An Original and Efficient Antibiotic Adjuvant Strategy to Enhance the Activity of Macrolide Antibiotics against Gram-Negative Resistant Strains
Gram-negative bacteria were reported as a significant cause of infections in both community and nosocomial settings. Considered as one of the greatest threats to public health, the spread of bacteria drug resistance and the lack of effective alternative treatment options remains problematic. Herein,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/20/12457 |
| _version_ | 1797472761170362368 |
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| author | Azza Troudi Jean Michel Bolla Naouel Klibi Jean Michel Brunel |
| author_facet | Azza Troudi Jean Michel Bolla Naouel Klibi Jean Michel Brunel |
| author_sort | Azza Troudi |
| collection | DOAJ |
| description | Gram-negative bacteria were reported as a significant cause of infections in both community and nosocomial settings. Considered as one of the greatest threats to public health, the spread of bacteria drug resistance and the lack of effective alternative treatment options remains problematic. Herein, we report a promising strategy to combat Gram-negative resistant strains consisting of the combination of a macrolide antibiotic with a polyaminoisoprenyl adjuvant derivative leading to a significant decrease of antibiotic resistance. |
| first_indexed | 2024-03-09T20:05:49Z |
| format | Article |
| id | doaj.art-686ee72f7de2412fadb0f85dd0b3d9fd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:05:49Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-686ee72f7de2412fadb0f85dd0b3d9fd2023-11-24T00:31:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123201245710.3390/ijms232012457An Original and Efficient Antibiotic Adjuvant Strategy to Enhance the Activity of Macrolide Antibiotics against Gram-Negative Resistant StrainsAzza Troudi0Jean Michel Bolla1Naouel Klibi2Jean Michel Brunel3Aix Marseille Université, INSERM, SSA, MCT, 13385 Marseille, FranceAix Marseille Université, INSERM, SSA, MCT, 13385 Marseille, FranceLaboratory of Microorganisms and Active Biomolecules, Department of Biology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 1068, TunisiaAix Marseille Université, INSERM, SSA, MCT, 13385 Marseille, FranceGram-negative bacteria were reported as a significant cause of infections in both community and nosocomial settings. Considered as one of the greatest threats to public health, the spread of bacteria drug resistance and the lack of effective alternative treatment options remains problematic. Herein, we report a promising strategy to combat Gram-negative resistant strains consisting of the combination of a macrolide antibiotic with a polyaminoisoprenyl adjuvant derivative leading to a significant decrease of antibiotic resistance.https://www.mdpi.com/1422-0067/23/20/12457polyaminoisoprenyl derivativesantibiotic adjuvantspolyaminesGram-negative bacterial strainsmacrolide antibioticsouter membrane |
| spellingShingle | Azza Troudi Jean Michel Bolla Naouel Klibi Jean Michel Brunel An Original and Efficient Antibiotic Adjuvant Strategy to Enhance the Activity of Macrolide Antibiotics against Gram-Negative Resistant Strains International Journal of Molecular Sciences polyaminoisoprenyl derivatives antibiotic adjuvants polyamines Gram-negative bacterial strains macrolide antibiotics outer membrane |
| title | An Original and Efficient Antibiotic Adjuvant Strategy to Enhance the Activity of Macrolide Antibiotics against Gram-Negative Resistant Strains |
| title_full | An Original and Efficient Antibiotic Adjuvant Strategy to Enhance the Activity of Macrolide Antibiotics against Gram-Negative Resistant Strains |
| title_fullStr | An Original and Efficient Antibiotic Adjuvant Strategy to Enhance the Activity of Macrolide Antibiotics against Gram-Negative Resistant Strains |
| title_full_unstemmed | An Original and Efficient Antibiotic Adjuvant Strategy to Enhance the Activity of Macrolide Antibiotics against Gram-Negative Resistant Strains |
| title_short | An Original and Efficient Antibiotic Adjuvant Strategy to Enhance the Activity of Macrolide Antibiotics against Gram-Negative Resistant Strains |
| title_sort | original and efficient antibiotic adjuvant strategy to enhance the activity of macrolide antibiotics against gram negative resistant strains |
| topic | polyaminoisoprenyl derivatives antibiotic adjuvants polyamines Gram-negative bacterial strains macrolide antibiotics outer membrane |
| url | https://www.mdpi.com/1422-0067/23/20/12457 |
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