Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls
Abstract Anorexia nervosa (AN) and atypical AN (AtypAN) are complex neurobiological illnesses that typically onset in adolescence with an often treatment-refractory and chronic illness trajectory. Aberrant eating behaviors in this population have been linked to abnormalities in food reward and cogni...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-06-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-023-02494-3 |
| _version_ | 1827916711401095168 |
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| author | Kamryn T. Eddy Franziska Plessow Lauren Breithaupt Kendra R. Becker Meghan Slattery Christopher J. Mancuso Alyssa M. Izquierdo Avery L. Van De Water Danielle L. Kahn Melissa J. Dreier Seda Ebrahimi Thilo Deckersbach Jennifer J. Thomas Laura M. Holsen Madhusmita Misra Elizabeth A. Lawson |
| author_facet | Kamryn T. Eddy Franziska Plessow Lauren Breithaupt Kendra R. Becker Meghan Slattery Christopher J. Mancuso Alyssa M. Izquierdo Avery L. Van De Water Danielle L. Kahn Melissa J. Dreier Seda Ebrahimi Thilo Deckersbach Jennifer J. Thomas Laura M. Holsen Madhusmita Misra Elizabeth A. Lawson |
| author_sort | Kamryn T. Eddy |
| collection | DOAJ |
| description | Abstract Anorexia nervosa (AN) and atypical AN (AtypAN) are complex neurobiological illnesses that typically onset in adolescence with an often treatment-refractory and chronic illness trajectory. Aberrant eating behaviors in this population have been linked to abnormalities in food reward and cognitive control, but prior studies have not examined respective contributions of clinical characteristics and metabolic state. Research is needed to identify specific disruptions and inform novel intervention targets to improve outcomes. Fifty-nine females with AN (n = 34) or AtypAN (n = 25), ages 10–22 years, all ≤90% expected body weight, and 34 age-matched healthy controls (HC) completed a well-established neuroimaging food cue paradigm fasting and after a standardized meal, and we used ANCOVA models to investigate main and interaction effects of Group and Appetitive State on blood oxygenation level-dependent (BOLD) activation for the contrast of exposure to high-calorie food images minus objects. We found main effects of Group with greater BOLD activation in the dorsal anterior cingulate cortex (dACC), dorsolateral prefrontal cortex (DLPFC), hippocampus, caudate, and putamen for AN/AtypAN versus HC groups, and in the three-group model including AN, AtypAN, and HC (sub-)groups, where differences were primarily driven by greater activation in the AtypAN subgroup versus HC group. We found a main effect of Appetitive State with increased premeal BOLD activation in the hypothalamus, amygdala, nucleus accumbens, and caudate for models that included AN/AtypAN and HC groups, and in BOLD activation in the nucleus accumbens for the model that included AN, AtypAN, and HC (sub-)groups. There were no interaction effects of Group with Appetitive State for any of the models. Our findings demonstrate robust feeding-state independent group effects reflecting greater neural activation of specific regions typically associated with reward and cognitive control processing across AN and AtypAN relative to healthy individuals in this food cue paradigm. Differential activation of specific brain regions in response to the passive viewing of high-calorie food images may underlie restrictive eating behavior in this clinical population. |
| first_indexed | 2024-03-13T03:19:08Z |
| format | Article |
| id | doaj.art-687dfa51fe654ab4af007bf3f19aded3 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-03-13T03:19:08Z |
