Bisphenol-S influence on oxidative stress and endocrine biomarkers of reproductive system: A systematic review and meta-analysis
Background: Bisphenol-S (BPS), as a new human public health concern, was introduced to the plastic industry by BPA-free labeled products following the restrictions of Bisphenol-A (BPA) as a safe alternative. However, recent research has revealed a controversial issue. In this regard, the present stu...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | International Journal of Preventive Medicine |
| Subjects: | |
| Online Access: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2023;volume=14;issue=1;spage=37;epage=37;aulast=Abouhamzeh |
| _version_ | 1797824173866745856 |
|---|---|
| author | Beheshteh Abouhamzeh Zohreh Zare Moslem Mohammadi Mahmood Moosazadeh Alireza Nourian |
| author_facet | Beheshteh Abouhamzeh Zohreh Zare Moslem Mohammadi Mahmood Moosazadeh Alireza Nourian |
| author_sort | Beheshteh Abouhamzeh |
| collection | DOAJ |
| description | Background: Bisphenol-S (BPS), as a new human public health concern, was introduced to the plastic industry by BPA-free labeled products following the restrictions of Bisphenol-A (BPA) as a safe alternative. However, recent research has revealed a controversial issue. In this regard, the present study aimed to review the relationship between BPS exposure and reproductive system dis/malfunction. Methods: PubMed and other databases were searched up to January 2021. The standard mean difference (SMD) with a 95% confidence interval (CI) was calculated for the main parameters using the random-effects model. Finally, 12 studies with 420 subjects were included in this research. Forest plot, meta-regression, and non-linear dose-response effect were calculated for each parameter by random-effects model. Results: Based on the results of in vitro assessment, a significant increase was found in the oxidative stress parameters, including superoxide dismutase (SMD: 0.63, 95% CI: 0.321, 0.939), thiobarbituric acid reactive substances (SMD: 0.760, 95% CI: 0.423, 1.096), and reactive oxygen species (SMD: 0.484, 95% CI: 0.132, 0.835). In addition, the hormonal assessment revealed a significant decrease in male testosterone concertation (SMD: -0.476, 95% CI: -0.881, -0.071). Moreover, in vivo examination revealed a significant decrease in hormonal parameters, such as female testosterone (SMD: -0.808, 95% CI: -1.149, -0.467), female estrogen (SMD: -2.608, 95% CI: -4.588, -0.628), female luteinizing hormone (SMD: -0.386, 95% CI: -0.682, -0.089), and female follicle-stimulating hormone (FSH) (SMD: -0.418, 95% CI: -0.716, -0.119). Besides, linear and non-linear correlations were detected in the main parameters. Conclusion: In conclusion, based on the current meta-analysis, BPS was suggested to be toxic for the reproductive system, similar to the other bisphenols. Moreover, a possible correlation was indicated between oxidative and hormonal status disruption induced by BPS in male and female reproductive systems dis/malfunction. |
| first_indexed | 2024-03-13T10:35:01Z |
| format | Article |
| id | doaj.art-6874b04e31e941919de955701df281c2 |
| institution | Directory Open Access Journal |
| issn | 2008-7802 2008-8213 |
| language | English |
| last_indexed | 2024-03-13T10:35:01Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Preventive Medicine |
| spelling | doaj.art-6874b04e31e941919de955701df281c22023-05-18T06:20:57ZengWolters Kluwer Medknow PublicationsInternational Journal of Preventive Medicine2008-78022008-82132023-01-01141373710.4103/ijpvm.ijpvm_271_21Bisphenol-S influence on oxidative stress and endocrine biomarkers of reproductive system: A systematic review and meta-analysisBeheshteh AbouhamzehZohreh ZareMoslem MohammadiMahmood MoosazadehAlireza NourianBackground: Bisphenol-S (BPS), as a new human public health concern, was introduced to the plastic industry by BPA-free labeled products following the restrictions of Bisphenol-A (BPA) as a safe alternative. However, recent research has revealed a controversial