Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens
This study aimed to assess the possible feeding behavior alterations by central interactions of cholecystokinin (CCK) and glutamatergic systems in neonatal chickens. In experiment 1, chickens received intracerebroventricular (ICV) administration of saline and CCK (CCK4; 0.25, 0.5, and 1 nmol). In ex...
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| Language: | English |
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Razi Vaccine and Serum Research Institute
2022-04-01
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| Series: | Archives of Razi Institute |
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| Online Access: | https://archrazi.areeo.ac.ir/article_125920_548fa3ecd78423e10fd6b9573c9a2e8e.pdf |
| _version_ | 1817976396211814400 |
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| author | M Jelokhani B Vazir M Zendehdel A Jahandideh |
| author_facet | M Jelokhani B Vazir M Zendehdel A Jahandideh |
| author_sort | M Jelokhani |
| collection | DOAJ |
| description | This study aimed to assess the possible feeding behavior alterations by central interactions of cholecystokinin (CCK) and glutamatergic systems in neonatal chickens. In experiment 1, chickens received intracerebroventricular (ICV) administration of saline and CCK (CCK4; 0.25, 0.5, and 1 nmol). In experiment 2, birds were ICV injected with saline, CCK8s (0.25, 0.5, and 1 nmol). In experiment 3, chickens received the ICV injection of saline, CCK8s (1 nmol), MK-801 (15 nmol), and co-injection of the CCk8s+MK-801. Experiments 4-7 were performed similar to experiment 3, except for chickens that were injected with CNQX (390 nmol), AIDA (2 nmol), LY341495 (150 nmol), and UBP1112 (2 nmol) instead of MK-801. Subsequently, the total amount of the consumed food was determined. According to the results, the ICV administration of CCK4 (0.25, 0.5, and 1 nmol) could not affect the food intake in chickens (P>0.05). The ICV injection of the CCK8s (0.25, 0.5, and 1 nmol) led to a dose-dependent hypophagia (P<0.05). Moreover, hypophagia induced by CCK8s decreased by the co-injection of the CCK8s+MK-801 (P<0.05). These results showed that the hypophagic effects of the CCK on food intake can be mediated by NMDA glutamate receptors in layer-type chickens. |
| first_indexed | 2024-04-13T22:02:57Z |
| format | Article |
| id | doaj.art-687d20f4521c4b0bb9caabb55185eed4 |
| institution | Directory Open Access Journal |
| issn | 0365-3439 2008-9872 |
| language | English |
| last_indexed | 2024-04-13T22:02:57Z |
| publishDate | 2022-04-01 |
| publisher | Razi Vaccine and Serum Research Institute |
| record_format | Article |
| series | Archives of Razi Institute |
| spelling | doaj.art-687d20f4521c4b0bb9caabb55185eed42022-12-22T02:28:02ZengRazi Vaccine and Serum Research InstituteArchives of Razi Institute0365-34392008-98722022-04-0177268168810.22092/ari.2022.357300.2015125920Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal ChickensM Jelokhani0B Vazir1M Zendehdel2A Jahandideh3Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, IranThis study aimed to assess the possible feeding behavior alterations by central interactions of cholecystokinin (CCK) and glutamatergic systems in neonatal chickens. In experiment 1, chickens received intracerebroventricular (ICV) administration of saline and CCK (CCK4; 0.25, 0.5, and 1 nmol). In experiment 2, birds were ICV injected with saline, CCK8s (0.25, 0.5, and 1 nmol). In experiment 3, chickens received the ICV injection of saline, CCK8s (1 nmol), MK-801 (15 nmol), and co-injection of the CCk8s+MK-801. Experiments 4-7 were performed similar to experiment 3, except for chickens that were injected with CNQX (390 nmol), AIDA (2 nmol), LY341495 (150 nmol), and UBP1112 (2 nmol) instead of MK-801. Subsequently, the total amount of the consumed food was determined. According to the results, the ICV administration of CCK4 (0.25, 0.5, and 1 nmol) could not affect the food intake in chickens (P>0.05). The ICV injection of the CCK8s (0.25, 0.5, and 1 nmol) led to a dose-dependent hypophagia (P<0.05). Moreover, hypophagia induced by CCK8s decreased by the co-injection of the CCK8s+MK-801 (P<0.05). These results showed that the hypophagic effects of the CCK on food intake can be mediated by NMDA glutamate receptors in layer-type chickens.https://archrazi.areeo.ac.ir/article_125920_548fa3ecd78423e10fd6b9573c9a2e8e.pdfchickenscholecystokininfood intakeglutamatergic |
| spellingShingle | M Jelokhani B Vazir M Zendehdel A Jahandideh Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens Archives of Razi Institute chickens cholecystokinin food intake glutamatergic |
| title | Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens |
| title_full | Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens |
| title_fullStr | Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens |
| title_full_unstemmed | Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens |
| title_short | Interactions of Cholecystokinin and Glutamatergic Systems in Feeding Behavior of Neonatal Chickens |
| title_sort | interactions of cholecystokinin and glutamatergic systems in feeding behavior of neonatal chickens |
| topic | chickens cholecystokinin food intake glutamatergic |
| url | https://archrazi.areeo.ac.ir/article_125920_548fa3ecd78423e10fd6b9573c9a2e8e.pdf |
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