Thymic neoplasms patients complicated with bronchiectasis: Case series in a Chinese hospital and literature review
Background Bronchiectasis is a rare complication in patients with thymic neoplasm. The aim of this study was to investigate the clinical and radiological manifestations, laboratory tests, pathologic features, and outcome of treatment of bronchiectasis in patients with thymic neoplasm. Methods From J...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-04-01
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| Series: | Thoracic Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1759-7714.13000 |
| _version_ | 1797845472129318912 |
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| author | Yongjian Liu Yan Xu Xinlun Tian Hui Huang Xiaomeng Hou Minjiang Chen Wei Zhong Jing Zhao Jinming Gao Jinglan Wang Juhong Shi Mengzhao Wang |
| author_facet | Yongjian Liu Yan Xu Xinlun Tian Hui Huang Xiaomeng Hou Minjiang Chen Wei Zhong Jing Zhao Jinming Gao Jinglan Wang Juhong Shi Mengzhao Wang |
| author_sort | Yongjian Liu |
| collection | DOAJ |
| description | Background Bronchiectasis is a rare complication in patients with thymic neoplasm. The aim of this study was to investigate the clinical and radiological manifestations, laboratory tests, pathologic features, and outcome of treatment of bronchiectasis in patients with thymic neoplasm. Methods From January 2000 to January 2018, 20 patients with a diagnosis of thymic neoplasm and bronchiectasis were hospitalized at the Peking Union Medical College Hospital. Clinical data was retrospectively analyzed. Results The prevalence of bronchiectasis in thymic neoplasms in our cohort was 1.56% (20/1279). Eighteen patients were diagnosed with thymoma, while two patients were diagnosed with thymic carcinoid. The duration from diagnosis of thymic neoplasm to bronchiectasis varied. Distributions of bronchiectasis were bilateral in 17 patients and unilateral in three patients. Four patients were previously diagnosed with diffuse panbronchiolitis and another two were suspected with diffuse panbronchiolitis. Twelve patients had various parathymic syndromes, including Good syndrome, myasthenia gravis, and aplastic anemia. Thymectomy was performed in all of these patients. Macrolide antibiotics were administered to 10 patients, and the symptoms improved in 8. Conclusion Bronchiectasis is a complication in thymic neoplasms, although prevalence is low. There may be multifactorial etiologies for bronchiectasis in patients with thymic neoplasms. Comprehensive treatment should be carried out to ensure optimal outcomes. |
| first_indexed | 2024-04-09T17:39:34Z |
| format | Article |
| id | doaj.art-6872c62b32444c16902eae7d9c64d6ae |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-09T17:39:34Z |
| publishDate | 2019-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-6872c62b32444c16902eae7d9c64d6ae2023-04-17T06:34:28ZengWileyThoracic Cancer1759-77061759-77142019-04-0110479179810.1111/1759-7714.13000Thymic neoplasms patients complicated with bronchiectasis: Case series in a Chinese hospital and literature reviewYongjian Liu0Yan Xu1Xinlun Tian2Hui Huang3Xiaomeng Hou4Minjiang Chen5Wei Zhong6Jing Zhao7Jinming Gao8Jinglan Wang9Juhong Shi10Mengzhao Wang11Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing ChinaBackground Bronchiectasis is a rare complication in patients with thymic neoplasm. The aim of this study was to investigate the clinical and radiological manifestations, laboratory tests, pathologic features, and outcome of treatment of bronchiectasis in patients with thymic neoplasm. Methods From January 2000 to January 2018, 20 patients with a diagnosis of thymic neoplasm and bronchiectasis were hospitalized at the Peking Union Medical College Hospital. Clinical data was retrospectively analyzed. Results The prevalence of bronchiectasis in thymic neoplasms in our cohort was 1.56% (20/1279). Eighteen patients were diagnosed with thymoma, while two patients were diagnosed with thymic carcinoid. The duration from diagnosis of thymic neoplasm to bronchiectasis varied. Distributions of bronchiectasis were bilateral in 17 patients and unilateral in three patients. Four patients were previously diagnosed with diffuse panbronchiolitis and another two were suspected with diffuse panbronchiolitis. Twelve patients had various parathymic syndromes, including Good syndrome, myasthenia gravis, and aplastic anemia. Thymectomy was performed in all of these patients. Macrolide antibiotics were administered to 10 patients, and the symptoms improved in 8. Conclusion Bronchiectasis is a complication in thymic neoplasms, although prevalence is low. There may be multifactorial etiologies for bronchiectasis in patients with thymic neoplasms. Comprehensive treatment should be carried out to ensure optimal outcomes.https://doi.org/10.1111/1759-7714.13000Bronchiectasisdiffuse panbronchiolitisGood syndromethymic neoplasm |
| spellingShingle | Yongjian Liu Yan Xu Xinlun Tian Hui Huang Xiaomeng Hou Minjiang Chen Wei Zhong Jing Zhao Jinming Gao Jinglan Wang Juhong Shi Mengzhao Wang Thymic neoplasms patients complicated with bronchiectasis: Case series in a Chinese hospital and literature review Thoracic Cancer Bronchiectasis diffuse panbronchiolitis Good syndrome thymic neoplasm |
| title | Thymic neoplasms patients complicated with bronchiectasis: Case series in a Chinese hospital and literature review |
| title_full | Thymic neoplasms patients complicated with bronchiectasis: Case series in a Chinese hospital and literature review |
| title_fullStr | Thymic neoplasms patients complicated with bronchiectasis: Case series in a Chinese hospital and literature review |
| title_full_unstemmed | Thymic neoplasms patients complicated with bronchiectasis: Case series in a Chinese hospital and literature review |
| title_short | Thymic neoplasms patients complicated with bronchiectasis: Case series in a Chinese hospital and literature review |
| title_sort | thymic neoplasms patients complicated with bronchiectasis case series in a chinese hospital and literature review |
| topic | Bronchiectasis diffuse panbronchiolitis Good syndrome thymic neoplasm |
| url | https://doi.org/10.1111/1759-7714.13000 |
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