The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism
Aim:Pulmonary embolism (PE) is a life-threatening condition that requires early diagnosis and treatment. There is still a need for precise and non-invasive biomarkers that can be used to diagnose PE. This study aimed to determine the diagnostic value of Cardiotrophin-1 (CT-1) in patients with acute...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2020-06-01
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| Series: | Eurasian Journal of Emergency Medicine |
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http://akademikaciltip.com/archives/archive-detail/article-preview/the-value-of-cardiotrophin-1-in-the-diagnosis-seve/38710
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| _version_ | 1797919780768841728 |
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| author | Sinan Paslı Olgun Aşık Melih İmamoğlu Mustafa Çiçek Metin Yadigaroğlu Seniz Doğramacı Ahmet Menteşe Mürsel Şahin Özgür Tatlı |
| author_facet | Sinan Paslı Olgun Aşık Melih İmamoğlu Mustafa Çiçek Metin Yadigaroğlu Seniz Doğramacı Ahmet Menteşe Mürsel Şahin Özgür Tatlı |
| author_sort | Sinan Paslı |
| collection | DOAJ |
| description | Aim:Pulmonary embolism (PE) is a life-threatening condition that requires early diagnosis and treatment. There is still a need for precise and non-invasive biomarkers that can be used to diagnose PE. This study aimed to determine the diagnostic value of Cardiotrophin-1 (CT-1) in patients with acute PE and ascertain the relationship between serum CT-1 level and disease prognosis and severity.Materials and Methods:In this prospective study, the serum CT-1 levels of 165 patients with suspected acute PE were measured. The patients were divided into two groups, PE (+) and PE (−), based on their computed tomography angiography results. Their serum CT-1 levels were compared.Results:The CT-1 levels of the PE (+) group (median=4.18 pg/mL, range=3.57-9.55 pg/mL) was non-significantly (p=0.08) different from those of the PE (−) group (median=4.38 pg/mL, range=3.57-51.64 pg/mL). Based on the severity of the condition, there were significant differences (p=0.001) in the CT-1 levels of the patients in the intermediate-low risk group (median=4.19 pg/mL, range=3.62-5.32 pg/mL), intermediate-high risk group (median=4.06 pg/mL, range=3.57-9.31 pg/mL) and high risk group (median=5.01 pg/mL, range=3.89-9.55 pg/ mL). Based on the clinical course, the CT-1 levels of the patients in the good clinical course group (median=4.15 pg/mL, range=3.57-9.31 pg/ ml) were significantly different (p=0.004) from those in the poor clinical course group (median=4.53 pg/mL, range=3.66-9.55 pg/mL).Conclusion:CT-1 level was not observed to be a precise biomarker for the diagnosis of acute PE. However, our study demonstrated that the serum CT-1 levels can be used as a biomarker for ascertaining the severity and prognosis of patients with PE. |
| first_indexed | 2024-04-10T13:51:00Z |
| format | Article |
| id | doaj.art-6881640794c647e68d393568fc4c929a |
| institution | Directory Open Access Journal |
| issn | 2149-5807 2149-6048 |
| language | English |
| last_indexed | 2024-04-10T13:51:00Z |
| publishDate | 2020-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Eurasian Journal of Emergency Medicine |
| spelling | doaj.art-6881640794c647e68d393568fc4c929a2023-02-15T16:10:42ZengGalenos YayineviEurasian Journal of Emergency Medicine2149-58072149-60482020-06-01192717710.4274/eajem.galenos.2020.9206313049054The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary EmbolismSinan Paslı0Olgun Aşık1Melih İmamoğlu2Mustafa Çiçek3Metin Yadigaroğlu4Seniz Doğramacı5Ahmet Menteşe6Mürsel Şahin7Özgür Tatlı8 Gümüşhane State Hospital, Clinic of Emergency Medicine, Gümüşhane, Turkey University of Health Sciences Turkey, Trabzon Kanuni Training and Research Hospital, Clinic of Emergency Medicine Trabzon, Turkey Rize State Hospital, Clinic of Emergency Medicine, Rize, Turkey Bayburt State Hospital, Clinic of Emergency Medicine, Bayburt, Turkey Fatih State Hospital, Clinic of Emergency Medicine, Trabzon, Turkey Karadeniz Technical University, Faculty of Medicine, Department of Medical Biochemistry, Trabzon, Turkey Karadeniz Technical University, Health Services Vocational School, Program of Medical Laboratory Techniques, Trabzon, Turkey Karadeniz Technical University, Faculty of Medicine, Department of Cardiology, Trabzon, Turkey Karadeniz Technical University, Faculty of Medicine, Department of Emergency Medicine, Trabzon, Turkey Aim:Pulmonary embolism (PE) is a life-threatening condition that requires early diagnosis and treatment. There is still a need for precise and non-invasive biomarkers that can be used to diagnose PE. This study aimed to determine the diagnostic value of Cardiotrophin-1 (CT-1) in patients with acute PE and ascertain the relationship between serum CT-1 level and disease prognosis and severity.Materials and Methods:In this prospective study, the serum CT-1 levels of 165 patients with suspected acute PE were measured. The patients were divided into two groups, PE (+) and PE (−), based on their computed tomography angiography results. Their serum CT-1 levels were compared.Results:The CT-1 levels of the PE (+) group (median=4.18 pg/mL, range=3.57-9.55 pg/mL) was non-significantly (p=0.08) different from those of the PE (−) group (median=4.38 pg/mL, range=3.57-51.64 pg/mL). Based on the severity of the condition, there were significant differences (p=0.001) in the CT-1 levels of the patients in the intermediate-low risk group (median=4.19 pg/mL, range=3.62-5.32 pg/mL), intermediate-high risk group (median=4.06 pg/mL, range=3.57-9.31 pg/mL) and high risk group (median=5.01 pg/mL, range=3.89-9.55 pg/ mL). Based on the clinical course, the CT-1 levels of the patients in the good clinical course group (median=4.15 pg/mL, range=3.57-9.31 pg/ ml) were significantly different (p=0.004) from those in the poor clinical course group (median=4.53 pg/mL, range=3.66-9.55 pg/mL).Conclusion:CT-1 level was not observed to be a precise biomarker for the diagnosis of acute PE. However, our study demonstrated that the serum CT-1 levels can be used as a biomarker for ascertaining the severity and prognosis of patients with PE. http://akademikaciltip.com/archives/archive-detail/article-preview/the-value-of-cardiotrophin-1-in-the-diagnosis-seve/38710 pulmonary embolismdiagnosisseverityprognosiscardiotrophin-1 |
| spellingShingle | Sinan Paslı Olgun Aşık Melih İmamoğlu Mustafa Çiçek Metin Yadigaroğlu Seniz Doğramacı Ahmet Menteşe Mürsel Şahin Özgür Tatlı The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism Eurasian Journal of Emergency Medicine pulmonary embolism diagnosis severity prognosis cardiotrophin-1 |
| title | The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism |
| title_full | The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism |
| title_fullStr | The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism |
| title_full_unstemmed | The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism |
| title_short | The Value of Cardiotrophin-1 in the Diagnosis, Severity, and Prognosis of Pulmonary Embolism |
| title_sort | value of cardiotrophin 1 in the diagnosis severity and prognosis of pulmonary embolism |
| topic | pulmonary embolism diagnosis severity prognosis cardiotrophin-1 |
| url |
http://akademikaciltip.com/archives/archive-detail/article-preview/the-value-of-cardiotrophin-1-in-the-diagnosis-seve/38710
|
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