| publishDate | 2023-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-687dfa51fe654ab4af007bf3f19aded32023-06-25T11:29:57ZengNature Publishing GroupTranslational Psychiatry2158-31882023-06-0113111010.1038/s41398-023-02494-3Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controlsKamryn T. Eddy0Franziska Plessow1Lauren Breithaupt2Kendra R. Becker3Meghan Slattery4Christopher J. Mancuso5Alyssa M. Izquierdo6Avery L. Van De Water7Danielle L. Kahn8Melissa J. Dreier9Seda Ebrahimi10Thilo Deckersbach11Jennifer J. Thomas12Laura M. Holsen13Madhusmita Misra14Elizabeth A. Lawson15Eating Disorders Clinical and Research Program, Massachusetts General HospitalNeuroendocrine Unit, Massachusetts General HospitalEating Disorders Clinical and Research Program, Massachusetts General HospitalEating Disorders Clinical and Research Program, Massachusetts General HospitalNeuroendocrine Unit, Massachusetts General HospitalNeuroendocrine Unit, Massachusetts General HospitalNeuroendocrine Unit, Massachusetts General HospitalNeuroendocrine Unit, Massachusetts General HospitalNeuroendocrine Unit, Massachusetts General HospitalEating Disorders Clinical and Research Program, Massachusetts General HospitalCambridge Eating Disorders CenterDepartment of Psychiatry, Harvard Medical SchoolEating Disorders Clinical and Research Program, Massachusetts General HospitalDepartment of Psychiatry, Harvard Medical SchoolNeuroendocrine Unit, Massachusetts General HospitalNeuroendocrine Unit, Massachusetts General HospitalAbstract Anorexia nervosa (AN) and atypical AN (AtypAN) are complex neurobiological illnesses that typically onset in adolescence with an often treatment-refractory and chronic illness trajectory. Aberrant eating behaviors in this population have been linked to abnormalities in food reward and cognitive control, but prior studies have not examined respective contributions of clinical characteristics and metabolic state. Research is needed to identify specific disruptions and inform novel intervention targets to improve outcomes. Fifty-nine females with AN (n = 34) or AtypAN (n = 25), ages 10–22 years, all ≤90% expected body weight, and 34 age-matched healthy controls (HC) completed a well-established neuroimaging food cue paradigm fasting and after a standardized meal, and we used ANCOVA models to investigate main and interaction effects of Group and Appetitive State on blood oxygenation level-dependent (BOLD) activation for the contrast of exposure to high-calorie food images minus objects. We found main effects of Group with greater BOLD activation in the dorsal anterior cingulate cortex (dACC), dorsolateral prefrontal cortex (DLPFC), hippocampus, caudate, and putamen for AN/AtypAN versus HC groups, and in the three-group model including AN, AtypAN, and HC (sub-)groups, where differences were primarily driven by greater activation in the AtypAN subgroup versus HC group. We found a main effect of Appetitive State with increased premeal BOLD activation in the hypothalamus, amygdala, nucleus accumbens, and caudate for models that included AN/AtypAN and HC groups, and in BOLD activation in the nucleus accumbens for the model that included AN, AtypAN, and HC (sub-)groups. There were no interaction effects of Group with Appetitive State for any of the models. Our findings demonstrate robust feeding-state independent group effects reflecting greater neural activation of specific regions typically associated with reward and cognitive control processing across AN and AtypAN relative to healthy individuals in this food cue paradigm. Differential activation of specific brain regions in response to the passive viewing of high-calorie food images may underlie restrictive eating behavior in this clinical population.https://doi.org/10.1038/s41398-023-02494-3 |
| spellingShingle | Kamryn T. Eddy Franziska Plessow Lauren Breithaupt Kendra R. Becker Meghan Slattery Christopher J. Mancuso Alyssa M. Izquierdo Avery L. Van De Water Danielle L. Kahn Melissa J. Dreier Seda Ebrahimi Thilo Deckersbach Jennifer J. Thomas Laura M. Holsen Madhusmita Misra Elizabeth A. Lawson Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls Translational Psychiatry |
| title | Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls |
| title_full | Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls |
| title_fullStr | Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls |
| title_full_unstemmed | Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls |
| title_short | Neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls |
| title_sort | neural activation of regions involved in food reward and cognitive control in young females with anorexia nervosa and atypical anorexia nervosa versus healthy controls |
| url | https://doi.org/10.1038/s41398-023-02494-3 |
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