Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions

Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions

Objective(s): Non-alcoholic steatohepatitis (NASH) is defined by steatosis and inflammation in the hepatocytes, which can progress to cirrhosis and possibly hepatocellular carcinoma. However, current treatments are not entirely effective. Allantoin is one of the principal compounds in many plants an...

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Bibliographic Details
Main Authors: Tahereh Komeili Movahhed, Azam Moslehi, Mohammad Golchoob, shima ababzadeh
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2019-07-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Allantoin
Liver
Non-alcoholic steatohepatitis
PPARα
SREBP1c
Steatosis
Online Access:http://ijbms.mums.ac.ir/article_13009_2f19f6202f8dedda2bc0f4cd4dc175a4.pdf

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