Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD)
Objective: Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes with no consumption of alcohol. Recently, curcumin is a natural polyphenol found in turmeric has been examined for the treatment of NAFLD. This study aimed to assess the efficacy of 16...
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| Format: | Article |
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Mashhad University of Medical Sciences
2023-11-01
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| Series: | Avicenna Journal of Phytomedicine |
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| Online Access: | https://ajp.mums.ac.ir/article_21919_4f45431dc1bd051efcdf9f08051b06bb.pdf |
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| author | Ali Beheshti Namdar Mitra Ahadi Seyed Mousalreza Hoseini Hassan Vosoghinia Hosein Rajablou Salman Farsi Amirsadra Zangouei Hamid Reza Rahimi |
| author_facet | Ali Beheshti Namdar Mitra Ahadi Seyed Mousalreza Hoseini Hassan Vosoghinia Hosein Rajablou Salman Farsi Amirsadra Zangouei Hamid Reza Rahimi |
| author_sort | Ali Beheshti Namdar |
| collection | DOAJ |
| description | Objective: Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes with no consumption of alcohol. Recently, curcumin is a natural polyphenol found in turmeric has been examined for the treatment of NAFLD. This study aimed to assess the efficacy of 160 mg/day nano-micelle curcumin on the amelioration of NAFLD by measuring liver enzymes.Materials and Methods: Patients with NAFLD were randomly divided into curcumin (intervention group n=33) and placebo (n=33) groups and at the end of the study, the data of 56 participants who completed the 2-month intervention were analyzed. Laboratory tests and questionnaires were used to gather information. Both groups received recommendations for lifestyle modification, and were advised to other necessary advices. Patients in the curcumin group received 160 mg/day of nano-micelle curcumin in two divided doses for 60 days. The 2 groups were followed up for two months and clinical and laboratory indices were compared.Results: Our data showed a significant decrease in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the curcumin group (p<0.01) as well as a significant difference between the groups before and after the intervention in curcumin group (p<0.05). Interestingly, a meaningful decrease in AST serum level was observed in the intervention group (p<0.01). Conclusion: Our study demonstrated that short-term supplementation with nano-micelle curcumin results in the reduction of AST and ALT and is beneficial for the treatment of NAFLD. |
| first_indexed | 2024-03-11T18:18:13Z |
| format | Article |
| id | doaj.art-688bc2ce82aa46d7acd0ec9aacf835d3 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-03-11T18:18:13Z |
| publishDate | 2023-11-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-688bc2ce82aa46d7acd0ec9aacf835d32023-10-16T05:10:38ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492023-11-0113661562510.22038/ajp.2023.2191921919Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD)Ali Beheshti Namdar0Mitra Ahadi1Seyed Mousalreza Hoseini2Hassan Vosoghinia3Hosein Rajablou4Salman Farsi5Amirsadra Zangouei6Hamid Reza Rahimi7Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Medical Genetics & Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranObjective: Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes with no consumption of alcohol. Recently, curcumin is a natural polyphenol found in turmeric has been examined for the treatment of NAFLD. This study aimed to assess the efficacy of 160 mg/day nano-micelle curcumin on the amelioration of NAFLD by measuring liver enzymes.Materials and Methods: Patients with NAFLD were randomly divided into curcumin (intervention group n=33) and placebo (n=33) groups and at the end of the study, the data of 56 participants who completed the 2-month intervention were analyzed. Laboratory tests and questionnaires were used to gather information. Both groups received recommendations for lifestyle modification, and were advised to other necessary advices. Patients in the curcumin group received 160 mg/day of nano-micelle curcumin in two divided doses for 60 days. The 2 groups were followed up for two months and clinical and laboratory indices were compared.Results: Our data showed a significant decrease in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the curcumin group (p<0.01) as well as a significant difference between the groups before and after the intervention in curcumin group (p<0.05). Interestingly, a meaningful decrease in AST serum level was observed in the intervention group (p<0.01). Conclusion: Our study demonstrated that short-term supplementation with nano-micelle curcumin results in the reduction of AST and ALT and is beneficial for the treatment of NAFLD.https://ajp.mums.ac.ir/article_21919_4f45431dc1bd051efcdf9f08051b06bb.pdfnon-alcoholic fatty liver diseasecurcuminnano-micellehepatic enzymes |
| spellingShingle | Ali Beheshti Namdar Mitra Ahadi Seyed Mousalreza Hoseini Hassan Vosoghinia Hosein Rajablou Salman Farsi Amirsadra Zangouei Hamid Reza Rahimi Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD) Avicenna Journal of Phytomedicine non-alcoholic fatty liver disease curcumin nano-micelle hepatic enzymes |
| title | Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD) |
| title_full | Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD) |
| title_fullStr | Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD) |
| title_full_unstemmed | Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD) |
| title_short | Effect of nano-micelle curcumin on hepatic enzymes: A new treatment approach for non-alcoholic fatty liver disease (NAFLD) |
| title_sort | effect of nano micelle curcumin on hepatic enzymes a new treatment approach for non alcoholic fatty liver disease nafld |
| topic | non-alcoholic fatty liver disease curcumin nano-micelle hepatic enzymes |
| url | https://ajp.mums.ac.ir/article_21919_4f45431dc1bd051efcdf9f08051b06bb.pdf |
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