Single-nucleotide polymorphism rs1761667 in the CD36 gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjects
Obese subjects have shown a preference for dietary lipids. A recent collection of evidence has proposed that a variant in the CD36 gene plays a significant role in this pathway. We assessed the association between the orosensory detection of a long-chain fatty acid, i.e. oleic acid (OA), and genetic...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2020-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S204867902000018X/type/journal_article |
| _version_ | 1827994492887629824 |
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| author | Habiba Bajit O. Ait Si Mohammed Y. Guennoun S. Benaich E. Bouaiti H. Belghiti M. Mrabet E. M. Elfahime N. E. El Haloui N. Saeid K. El Kari A. Hichami N. A. Khan H. Benkirane H. Aguenaou |
| author_facet | Habiba Bajit O. Ait Si Mohammed Y. Guennoun S. Benaich E. Bouaiti H. Belghiti M. Mrabet E. M. Elfahime N. E. El Haloui N. Saeid K. El Kari A. Hichami N. A. Khan H. Benkirane H. Aguenaou |
| author_sort | Habiba Bajit |
| collection | DOAJ |
| description | Obese subjects have shown a preference for dietary lipids. A recent collection of evidence has proposed that a variant in the CD36 gene plays a significant role in this pathway. We assessed the association between the orosensory detection of a long-chain fatty acid, i.e. oleic acid (OA), and genetic polymorphism of the lipid taste sensor CD36 in obese and normal-weight subjects. Adult participants were recruited in the fasting condition. They were invited to fat taste perception sessions, using emulsions containing OA and according to the three-alternative forced-choice (3-AFC) method. Genomic DNA was used to determine the polymorphism (SNP rs 1761667) of the CD36 gene. Obese (n 50; BMI 34⋅97 (sd 4⋅02) kg/m2) exhibited a significantly higher oral detection threshold for OA (3⋅056 (sd 3⋅53) mmol/l) than did the normal-weight (n 50; BMI 22⋅16 (sd 1⋅81) kg/m2) participants (1⋅20 (sd 3⋅23) mmol/l; P = 0⋅007). There was a positive correlation between OA detection thresholds and BMI in all subjects; evenly with body fat percentage (BF%). AA genotype was more frequent in the obese group than normal-weight group. OA detection thresholds were much higher for AA and AG genotypes in obese subjects compared with normal-weight participants. Higher oral detection thresholds for fatty acid taste are related to BMI, BF% and not always to CD36 genotype. |
| first_indexed | 2024-04-10T04:41:46Z |
| format | Article |
| id | doaj.art-686d32823d304727a6901892c425115f |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:41:46Z |
| publishDate | 2020-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-686d32823d304727a6901892c425115f2023-03-09T12:39:11ZengCambridge University PressJournal of Nutritional Science2048-67902020-01-01910.1017/jns.2020.18Single-nucleotide polymorphism rs1761667 in the CD36 gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjectsHabiba Bajit0https://orcid.org/0000-0001-5564-2666O. Ait Si Mohammed1Y. Guennoun2S. Benaich3E. Bouaiti4H. Belghiti5M. Mrabet6E. M. Elfahime7N. E. El Haloui8N. Saeid9K. El Kari10A. Hichami11N. A. Khan12https://orcid.org/0000-0002-8930-9332H. Benkirane13H. Aguenaou14Ibn Tofaïl University – CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), 14000Kenitra, MoroccoResearch Team in Neurology and Neurogenetics, Genomics Center of Human Pathologies, Faculty of Medicine and Pharmacy, Mohammed 5th University, 10100Rabat, MoroccoIbn Tofaïl University – CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), 14000Kenitra, MoroccoPhysiology and Physiopathology Research Team, Research Centre of Human Pathologies Genomics, Faculty of Sciences, Mohammed 5th University in Rabat, 4, Avenue Ibn Battouta BP 1014, Rabat, MoroccoLaboratory of Epidemiology and Clinical Research, Faculty of Medicine, Mohammed 5th University, 10100Rabat, MoroccoNutrition Unit Hygiene and Collectivity Medicine Ward, Military Hospital of Instruction Mohammed 5th, 10110Rabat, MoroccoHPC Ain Sbaa Groupe