metabolites |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2218-1989/8/1/19 |
| _version_ | 1819053173214543872 |
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| author | Mam Y. Mboge Brian P. Mahon Robert McKenna Susan C. Frost |
| author_facet | Mam Y. Mboge Brian P. Mahon Robert McKenna Susan C. Frost |
| author_sort | Mam Y. Mboge |
| collection | DOAJ |
| description | The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new therapeutic targets. This includes an understanding of the role pH plays in primary tumor cells, and the regulatory factors that permit cancer cells to thrive. Over the last decade, carbonic anhydrases (CAs) have been shown to be important mediators of tumor cell pH by modulating the bicarbonate and proton concentrations for cell survival and proliferation. This has prompted an effort to inhibit specific CA isoforms, as an anti-cancer therapeutic strategy. Of the 12 active CA isoforms, two, CA IX and XII, have been considered anti-cancer targets. However, other CA isoforms also show similar activity and tissue distribution in cancers and have not been considered as therapeutic targets for cancer treatment. In this review, we consider all the CA isoforms and their possible role in tumors and their potential as targets for cancer therapy. |
| first_indexed | 2024-12-21T12:31:31Z |
| format | Article |
| id | doaj.art-686bc23d29e34ed0a5d2a3ed2902e301 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-12-21T12:31:31Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-686bc23d29e34ed0a5d2a3ed2902e3012022-12-21T19:04:02ZengMDPI AGMetabolites2218-19892018-02-01811910.3390/metabo8010019metabo8010019Carbonic Anhydrases: Role in pH Control and CancerMam Y. Mboge0Brian P. Mahon1Robert McKenna2Susan C. Frost3University of Florida, College of Medicine, Department of Biochemistry and Molecular Biology, P.O. Box 100245, Gainesville, FL 32610, USAUniversity of Florida, College of Medicine, Department of Biochemistry and Molecular Biology, P.O. Box 100245, Gainesville, FL 32610, USAUniversity of Florida, College of Medicine, Department of Biochemistry and Molecular Biology, P.O. Box 100245, Gainesville, FL 32610, USAUniversity of Florida, College of Medicine, Department of Biochemistry and Molecular Biology, P.O. Box 100245, Gainesville, FL 32610, USAThe pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new therapeutic targets. This includes an understanding of the role pH plays in primary tumor cells, and the regulatory factors that permit cancer cells to thrive. Over the last decade, carbonic anhydrases (CAs) have been shown to be important mediators of tumor cell pH by modulating the bicarbonate and proton concentrations for cell survival and proliferation. This has prompted an effort to inhibit specific CA isoforms, as an anti-cancer therapeutic strategy. Of the 12 active CA isoforms, two, CA IX and XII, have been considered anti-cancer targets. However, other CA isoforms also show similar activity and tissue distribution in cancers and have not been considered as therapeutic targets for cancer treatment. In this review, we consider all the CA isoforms and their possible role in tumors and their potential as targets for cancer therapy.http://www.mdpi.com/2218-1989/8/1/19tumorspHcarbonic anhydrasesmetalloenzymescarbonic anhydrase IXcarbonic anhydrase XIIcancer therapeuticsmetabolismtumor microenvironmentdrug discovery |
| spellingShingle | Mam Y. Mboge Brian P. Mahon Robert McKenna Susan C. Frost Carbonic Anhydrases: Role in pH Control and Cancer Metabolites tumors pH carbonic anhydrases metalloenzymes carbonic anhydrase IX carbonic anhydrase XII cancer therapeutics metabolism tumor microenvironment drug discovery |
| title | Carbonic Anhydrases: Role in pH Control and Cancer |
| title_full | Carbonic Anhydrases: Role in pH Control and Cancer |
| title_fullStr | Carbonic Anhydrases: Role in pH Control and Cancer |
| title_full_unstemmed | Carbonic Anhydrases: Role in pH Control and Cancer |
| title_short | Carbonic Anhydrases: Role in pH Control and Cancer |
| title_sort | carbonic anhydrases role in ph control and cancer |
| topic | tumors pH carbonic anhydrases metalloenzymes carbonic anhydrase IX carbonic anhydrase XII cancer therapeutics metabolism tumor microenvironment drug discovery |
| url | http://www.mdpi.com/2218-1989/8/1/19 |
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