Carbonic Anhydrases: Role in pH Control and Cancer

Carbonic Anhydrases: Role in pH Control and Cancer

The pH of the tumor microenvironment drives the metastatic phenotype and chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH-dependent phenomenon will lead to improved drug delivery and allow the identification of new therapeutic targets. This includes an understan...

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Bibliographic Details
Main Authors:	Mam Y. Mboge, Brian P. Mahon, Robert McKenna, Susan C. Frost
Format:	Article
Language:	English
Published:	MDPI AG 2018-02-01
Series:	Metabolites
Subjects:	tumors pH carbonic anhydrases metalloenzymes carbonic anhydrase IX carbonic anhydrase XII cancer therapeutics metabolism tumor microenvironment drug discovery
Online Access:	http://www.mdpi.com/2218-1989/8/1/19

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