Akdital, Casablanca, MoroccoUnités d'Appui Techniques à la Recherche Scientifique (UATRS), Plateforme Biologie Moléculaire et Génomique Fonctionnelle, Centre National pour la Recherche Scientifique et Technique (CNRST), 10102Rabat, MoroccoIbn Tofaïl University – CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), 14000Kenitra, MoroccoIbn Tofaïl University – CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), 14000Kenitra, MoroccoIbn Tofaïl University – CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), 14000Kenitra, MoroccoPhysiologie de la Nutrition & Toxicologie, INSERM UMR 1231, Université de Bourgogne, Faculté des Sciences de la Vie, 21000Dijon, FrancePhysiologie de la Nutrition & Toxicologie, INSERM UMR 1231, Université de Bourgogne, Faculté des Sciences de la Vie, 21000Dijon, FranceIbn Tofaïl University – CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), 14000Kenitra, MoroccoIbn Tofaïl University – CNESTEN, Joint Research Unit in Nutrition and Food, Regional Designated Center of Nutrition (AFRA/IAEA), 14000Kenitra, MoroccoObese subjects have shown a preference for dietary lipids. A recent collection of evidence has proposed that a variant in the CD36 gene plays a significant role in this pathway. We assessed the association between the orosensory detection of a long-chain fatty acid, i.e. oleic acid (OA), and genetic polymorphism of the lipid taste sensor CD36 in obese and normal-weight subjects. Adult participants were recruited in the fasting condition. They were invited to fat taste perception sessions, using emulsions containing OA and according to the three-alternative forced-choice (3-AFC) method. Genomic DNA was used to determine the polymorphism (SNP rs 1761667) of the CD36 gene. Obese (n 50; BMI 34⋅97 (sd 4⋅02) kg/m2) exhibited a significantly higher oral detection threshold for OA (3⋅056 (sd 3⋅53) mmol/l) than did the normal-weight (n 50; BMI 22⋅16 (sd 1⋅81) kg/m2) participants (1⋅20 (sd 3⋅23) mmol/l; P = 0⋅007). There was a positive correlation between OA detection thresholds and BMI in all subjects; evenly with body fat percentage (BF%). AA genotype was more frequent in the obese group than normal-weight group. OA detection thresholds were much higher for AA and AG genotypes in obese subjects compared with normal-weight participants. Higher oral detection thresholds for fatty acid taste are related to BMI, BF% and not always to CD36 genotype.https://www.cambridge.org/core/product/identifier/S204867902000018X/type/journal_articleObesityBMIFat taste sensitivityOleic acid detection thresholdsCD36SNP rs1761667 |
| spellingShingle | Habiba Bajit O. Ait Si Mohammed Y. Guennoun S. Benaich E. Bouaiti H. Belghiti M. Mrabet E. M. Elfahime N. E. El Haloui N. Saeid K. El Kari A. Hichami N. A. Khan H. Benkirane H. Aguenaou Single-nucleotide polymorphism rs1761667 in the CD36 gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjects Journal of Nutritional Science Obesity BMI Fat taste sensitivity Oleic acid detection thresholds CD36 SNP rs1761667 |
| title | Single-nucleotide polymorphism rs1761667 in the CD36 gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjects |
| title_full | Single-nucleotide polymorphism rs1761667 in the CD36 gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjects |
| title_fullStr | Single-nucleotide polymorphism rs1761667 in the CD36 gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjects |
| title_full_unstemmed | Single-nucleotide polymorphism rs1761667 in the CD36 gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjects |
| title_short | Single-nucleotide polymorphism rs1761667 in the CD36 gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjects |
| title_sort | single nucleotide polymorphism rs1761667 in the cd36 gene is associated with orosensory perception of a fatty acid in obese and normal weight moroccan subjects |
| topic | Obesity BMI Fat taste sensitivity Oleic acid detection thresholds CD36 SNP rs1761667 |
| url | https://www.cambridge.org/core/product/identifier/S204867902000018X/type/journal_article |
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