The role of autophagy in regulating metabolism in the tumor microenvironment
Autophagy, as a special programmed cell death, is a critical degradative process that eliminates intracellular abnormal proteins or damage organelles to balance cell energy and favor cell metabolism with autophagy-related (ATG) proteins. Autophagy activation is being increasingly recognized as an es...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-03-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304221001586 |
| _version_ | 1797699787721539584 |
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| author | Panpan Zhang Shanshan Cheng Xiaonan Sheng Huijuan Dai Kang He Yueyao Du |
| author_facet | Panpan Zhang Shanshan Cheng Xiaonan Sheng Huijuan Dai Kang He Yueyao Du |
| author_sort | Panpan Zhang |
| collection | DOAJ |
| description | Autophagy, as a special programmed cell death, is a critical degradative process that eliminates intracellular abnormal proteins or damage organelles to balance cell energy and favor cell metabolism with autophagy-related (ATG) proteins. Autophagy activation is being increasingly recognized as an essential hallmark in tumorigenesis through influencing the metabolism of stromal cells in the tumor microenvironment (TME) which comprises of tumor cells, cancer-associated fibroblasts (CAFs), cancer-associated endothelial cells (CAEs), immune cells and adipocytes. Tumor cells can reuse autophagy-involved recycling to maintain mitochondrial function and energy supply to meet the metabolic demand of their growth and proliferation. However, the mechanism through which autophagy can promote a crosstalk between tumor and stroma cells is not clear. Reprogramed metabolism is one of the main characteristics of TME leading to higher adaptability of tumor cells with diverse mechanisms. The activation of autophagy has expanded our understanding on the interaction between tumor metabolism and TME. The aim of this review is to report recent advances on the metabolic cross-talk between stromal cells and solid tumor cells induced by autophagy in TME and revealed potential therapeutic targets. |
| first_indexed | 2024-03-12T04:13:53Z |
| format | Article |
| id | doaj.art-68702860c248460caac8423e6a849d57 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T04:13:53Z |
| publishDate | 2023-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-68702860c248460caac8423e6a849d572023-09-03T10:49:15ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422023-03-01102447456The role of autophagy in regulating metabolism in the tumor microenvironmentPanpan Zhang0Shanshan Cheng1Xiaonan Sheng2Huijuan Dai3Kang He4Yueyao Du5Department of Gynecology and Obstetrics, Shanghai Key Laboratory of Gynecology Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, ChinaDepartment of Gynecology and Obstetrics, Shanghai Key Laboratory of Gynecology Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, ChinaDepartment of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 1630 Dongfang Road, Shanghai 200127, ChinaDepartment of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 1630 Dongfang Road, Shanghai 200127, ChinaDepartment of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; Corresponding author.Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, No. 1630 Dongfang Road, Shanghai 200127, China; Corresponding author.Autophagy, as a special programmed cell death, is a critical degradative process that eliminates intracellular abnormal proteins or damage organelles to balance cell energy and favor cell metabolism with autophagy-related (ATG) proteins. Autophagy activation is being increasingly recognized as an essential hallmark in tumorigenesis through influencing the metabolism of stromal cells in the tumor microenvironment (TME) which comprises of tumor cells, cancer-associated fibroblasts (CAFs), cancer-associated endothelial cells (CAEs), immune cells and adipocytes. Tumor cells can reuse autophagy-involved recycling to maintain mitochondrial function and energy supply to meet the metabolic demand of their growth and proliferation. However, the mechanism through which autophagy can promote a crosstalk between tumor and stroma cells is not clear. Reprogramed metabolism is one of the main characteristics of TME leading to higher adaptability of tumor cells with diverse mechanisms. The activation of autophagy has expanded our understanding on the interaction between tumor metabolism and TME. The aim of this review is to report recent advances on the metabolic cross-talk between stromal cells and solid tumor cells induced by autophagy in TME and revealed potential therapeutic targets.http://www.sciencedirect.com/science/article/pii/S2352304221001586AutophagyMetabolismTherapeutic targetsTumorTumor microenvironment |
| spellingShingle | Panpan Zhang Shanshan Cheng Xiaonan Sheng Huijuan Dai Kang He Yueyao Du The role of autophagy in regulating metabolism in the tumor microenvironment Genes and Diseases Autophagy Metabolism Therapeutic targets Tumor Tumor microenvironment |
| title | The role of autophagy in regulating metabolism in the tumor microenvironment |
| title_full | The role of autophagy in regulating metabolism in the tumor microenvironment |
| title_fullStr | The role of autophagy in regulating metabolism in the tumor microenvironment |
| title_full_unstemmed | The role of autophagy in regulating metabolism in the tumor microenvironment |
| title_short | The role of autophagy in regulating metabolism in the tumor microenvironment |
| title_sort | role of autophagy in regulating metabolism in the tumor microenvironment |
| topic | Autophagy Metabolism Therapeutic targets Tumor Tumor microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S2352304221001586 |
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