Indeterminate Cell Histiocytosis: A Case Report
Indeterminate cell histiocytosis is a rare neoplasm composed of cells with mixed characteristics of Langerhans cells and non-Langerhans cells. An otherwise healthy, 36-year-old woman presented with asymptomatic generalized papules and nodules that had appeared on all four extremities, the trunk, and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X09700804 |
| _version_ | 1818150510728839168 |
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| author | Chun-Hua Wang Gwo-Shing Chen |
| author_facet | Chun-Hua Wang Gwo-Shing Chen |
| author_sort | Chun-Hua Wang |
| collection | DOAJ |
| description | Indeterminate cell histiocytosis is a rare neoplasm composed of cells with mixed characteristics of Langerhans cells and non-Langerhans cells. An otherwise healthy, 36-year-old woman presented with asymptomatic generalized papules and nodules that had appeared on all four extremities, the trunk, and cheeks in the previous 6 months. The lesions were firm, painless, non-pruritic, and slightly flesh-yellow or reddish-brown in color. Histopathologic, immunohistochemical examination and electron microscopic studies showed characteristic findings of indeterminate cell histiocytosis: diffuse proliferative histiocytes infiltrating the dermis without epidermotropism or atypia; neoplastic cells expressing markers characteristic of both Langerhans cells (CD1a, S-100) and focal monocytes/macrophages (Factor XIIIa, CD68); and no Birbeck granules within the cytoplasm of the neoplastic cells. Flow cytometry revealed more CD34+ cells in the peripheral blood of the patient than in peripheral blood from a control. Interestingly, the patient responded favorably to psoralen ultraviolet A-range treatment. Herein, we present this case and review the literature. |
| first_indexed | 2024-12-11T13:24:05Z |
| format | Article |
| id | doaj.art-686d665f985a43caa2b5dc70656436c4 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-11T13:24:05Z |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-686d665f985a43caa2b5dc70656436c42022-12-22T01:05:38ZengWileyKaohsiung Journal of Medical Sciences1607-551X2004-01-01201242910.1016/S1607-551X(09)70080-4Indeterminate Cell Histiocytosis: A Case ReportChun-Hua WangGwo-Shing ChenIndeterminate cell histiocytosis is a rare neoplasm composed of cells with mixed characteristics of Langerhans cells and non-Langerhans cells. An otherwise healthy, 36-year-old woman presented with asymptomatic generalized papules and nodules that had appeared on all four extremities, the trunk, and cheeks in the previous 6 months. The lesions were firm, painless, non-pruritic, and slightly flesh-yellow or reddish-brown in color. Histopathologic, immunohistochemical examination and electron microscopic studies showed characteristic findings of indeterminate cell histiocytosis: diffuse proliferative histiocytes infiltrating the dermis without epidermotropism or atypia; neoplastic cells expressing markers characteristic of both Langerhans cells (CD1a, S-100) and focal monocytes/macrophages (Factor XIIIa, CD68); and no Birbeck granules within the cytoplasm of the neoplastic cells. Flow cytometry revealed more CD34+ cells in the peripheral blood of the patient than in peripheral blood from a control. Interestingly, the patient responded favorably to psoralen ultraviolet A-range treatment. Herein, we present this case and review the literature.http://www.sciencedirect.com/science/article/pii/S1607551X09700804indeterminate cell histiocytosis |
| spellingShingle | Chun-Hua Wang Gwo-Shing Chen Indeterminate Cell Histiocytosis: A Case Report Kaohsiung Journal of Medical Sciences indeterminate cell histiocytosis |
| title | Indeterminate Cell Histiocytosis: A Case Report |
| title_full | Indeterminate Cell Histiocytosis: A Case Report |
| title_fullStr | Indeterminate Cell Histiocytosis: A Case Report |
| title_full_unstemmed | Indeterminate Cell Histiocytosis: A Case Report |
| title_short | Indeterminate Cell Histiocytosis: A Case Report |
| title_sort | indeterminate cell histiocytosis a case report |
| topic | indeterminate cell histiocytosis |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X09700804 |
| work_keys_str_mv | AT chunhuawang indeterminatecellhistiocytosisacasereport AT gwoshingchen indeterminatecellhistiocytosisacasereport |