Intermediate Filaments and Polarization in the Intestinal Epithelium
The cytoplasmic intermediate filament cytoskeleton provides a tissue-specific three-dimensional scaffolding with unique context-dependent organizational features. This is particularly apparent in the intestinal epithelium, in which the intermediate filament network is localized below the apical term...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-07-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/5/3/32 |
| _version_ | 1797716520929853440 |
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| author | Richard A. Coch Rudolf E. Leube |
| author_facet | Richard A. Coch Rudolf E. Leube |
| author_sort | Richard A. Coch |
| collection | DOAJ |
| description | The cytoplasmic intermediate filament cytoskeleton provides a tissue-specific three-dimensional scaffolding with unique context-dependent organizational features. This is particularly apparent in the intestinal epithelium, in which the intermediate filament network is localized below the apical terminal web region and is anchored to the apical junction complex. This arrangement is conserved from the nematode Caenorhabditis elegans to humans. The review summarizes compositional, morphological and functional features of the polarized intermediate filament cytoskeleton in intestinal cells of nematodes and mammals. We emphasize the cross talk of intermediate filaments with the actin- and tubulin-based cytoskeleton. Possible links of the intermediate filament system to the distribution of apical membrane proteins and the cell polarity complex are highlighted. Finally, we discuss how these properties relate to the establishment and maintenance of polarity in the intestine. |
| first_indexed | 2024-03-12T08:22:39Z |
| format | Article |
| id | doaj.art-688c4dd12c054f0cb86dca6daab4b94a |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:22:39Z |
| publishDate | 2016-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-688c4dd12c054f0cb86dca6daab4b94a2023-09-02T18:18:57ZengMDPI AGCells2073-44092016-07-01533210.3390/cells5030032cells5030032Intermediate Filaments and Polarization in the Intestinal EpitheliumRichard A. Coch0Rudolf E. Leube1Institute of Molecular and Cellular Anatomy, RWTH Aachen University, Wendlingweg 2, Aachen 52074, GermanyInstitute of Molecular and Cellular Anatomy, RWTH Aachen University, Wendlingweg 2, Aachen 52074, GermanyThe cytoplasmic intermediate filament cytoskeleton provides a tissue-specific three-dimensional scaffolding with unique context-dependent organizational features. This is particularly apparent in the intestinal epithelium, in which the intermediate filament network is localized below the apical terminal web region and is anchored to the apical junction complex. This arrangement is conserved from the nematode Caenorhabditis elegans to humans. The review summarizes compositional, morphological and functional features of the polarized intermediate filament cytoskeleton in intestinal cells of nematodes and mammals. We emphasize the cross talk of intermediate filaments with the actin- and tubulin-based cytoskeleton. Possible links of the intermediate filament system to the distribution of apical membrane proteins and the cell polarity complex are highlighted. Finally, we discuss how these properties relate to the establishment and maintenance of polarity in the intestine.http://www.mdpi.com/2073-4409/5/3/32keratincytokeratinendotubebrush borderC. elegans apical junctiondesmosomeγ-tubulin ring complexatypical protein kinase CPAR proteins |
| spellingShingle | Richard A. Coch Rudolf E. Leube Intermediate Filaments and Polarization in the Intestinal Epithelium Cells keratin cytokeratin endotube brush border C. elegans apical junction desmosome γ-tubulin ring complex atypical protein kinase C PAR proteins |
| title | Intermediate Filaments and Polarization in the Intestinal Epithelium |
| title_full | Intermediate Filaments and Polarization in the Intestinal Epithelium |
| title_fullStr | Intermediate Filaments and Polarization in the Intestinal Epithelium |
| title_full_unstemmed | Intermediate Filaments and Polarization in the Intestinal Epithelium |
| title_short | Intermediate Filaments and Polarization in the Intestinal Epithelium |
| title_sort | intermediate filaments and polarization in the intestinal epithelium |
| topic | keratin cytokeratin endotube brush border C. elegans apical junction desmosome γ-tubulin ring complex atypical protein kinase C PAR proteins |
| url | http://www.mdpi.com/2073-4409/5/3/32 |
| work_keys_str_mv | AT richardacoch intermediatefilamentsandpolarizationintheintestinalepithelium AT rudolfeleube intermediatefilamentsandpolarizationintheintestinalepithelium |