Human Biomonitoring Initiative (HBM4EU): Human Biomonitoring Guidance Values Derived for Dimethylformamide
Within the European Joint Program on Human Biomonitoring HBM4EU, human biomonitoring guidance values (HBM-GVs) for the general population (HBM-GV<sub>GenPop</sub>) or for occupationally exposed adults (HBM-GV<sub>Worker</sub>) are derived for prioritized substances including...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/10/6/298 |
| _version_ | 1797481833778118656 |
|---|---|
| author | Farida Lamkarkach Matthieu Meslin Marike Kolossa-Gehring Petra Apel Robert Garnier |
| author_facet | Farida Lamkarkach Matthieu Meslin Marike Kolossa-Gehring Petra Apel Robert Garnier |
| author_sort | Farida Lamkarkach |
| collection | DOAJ |
| description | Within the European Joint Program on Human Biomonitoring HBM4EU, human biomonitoring guidance values (HBM-GVs) for the general population (HBM-GV<sub>GenPop</sub>) or for occupationally exposed adults (HBM-GV<sub>Worker</sub>) are derived for prioritized substances including dimethylformamide (DMF). The methodology to derive these values that was agreed upon within the HBM4EU project was applied. A large database on DMF exposure from studies conducted at workplaces provided dose–response relationships between biomarker concentrations and health effects. The hepatotoxicity of DMF has been identified as having the most sensitive effect, with increased liver enzyme concentrations serving as biomarkers of the effect. Out of the available biomarkers of DMF exposure studied in this paper, the following were selected to derive HBM-GV<sub>Worker</sub>: total N-methylformamide (tNMF) (sum of N-hydroxymethyl-N-methylformamide and NMF) and N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC) in urine. The proposed HBM-GV<sub>Worker</sub> is 10 mg·L<sup>−1</sup> or 10 mg·g<sup>−1</sup> creatinine for both biomarkers. Due to their different half-lives, tNMF (representative of the exposure of the day) and AMCC (representative of the preceding days’ exposure) are complementary for the biological monitoring of workers exposed to DMF. The levels of confidence for these HBM-GV<sub>Worker</sub> are set to “high” for tNMF and “medium-low” for AMCC. Therefore, further investigations are required for the consolidation of the health-based HBM-GV for AMCC in urine. |
| first_indexed | 2024-03-09T22:20:11Z |
| format | Article |
| id | doaj.art-6889571ea9984db7a9676643a952f461 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T22:20:11Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-6889571ea9984db7a9676643a952f4612023-11-23T19:15:55ZengMDPI AGToxics2305-63042022-05-0110629810.3390/toxics10060298Human Biomonitoring Initiative (HBM4EU): Human Biomonitoring Guidance Values Derived for DimethylformamideFarida Lamkarkach0Matthieu Meslin1Marike Kolossa-Gehring2Petra Apel3Robert Garnier4ANSES 14 Rue Pierre et Marie Curie, 94701 Maisons-Alfort, FranceANSES 14 Rue Pierre et Marie Curie, 94701 Maisons-Alfort, FranceGerman Environment Agency (UBA), Corrensplatz 1, 14195 Berlin, GermanyGerman Environment Agency (UBA), Corrensplatz 1, 14195 Berlin, GermanyParis Poison Centre, Toxicology Department (FeTox), APHP, Lariboisière-Fernand-Widal Hospital, 200 Rue du Faubourg Saint-Denis, 75010 Paris, FranceWithin the European Joint Program on Human Biomonitoring HBM4EU, human biomonitoring guidance values (HBM-GVs) for the general population (HBM-GV<sub>GenPop</sub>) or for occupationally exposed adults (HBM-GV<sub>Worker</sub>) are derived for prioritized substances including dimethylformamide (DMF). The methodology to derive these values that was agreed upon within the HBM4EU project was applied. A large database on DMF exposure from studies conducted at workplaces provided dose–response relationships between biomarker concentrations and health effects. The hepatotoxicity of DMF has been identified as having the most sensitive effect, with increased liver enzyme concentrations serving as biomarkers of the effect. Out of the available biomarkers of DMF exposure studied in this paper, the following were selected to derive HBM-GV<sub>Worker</sub>: total N-methylformamide (tNMF) (sum of N-hydroxymethyl-N-methylformamide and NMF) and N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC) in urine. The proposed HBM-GV<sub>Worker</sub> is 10 mg·L<sup>−1</sup> or 10 mg·g<sup>−1</sup> creatinine for both biomarkers. Due to their different half-lives, tNMF (representative of the exposure of the day) and AMCC (representative of the preceding days’ exposure) are complementary for the biological monitoring of workers exposed to DMF. The levels of confidence for these HBM-GV<sub>Worker</sub> are set to “high” for tNMF and “medium-low” for AMCC. Therefore, further investigations are required for the consolidation of the health-based HBM-GV for AMCC in urine.https://www.mdpi.com/2305-6304/10/6/298HBM4EUdimethylformamideDMFHBM-GVguidance valuebiomarker |
| spellingShingle | Farida Lamkarkach Matthieu Meslin Marike Kolossa-Gehring Petra Apel Robert Garnier Human Biomonitoring Initiative (HBM4EU): Human Biomonitoring Guidance Values Derived for Dimethylformamide Toxics HBM4EU dimethylformamide DMF HBM-GV guidance value biomarker |
| title | Human Biomonitoring Initiative (HBM4EU): Human Biomonitoring Guidance Values Derived for Dimethylformamide |
| title_full | Human Biomonitoring Initiative (HBM4EU): Human Biomonitoring Guidance Values Derived for Dimethylformamide |
| title_fullStr | Human Biomonitoring Initiative (HBM4EU): Human Biomonitoring Guidance Values Derived for Dimethylformamide |
| title_full_unstemmed | Human Biomonitoring Initiative (HBM4EU): Human Biomonitoring Guidance Values Derived for Dimethylformamide |
| title_short | Human Biomonitoring Initiative (HBM4EU): Human Biomonitoring Guidance Values Derived for Dimethylformamide |
| title_sort | human biomonitoring initiative hbm4eu human biomonitoring guidance values derived for dimethylformamide |
| topic | HBM4EU dimethylformamide DMF HBM-GV guidance value biomarker |
| url | https://www.mdpi.com/2305-6304/10/6/298 |
| work_keys_str_mv | AT faridalamkarkach humanbiomonitoringinitiativehbm4euhumanbiomonitoringguidancevaluesderivedfordimethylformamide AT matthieumeslin humanbiomonitoringinitiativehbm4euhumanbiomonitoringguidancevaluesderivedfordimethylformamide AT marikekolossagehring humanbiomonitoringinitiativehbm4euhumanbiomonitoringguidancevaluesderivedfordimethylformamide AT petraapel humanbiomonitoringinitiativehbm4euhumanbiomonitoringguidancevaluesderivedfordimethylformamide AT robertgarnier humanbiomonitoringinitiativehbm4euhumanbiomonitoringguidancevaluesderivedfordimethylformamide |