PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes

PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes

Astrocytes are a main target of JC polyomavirus (JCPyV) in the central nervous system (CNS), where the destruction of these cells, along with oligodendrocytes, leads to the fatal disease progressive multifocal leukoencephalopathy (PML). There is no cure currently available for PML, so it is essentia...

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Bibliographic Details
Main Authors: Michael P. Wilczek, Francesca J. Armstrong, Colleen L. Mayberry, Benjamin L. King, Melissa S. Maginnis
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
JC polyomavirus
PML
astrocytes
SVGA cells
primary cells
PI3K
Online Access:https://www.mdpi.com/2073-4409/10/11/3218

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