Gout is not associated with the risk of fracture: a meta-analysis
Abstract Background Numerous quantitatively based studies measuring the association between gout and the risk of fractures remain inconclusive. In order to determine whether gout could increase the risk of fractures, a meta-analysis was performed systematically. Methods Electronic databases, MEDLINE...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-019-1317-4 |
| _version_ | 1828150278152519680 |
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| author | Fanxiao Liu Jinlei Dong Dongsheng Zhou Qinglin Kang Fei Xiong |
| author_facet | Fanxiao Liu Jinlei Dong Dongsheng Zhou Qinglin Kang Fei Xiong |
| author_sort | Fanxiao Liu |
| collection | DOAJ |
| description | Abstract Background Numerous quantitatively based studies measuring the association between gout and the risk of fractures remain inconclusive. In order to determine whether gout could increase the risk of fractures, a meta-analysis was performed systematically. Methods Electronic databases, MEDLINE/PubMed, Embase, and Cochrane Library were systematically searched to identify studies evaluating the association of gout and the risk of fractures. No restrictions on language, publication date, or journal of publication were imposed. Meta-analysis was performed to pool the outcome estimates of interest such as fracture incidence, fracture risk, and fracture risk in different sites and at different time points in the follow-up period. Results Screening determined that seven studies involving a total of 684,964 participants (151,002 in the gout group and 533,962 in the control group) were deemed viable for inclusion in the meta-analysis. The results of the analysis showed that gout would not significantly have a relatively higher risk of any fracture (RR = 1.11, 95% CI 0.98–1.26). Subgroup analysis showed consistent results for sexuality (female: RR = 1.13, 95% CI 0.93–1.37; male: RR = 0.99, 95% CI 0.91–1.07) and several occurring sites (humerus, wrist, vertebra, hip, upper limbs, and lower limbs). Additionally, the results demonstrated that urate-lowering drugs prescribed early during disease had neither adverse nor beneficial effect on the long-term risk of fractures (RR = 0.89, 95% CI 0.76–1.05). Conclusions This meta-analysis confirmed that gout was not associated with an increased risk of fractures. Urate-lowering drugs prescribed early during the course of disease had neither adverse nor beneficial effect on the long-term risk of fractures. |
| first_indexed | 2024-04-11T21:42:03Z |
| format | Article |
| id | doaj.art-6873a2a973bd4de7b4efb70360f630b6 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T21:42:03Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-6873a2a973bd4de7b4efb70360f630b62022-12-22T04:01:34ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2019-08-0114111210.1186/s13018-019-1317-4Gout is not associated with the risk of fracture: a meta-analysisFanxiao Liu0Jinlei Dong1Dongsheng Zhou2Qinglin Kang3Fei Xiong4Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong UniversityDepartment of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong UniversityDepartment of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong UniversityDepartment of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalDepartment of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalAbstract Background Numerous quantitatively based studies measuring the association between gout and the risk of fractures remain inconclusive. In order to determine whether gout could increase the risk of fractures, a meta-analysis was performed systematically. Methods Electronic databases, MEDLINE/PubMed, Embase, and Cochrane Library were systematically searched to identify studies evaluating the association of gout and the risk of fractures. No restrictions on language, publication date, or journal of publication were imposed. Meta-analysis was performed to pool the outcome estimates of interest such as fracture incidence, fracture risk, and fracture risk in different sites and at different time points in the follow-up period. Results Screening determined that seven studies involving a total of 684,964 participants (151,002 in the gout group and 533,962 in the control group) were deemed viable for inclusion in the meta-analysis. The results of the analysis showed that gout would not significantly have a relatively higher risk of any fracture (RR = 1.11, 95% CI 0.98–1.26). Subgroup analysis showed consistent results for sexuality (female: RR = 1.13, 95% CI 0.93–1.37; male: RR = 0.99, 95% CI 0.91–1.07) and several occurring sites (humerus, wrist, vertebra, hip, upper limbs, and lower limbs). Additionally, the results demonstrated that urate-lowering drugs prescribed early during disease had neither adverse nor beneficial effect on the long-term risk of fractures (RR = 0.89, 95% CI 0.76–1.05). Conclusions This meta-analysis confirmed that gout was not associated with an increased risk of fractures. Urate-lowering drugs prescribed early during the course of disease had neither adverse nor beneficial effect on the long-term risk of fractures.http://link.springer.com/article/10.1186/s13018-019-1317-4GoutMeta-analysisFracture riskUrate-lowering drugs |
| spellingShingle | Fanxiao Liu Jinlei Dong Dongsheng Zhou Qinglin Kang Fei Xiong Gout is not associated with the risk of fracture: a meta-analysis Journal of Orthopaedic Surgery and Research Gout Meta-analysis Fracture risk Urate-lowering drugs |
| title | Gout is not associated with the risk of fracture: a meta-analysis |
| title_full | Gout is not associated with the risk of fracture: a meta-analysis |
| title_fullStr | Gout is not associated with the risk of fracture: a meta-analysis |
| title_full_unstemmed | Gout is not associated with the risk of fracture: a meta-analysis |
| title_short | Gout is not associated with the risk of fracture: a meta-analysis |
| title_sort | gout is not associated with the risk of fracture a meta analysis |
| topic | Gout Meta-analysis Fracture risk Urate-lowering drugs |
| url | http://link.springer.com/article/10.1186/s13018-019-1317-4 |
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