MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics
Actin and its dynamic structural remodelings are involved in multiple cellular functions, including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle contraction. Many actin-binding proteins regulate the cytoskeleton to facilitate these functions. Recently, actin’s...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1124202/full |
| _version_ | 1797904012846039040 |
|---|---|
| author | Sudeepa Rajan Jonathan R. Terman Emil Reisler Emil Reisler |
| author_facet | Sudeepa Rajan Jonathan R. Terman Emil Reisler Emil Reisler |
| author_sort | Sudeepa Rajan |
| collection | DOAJ |
| description | Actin and its dynamic structural remodelings are involved in multiple cellular functions, including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle contraction. Many actin-binding proteins regulate the cytoskeleton to facilitate these functions. Recently, actin’s post-translational modifications (PTMs) and their importance to actin functions have gained increasing recognition. The MICAL family of proteins has emerged as important actin regulatory oxidation-reduction (Redox) enzymes, influencing actin’s properties both in vitro and in vivo. MICALs specifically bind to actin filaments and selectively oxidize actin’s methionine residues 44 and 47, which perturbs filaments’ structure and leads to their disassembly. This review provides an overview of the MICALs and the impact of MICAL-mediated oxidation on actin’s properties, including its assembly and disassembly, effects on other actin-binding proteins, and on cells and tissue systems. |
| first_indexed | 2024-04-10T09:42:03Z |
| format | Article |
| id | doaj.art-6873f7124ba74852a37294e33c717c8c |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-10T09:42:03Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-6873f7124ba74852a37294e33c717c8c2023-02-17T08:37:42ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-02-011110.3389/fcell.2023.11242021124202MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamicsSudeepa Rajan0Jonathan R. Terman1Emil Reisler2Emil Reisler3Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, United StatesDepartments of Neuroscience and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, United StatesDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, United StatesMolecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, United StatesActin and its dynamic structural remodelings are involved in multiple cellular functions, including maintaining cell shape and integrity, cytokinesis, motility, navigation, and muscle contraction. Many actin-binding proteins regulate the cytoskeleton to facilitate these functions. Recently, actin’s post-translational modifications (PTMs) and their importance to actin functions have gained increasing recognition. The MICAL family of proteins has emerged as important actin regulatory oxidation-reduction (Redox) enzymes, influencing actin’s properties both in vitro and in vivo. MICALs specifically bind to actin filaments and selectively oxidize actin’s methionine residues 44 and 47, which perturbs filaments’ structure and leads to their disassembly. This review provides an overview of the MICALs and the impact of MICAL-mediated oxidation on actin’s properties, including its assembly and disassembly, effects on other actin-binding proteins, and on cells and tissue systems.https://www.frontiersin.org/articles/10.3389/fcell.2023.1124202/fullMICAL1MICAL2MICAL3MsrBSelRsemaphorin |
| spellingShingle | Sudeepa Rajan Jonathan R. Terman Emil Reisler Emil Reisler MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics Frontiers in Cell and Developmental Biology MICAL1 MICAL2 MICAL3 MsrB SelR semaphorin |
| title | MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics |
| title_full | MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics |
| title_fullStr | MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics |
| title_full_unstemmed | MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics |
| title_short | MICAL-mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics |
| title_sort | mical mediated oxidation of actin and its effects on cytoskeletal and cellular dynamics |
| topic | MICAL1 MICAL2 MICAL3 MsrB SelR semaphorin |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1124202/full |
| work_keys_str_mv | AT sudeeparajan micalmediatedoxidationofactinanditseffectsoncytoskeletalandcellulardynamics AT jonathanrterman micalmediatedoxidationofactinanditseffectsoncytoskeletalandcellulardynamics AT emilreisler micalmediatedoxidationofactinanditseffectsoncytoskeletalandcellulardynamics AT emilreisler micalmediatedoxidationofactinanditseffectsoncytoskeletalandcellulardynamics |