Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases
Globally, millions of individuals are impacted by neurodegenerative disorders including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD). Although a great deal of energy and financial resources have been invested in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1359453/full |
| _version_ | 1797271393376665600 |
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| author | Lijuan Wang Lijuan Wang Xiansong Fang Baodian Ling Fangsheng Wang Yu Xia Wenjuan Zhang Wenjuan Zhang Tianyu Zhong Tianyu Zhong Xiaoling Wang Xiaoling Wang |
| author_facet | Lijuan Wang Lijuan Wang Xiansong Fang Baodian Ling Fangsheng Wang Yu Xia Wenjuan Zhang Wenjuan Zhang Tianyu Zhong Tianyu Zhong Xiaoling Wang Xiaoling Wang |
| author_sort | Lijuan Wang |
| collection | DOAJ |
| description | Globally, millions of individuals are impacted by neurodegenerative disorders including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD). Although a great deal of energy and financial resources have been invested in disease-related research, breakthroughs in therapeutic approaches remain elusive. The breakdown of cells usually happens together with the onset of neurodegenerative diseases. However, the mechanism that triggers neuronal loss is unknown. Lipid peroxidation, which is iron-dependent, causes a specific type of cell death called ferroptosis, and there is evidence its involvement in the pathogenic cascade of neurodegenerative diseases. However, the specific mechanisms are still not well known. The present article highlights the basic processes that underlie ferroptosis and the corresponding signaling networks. Furthermore, it provides an overview and discussion of current research on the role of ferroptosis across a variety of neurodegenerative conditions. |
| first_indexed | 2024-03-07T14:03:03Z |
| format | Article |
| id | doaj.art-68814c6fa0644a7a8d9c0abc4a9282e1 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-03-07T14:03:03Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-68814c6fa0644a7a8d9c0abc4a9282e12024-03-07T05:01:29ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022024-03-011810.3389/fncel.2024.13594531359453Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseasesLijuan Wang0Lijuan Wang1Xiansong Fang2Baodian Ling3Fangsheng Wang4Yu Xia5Wenjuan Zhang6Wenjuan Zhang7Tianyu Zhong8Tianyu Zhong9Xiaoling Wang10Xiaoling Wang11The First School of Clinical Medicine, Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Blood Transfusion, The First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaThe First School of Clinical Medicine, Gannan Medical University, Ganzhou, ChinaLaboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaGlobally, millions of individuals are impacted by neurodegenerative disorders including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD). Although a great deal of energy and financial resources have been invested in disease-related research, breakthroughs in therapeutic approaches remain elusive. The breakdown of cells usually happens together with the onset of neurodegenerative diseases. However, the mechanism that triggers neuronal loss is unknown. Lipid peroxidation, which is iron-dependent, causes a specific type of cell death called ferroptosis, and there is evidence its involvement in the pathogenic cascade of neurodegenerative diseases. However, the specific mechanisms are still not well known. The present article highlights the basic processes that underlie ferroptosis and the corresponding signaling networks. Furthermore, it provides an overview and discussion of current research on the role of ferroptosis across a variety of neurodegenerative conditions.https://www.frontiersin.org/articles/10.3389/fncel.2024.1359453/fullAlzheimer's diseaseParkinson's diseaseamyotrophic lateral sclerosisHuntington's diseaseferroptosispathological mechanism |
| spellingShingle | Lijuan Wang Lijuan Wang Xiansong Fang Baodian Ling Fangsheng Wang Yu Xia Wenjuan Zhang Wenjuan Zhang Tianyu Zhong Tianyu Zhong Xiaoling Wang Xiaoling Wang Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases Frontiers in Cellular Neuroscience Alzheimer's disease Parkinson's disease amyotrophic lateral sclerosis Huntington's disease ferroptosis pathological mechanism |
| title | Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases |
| title_full | Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases |
| title_fullStr | Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases |
| title_full_unstemmed | Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases |
| title_short | Research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases |
| title_sort | research progress on ferroptosis in the pathogenesis and treatment of neurodegenerative diseases |
| topic | Alzheimer's disease Parkinson's disease amyotrophic lateral sclerosis Huntington's disease ferroptosis pathological mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1359453/full |
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