Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer
Abstract Predicting survival accurately in patients with advanced cancer is important in guiding interventions and planning future care. Objective tools are therefore needed. Blood biomarkers are appealing due to their rapid measurement and objective nature. Thrombosis is a common complication in ca...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-84476-3 |
| _version_ | 1818345915567570944 |
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| author | Axel Rosell Katherina Aguilera Yohei Hisada Clare Schmedes Nigel Mackman Håkan Wallén Staffan Lundström Charlotte Thålin |
| author_facet | Axel Rosell Katherina Aguilera Yohei Hisada Clare Schmedes Nigel Mackman Håkan Wallén Staffan Lundström Charlotte Thålin |
| author_sort | Axel Rosell |
| collection | DOAJ |
| description | Abstract Predicting survival accurately in patients with advanced cancer is important in guiding interventions and planning future care. Objective tools are therefore needed. Blood biomarkers are appealing due to their rapid measurement and objective nature. Thrombosis is a common complication in cancer. Recent data indicate that tumor-induced neutrophil extracellular traps (NETs) are pro-thrombotic. We therefore performed a comprehensive investigation of circulating markers of neutrophil activation, NET formation, coagulation and fibrinolysis in 106 patients with terminal cancer. We found that neutrophil activation and NET markers were prognostic in terminal cancer patients. Interestingly, markers of coagulation and fibrinolysis did not have a prognostic value in this patient group, and there were weak or no correlations between these markers and markers of neutrophil activation and NETs. This suggest that NETs are linked to a poor prognosis through pathways independent of coagulation. Additional studies are needed to determine the utility of circulating neutrophil activation and NET markers, alone or in concert with established clinical parameters, as objective and reliable prognostic tools in advanced cancer. |
| first_indexed | 2024-12-13T17:09:58Z |
| format | Article |
| id | doaj.art-6878c987d3634635982d478f171288b0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T17:09:58Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6878c987d3634635982d478f171288b02022-12-21T23:37:34ZengNature PortfolioScientific Reports2045-23222021-03-011111910.1038/s41598-021-84476-3Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancerAxel Rosell0Katherina Aguilera1Yohei Hisada2Clare Schmedes3Nigel Mackman4Håkan Wallén5Staffan Lundström6Charlotte Thålin7Department of Clinical Sciences, Danderyd Hospital, Division of Internal Medicine, Karolinska InstitutetDepartment of Clinical Sciences, Danderyd Hospital, Division of Internal Medicine, Karolinska InstitutetUNC Blood Research Center, Division of Hematology, Department of Medicine, University of North Carolina at Chapel HillUNC Blood Research Center, Division of Hematology, Department of Medicine, University of North Carolina at Chapel HillUNC Blood Research Center, Division of Hematology, Department of Medicine, University of North Carolina at Chapel HillDepartment of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Karolinska InstitutetPalliative Care Services and R&D-Unit, Stockholms Sjukhem FoundationDepartment of Clinical Sciences, Danderyd Hospital, Division of Internal Medicine, Karolinska InstitutetAbstract Predicting survival accurately in patients with advanced cancer is important in guiding interventions and planning future care. Objective tools are therefore needed. Blood biomarkers are appealing due to their rapid measurement and objective nature. Thrombosis is a common complication in cancer. Recent data indicate that tumor-induced neutrophil extracellular traps (NETs) are pro-thrombotic. We therefore performed a comprehensive investigation of circulating markers of neutrophil activation, NET formation, coagulation and fibrinolysis in 106 patients with terminal cancer. We found that neutrophil activation and NET markers were prognostic in terminal cancer patients. Interestingly, markers of coagulation and fibrinolysis did not have a prognostic value in this patient group, and there were weak or no correlations between these markers and markers of neutrophil activation and NETs. This suggest that NETs are linked to a poor prognosis through pathways independent of coagulation. Additional studies are needed to determine the utility of circulating neutrophil activation and NET markers, alone or in concert with established clinical parameters, as objective and reliable prognostic tools in advanced cancer.https://doi.org/10.1038/s41598-021-84476-3 |
| spellingShingle | Axel Rosell Katherina Aguilera Yohei Hisada Clare Schmedes Nigel Mackman Håkan Wallén Staffan Lundström Charlotte Thålin Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer Scientific Reports |
| title | Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer |
| title_full | Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer |
| title_fullStr | Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer |
| title_full_unstemmed | Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer |
| title_short | Prognostic value of circulating markers of neutrophil activation, neutrophil extracellular traps, coagulation and fibrinolysis in patients with terminal cancer |
| title_sort | prognostic value of circulating markers of neutrophil activation neutrophil extracellular traps coagulation and fibrinolysis in patients with terminal cancer |
| url | https://doi.org/10.1038/s41598-021-84476-3 |
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