issue. In this regard, the present study aimed to review the relationship between BPS exposure and reproductive system dis/malfunction. Methods: PubMed and other databases were searched up to January 2021. The standard mean difference (SMD) with a 95% confidence interval (CI) was calculated for the main parameters using the random-effects model. Finally, 12 studies with 420 subjects were included in this research. Forest plot, meta-regression, and non-linear dose-response effect were calculated for each parameter by random-effects model. Results: Based on the results of in vitro assessment, a significant increase was found in the oxidative stress parameters, including superoxide dismutase (SMD: 0.63, 95% CI: 0.321, 0.939), thiobarbituric acid reactive substances (SMD: 0.760, 95% CI: 0.423, 1.096), and reactive oxygen species (SMD: 0.484, 95% CI: 0.132, 0.835). In addition, the hormonal assessment revealed a significant decrease in male testosterone concertation (SMD: -0.476, 95% CI: -0.881, -0.071). Moreover, in vivo examination revealed a significant decrease in hormonal parameters, such as female testosterone (SMD: -0.808, 95% CI: -1.149, -0.467), female estrogen (SMD: -2.608, 95% CI: -4.588, -0.628), female luteinizing hormone (SMD: -0.386, 95% CI: -0.682, -0.089), and female follicle-stimulating hormone (FSH) (SMD: -0.418, 95% CI: -0.716, -0.119). Besides, linear and non-linear correlations were detected in the main parameters. Conclusion: In conclusion, based on the current meta-analysis, BPS was suggested to be toxic for the reproductive system, similar to the other bisphenols. Moreover, a possible correlation was indicated between oxidative and hormonal status disruption induced by BPS in male and female reproductive systems dis/malfunction.http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2023;volume=14;issue=1;spage=37;epage=37;aulast=Abouhamzehbisphenol sglandmeta-analysisoxidative stressreproductive system |
| spellingShingle | Beheshteh Abouhamzeh Zohreh Zare Moslem Mohammadi Mahmood Moosazadeh Alireza Nourian Bisphenol-S influence on oxidative stress and endocrine biomarkers of reproductive system: A systematic review and meta-analysis International Journal of Preventive Medicine bisphenol s gland meta-analysis oxidative stress reproductive system |
| title | Bisphenol-S influence on oxidative stress and endocrine biomarkers of reproductive system: A systematic review and meta-analysis |
| title_full | Bisphenol-S influence on oxidative stress and endocrine biomarkers of reproductive system: A systematic review and meta-analysis |
| title_fullStr | Bisphenol-S influence on oxidative stress and endocrine biomarkers of reproductive system: A systematic review and meta-analysis |
| title_full_unstemmed | Bisphenol-S influence on oxidative stress and endocrine biomarkers of reproductive system: A systematic review and meta-analysis |
| title_short | Bisphenol-S influence on oxidative stress and endocrine biomarkers of reproductive system: A systematic review and meta-analysis |
| title_sort | bisphenol s influence on oxidative stress and endocrine biomarkers of reproductive system a systematic review and meta analysis |
| topic | bisphenol s gland meta-analysis oxidative stress reproductive system |
| url | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2023;volume=14;issue=1;spage=37;epage=37;aulast=Abouhamzeh |
| work_keys_str_mv | AT beheshtehabouhamzeh bisphenolsinfluenceonoxidativestressandendocrinebiomarkersofreproductivesystemasystematicreviewandmetaanalysis AT zohrehzare bisphenolsinfluenceonoxidativestressandendocrinebiomarkersofreproductivesystemasystematicreviewandmetaanalysis AT moslemmohammadi bisphenolsinfluenceonoxidativestressandendocrinebiomarkersofreproductivesystemasystematicreviewandmetaanalysis AT mahmoodmoosazadeh bisphenolsinfluenceonoxidativestressandendocrinebiomarkersofreproductivesystemasystematicreviewandmetaanalysis AT alirezanourian bisphenolsinfluenceonoxidativestressandendocrinebiomarkersofreproductivesystemasystematicreviewandmetaanalysis |