Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity
Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superpa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | Antibiotics |
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| Online Access: | http://www.mdpi.com/2079-6382/7/2/46 |
| _version_ | 1819120385042415616 |
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| author | Laís Salomão Arias Juliano Pelim Pessan Ana Paula Miranda Vieira Taynara Maria Toito de Lima Alberto Carlos Botazzo Delbem Douglas Roberto Monteiro |
| author_facet | Laís Salomão Arias Juliano Pelim Pessan Ana Paula Miranda Vieira Taynara Maria Toito de Lima Alberto Carlos Botazzo Delbem Douglas Roberto Monteiro |
| author_sort | Laís Salomão Arias |
| collection | DOAJ |
| description | Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. Ongoing research efforts focus on reducing drug concentration, toxicity, and other side effects, while increasing efficacy of IONPs-based treatments. This review highlights the methods of synthesis and presents the most recent reports in the literature regarding advances in drug delivery using IONPs-based systems, as well as their antimicrobial activity against different microorganisms. Furthermore, the toxicity of IONPs alone and constituting nanosystems is also addressed. |
| first_indexed | 2024-12-22T06:19:49Z |
| format | Article |
| id | doaj.art-687cb90f219d4bfeab2569479aae7814 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-22T06:19:49Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-687cb90f219d4bfeab2569479aae78142022-12-21T18:36:00ZengMDPI AGAntibiotics2079-63822018-06-01724610.3390/antibiotics7020046antibiotics7020046Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and ToxicityLaís Salomão Arias0Juliano Pelim Pessan1Ana Paula Miranda Vieira2Taynara Maria Toito de Lima3Alberto Carlos Botazzo Delbem4Douglas Roberto Monteiro5Department of Pediatric Dentistry and Public Health, School of Dentistry, Araçatuba, São Paulo State University (Unesp), 16015-050 Araçatuba/São Paulo, BrazilDepartment of Pediatric Dentistry and Public Health, School of Dentistry, Araçatuba, São Paulo State University (Unesp), 16015-050 Araçatuba/São Paulo, BrazilDepartment of Pediatric Dentistry and Public Health, School of Dentistry, Araçatuba, São Paulo State University (Unesp), 16015-050 Araçatuba/São Paulo, BrazilGraduate Program in Dentistry (GPD-Master’s Degree), University of Western São Paulo (UNOESTE), 19050-920 Presidente Prudente/São Paulo, BrazilDepartment of Pediatric Dentistry and Public Health, School of Dentistry, Araçatuba, São Paulo State University (Unesp), 16015-050 Araçatuba/São Paulo, BrazilGraduate Program in Dentistry (GPD-Master’s Degree), University of Western São Paulo (UNOESTE), 19050-920 Presidente Prudente/São Paulo, BrazilMedical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. Ongoing research efforts focus on reducing drug concentration, toxicity, and other side effects, while increasing efficacy of IONPs-based treatments. This review highlights the methods of synthesis and presents the most recent reports in the literature regarding advances in drug delivery using IONPs-based systems, as well as their antimicrobial activity against different microorganisms. Furthermore, the toxicity of IONPs alone and constituting nanosystems is also addressed.http://www.mdpi.com/2079-6382/7/2/46biotechnologydrug deliveryiron oxide nanoparticlesmagnetic nanoparticles |
| spellingShingle | Laís Salomão Arias Juliano Pelim Pessan Ana Paula Miranda Vieira Taynara Maria Toito de Lima Alberto Carlos Botazzo Delbem Douglas Roberto Monteiro Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity Antibiotics biotechnology drug delivery iron oxide nanoparticles magnetic nanoparticles |
| title | Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity |
| title_full | Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity |
| title_fullStr | Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity |
| title_full_unstemmed | Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity |
| title_short | Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity |
| title_sort | iron oxide nanoparticles for biomedical applications a perspective on synthesis drugs antimicrobial activity and toxicity |
| topic | biotechnology drug delivery iron oxide nanoparticles magnetic nanoparticles |
| url | http://www.mdpi.com/2079-6382/7/2/46 |
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