Palliative low dose fortnightly methotrexate in oral cancers: Experience at a rural cancer centre from India
Context: Palliative fortnightly chemotherapy in oral cancers. Aims: We present our experience with a regimen employing fortnightly (once in 2 weeks) injectable methotrexate (MTX) (40 mg/m 2 ) in a predominantly elderly cohort of patients with carcinoma of oral cavity and oropharynx. Settings and Des...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2014-01-01
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| Series: | South Asian Journal of Cancer |
| Subjects: | |
| Online Access: | http://journal.sajc.org/article.asp?issn=2278-330X;year=2014;volume=3;issue=3;spage=166;epage=170;aulast=Chakraborty |
| _version_ | 1818956242625757184 |
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| author | Santam Chakraborty M Geetha K M Sujith M S Biji B Sateeshan |
| author_facet | Santam Chakraborty M Geetha K M Sujith M S Biji B Sateeshan |
| author_sort | Santam Chakraborty |
| collection | DOAJ |
| description | Context: Palliative fortnightly chemotherapy in oral cancers. Aims: We present our experience with a regimen employing fortnightly (once in 2 weeks) injectable methotrexate (MTX) (40 mg/m 2 ) in a predominantly elderly cohort of patients with carcinoma of oral cavity and oropharynx. Settings and Design: Retrospective chart review conducted at a rural cancer center in India. Materials and Methods: All patients with oral cavity and oropharyngeal cancers started on treatment with fortnightly injectable MTX (40 mg/m 2 ) between 01/01/2011 and 31/12/2011. Statistical Analysis Used: The factors analyzed included the duration of disease control, pain control, overall survival and progression free survival which were evaluated using the Kaplan Meier method. Results: A total of 60 patients with a median age of 66.5 years were analyzed. Majority of the patients had poor nutritional status, performance status or co-morbidities. MTX was given for recurrent disease in 19 patients and after initial palliative radiotherapy in 41 patients. The median number of cycles delivered was nine. Grade 3/4 toxicities were seen in 2 patients only. Disease control rate at the end of treatment was seen in 33 (55%) patients. Median overall survival was 34 weeks (interquartile range: 17-50 weeks). Conclusions: The fortnightly regimen of MTX was well-tolerated and showed a good clinical activity in this elderly cohort of patients with advanced oral cavity and oropharyngeal cancers. |
| first_indexed | 2024-12-20T10:50:51Z |
| format | Article |
| id | doaj.art-687104898f804cebbabdd473aaf211ae |
| institution | Directory Open Access Journal |
| issn | 2278-330X 2278-4306 |
| language | English |
| last_indexed | 2024-12-20T10:50:51Z |
| publishDate | 2014-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | South Asian Journal of Cancer |
| spelling | doaj.art-687104898f804cebbabdd473aaf211ae2022-12-21T19:43:16ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2278-43062014-01-013316617010.4103/2278-330X.136798Palliative low dose fortnightly methotrexate in oral cancers: Experience at a rural cancer centre from IndiaSantam ChakrabortyM GeethaK M SujithM S BijiB SateeshanContext: Palliative fortnightly chemotherapy in oral cancers. Aims: We present our experience with a regimen employing fortnightly (once in 2 weeks) injectable methotrexate (MTX) (40 mg/m 2 ) in a predominantly elderly cohort of patients with carcinoma of oral cavity and oropharynx. Settings and Design: Retrospective chart review conducted at a rural cancer center in India. Materials and Methods: All patients with oral cavity and oropharyngeal cancers started on treatment with fortnightly injectable MTX (40 mg/m 2 ) between 01/01/2011 and 31/12/2011. Statistical Analysis Used: The factors analyzed included the duration of disease control, pain control, overall survival and progression free survival which were evaluated using the Kaplan Meier method. Results: A total of 60 patients with a median age of 66.5 years were analyzed. Majority of the patients had poor nutritional status, performance status or co-morbidities. MTX was given for recurrent disease in 19 patients and after initial palliative radiotherapy in 41 patients. The median number of cycles delivered was nine. Grade 3/4 toxicities were seen in 2 patients only. Disease control rate at the end of treatment was seen in 33 (55%) patients. Median overall survival was 34 weeks (interquartile range: 17-50 weeks). Conclusions: The fortnightly regimen of MTX was well-tolerated and showed a good clinical activity in this elderly cohort of patients with advanced oral cavity and oropharyngeal cancers.http://journal.sajc.org/article.asp?issn=2278-330X;year=2014;volume=3;issue=3;spage=166;epage=170;aulast=ChakrabortyMethotrexateoral cancerpalliative chemotherapysquamous cell cancers |
| spellingShingle | Santam Chakraborty M Geetha K M Sujith M S Biji B Sateeshan Palliative low dose fortnightly methotrexate in oral cancers: Experience at a rural cancer centre from India South Asian Journal of Cancer Methotrexate oral cancer palliative chemotherapy squamous cell cancers |
| title | Palliative low dose fortnightly methotrexate in oral cancers: Experience at a rural cancer centre from India |
| title_full | Palliative low dose fortnightly methotrexate in oral cancers: Experience at a rural cancer centre from India |
| title_fullStr | Palliative low dose fortnightly methotrexate in oral cancers: Experience at a rural cancer centre from India |
| title_full_unstemmed | Palliative low dose fortnightly methotrexate in oral cancers: Experience at a rural cancer centre from India |
| title_short | Palliative low dose fortnightly methotrexate in oral cancers: Experience at a rural cancer centre from India |
| title_sort | palliative low dose fortnightly methotrexate in oral cancers experience at a rural cancer centre from india |
| topic | Methotrexate oral cancer palliative chemotherapy squamous cell cancers |
| url | http://journal.sajc.org/article.asp?issn=2278-330X;year=2014;volume=3;issue=3;spage=166;epage=170;aulast=Chakraborty |
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