Climate drives the meningitis epidemics onset in west Africa.
BACKGROUND: Every year West African countries within the Sahelo-Sudanian band are afflicted with major meningococcal meningitis (MCM) disease outbreaks, which affect up to 200,000 people, mainly young children, in one of the world's poorest regions. The timing of the epidemic year, which starts...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2005-01-01
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| Series: | PLoS Medicine |
| Online Access: | http://europepmc.org/articles/PMC545199?pdf=render |
| _version_ | 1819042823042760704 |
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| author | Benjamin Sultan Karima Labadi Jean-François Guégan Serge Janicot |
| author_facet | Benjamin Sultan Karima Labadi Jean-François Guégan Serge Janicot |
| author_sort | Benjamin Sultan |
| collection | DOAJ |
| description | BACKGROUND: Every year West African countries within the Sahelo-Sudanian band are afflicted with major meningococcal meningitis (MCM) disease outbreaks, which affect up to 200,000 people, mainly young children, in one of the world's poorest regions. The timing of the epidemic year, which starts in February and ends in late May, and the spatial distribution of disease cases throughout the "Meningitis Belt" strongly indicate a close linkage between the life cycle of the causative agent of MCM and climate variability. However, mechanisms responsible for the observed patterns are still not clearly identified. METHODS AND FINDINGS: By comparing the information on cases and deaths of MCM from World Health Organization weekly reports with atmospheric datasets, we quantified the relationship between the seasonal occurrence of MCM in Mali, a West African country, and large-scale atmospheric circulation. Regional atmospheric indexes based on surface wind speed show a clear link between population dynamics of the disease and climate: the onset of epidemics and the winter maximum defined by the atmospheric index share the same mean week (sixth week of the year; standard deviation, 2 wk) and are highly correlated. CONCLUSIONS: This study is the first that provides a clear, quantitative demonstration of the connections that exist between MCM epidemics and regional climate variability in Africa. Moreover, this statistically robust explanation of the MCM dynamics enables the development of an Early Warning Index for meningitis epidemic onset in West Africa. The development of such an index will undoubtedly help nationwide and international public health institutions and policy makers to better control MCM disease within the so-called westward-eastward pan-African Meningitis Belt. |
| first_indexed | 2024-12-21T09:47:00Z |
| format | Article |
| id | doaj.art-687143a0b104400a900016db65f974b1 |
| institution | Directory Open Access Journal |
| issn | 1549-1277 1549-1676 |
| language | English |
| last_indexed | 2024-12-21T09:47:00Z |
| publishDate | 2005-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Medicine |
| spelling | doaj.art-687143a0b104400a900016db65f974b12022-12-21T19:08:18ZengPublic Library of Science (PLoS)PLoS Medicine1549-12771549-16762005-01-0121e610.1371/journal.pmed.0020006Climate drives the meningitis epidemics onset in west Africa.Benjamin SultanKarima LabadiJean-François GuéganSerge JanicotBACKGROUND: Every year West African countries within the Sahelo-Sudanian band are afflicted with major meningococcal meningitis (MCM) disease outbreaks, which affect up to 200,000 people, mainly young children, in one of the world's poorest regions. The timing of the epidemic year, which starts in February and ends in late May, and the spatial distribution of disease cases throughout the "Meningitis Belt" strongly indicate a close linkage between the life cycle of the causative agent of MCM and climate variability. However, mechanisms responsible for the observed patterns are still not clearly identified. METHODS AND FINDINGS: By comparing the information on cases and deaths of MCM from World Health Organization weekly reports with atmospheric datasets, we quantified the relationship between the seasonal occurrence of MCM in Mali, a West African country, and large-scale atmospheric circulation. Regional atmospheric indexes based on surface wind speed show a clear link between population dynamics of the disease and climate: the onset of epidemics and the winter maximum defined by the atmospheric index share the same mean week (sixth week of the year; standard deviation, 2 wk) and are highly correlated. CONCLUSIONS: This study is the first that provides a clear, quantitative demonstration of the connections that exist between MCM epidemics and regional climate variability in Africa. Moreover, this statistically robust explanation of the MCM dynamics enables the development of an Early Warning Index for meningitis epidemic onset in West Africa. The development of such an index will undoubtedly help nationwide and international public health institutions and policy makers to better control MCM disease within the so-called westward-eastward pan-African Meningitis Belt.http://europepmc.org/articles/PMC545199?pdf=render |
| spellingShingle | Benjamin Sultan Karima Labadi Jean-François Guégan Serge Janicot Climate drives the meningitis epidemics onset in west Africa. PLoS Medicine |
| title | Climate drives the meningitis epidemics onset in west Africa. |
| title_full | Climate drives the meningitis epidemics onset in west Africa. |
| title_fullStr | Climate drives the meningitis epidemics onset in west Africa. |
| title_full_unstemmed | Climate drives the meningitis epidemics onset in west Africa. |
| title_short | Climate drives the meningitis epidemics onset in west Africa. |
| title_sort | climate drives the meningitis epidemics onset in west africa |
| url | http://europepmc.org/articles/PMC545199?pdf=render |
| work_keys_str_mv | AT benjaminsultan climatedrivesthemeningitisepidemicsonsetinwestafrica AT karimalabadi climatedrivesthemeningitisepidemicsonsetinwestafrica AT jeanfrancoisguegan climatedrivesthemeningitisepidemicsonsetinwestafrica AT sergejanicot climatedrivesthemeningitisepidemicsonsetinwestafrica |