A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy.
Zika virus infection during pregnancy is associated with miscarriage and with a broad spectrum of fetal and neonatal developmental abnormalities collectively known as congenital Zika syndrome (CZS). Symptomology of CZS includes malformations of the brain and skull, neurodevelopmental delay, seizures...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0227676 |
| _version_ | 1819128422261063680 |
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| author | Rosemary J Steinbach Nicole N Haese Jessica L Smith Lois M A Colgin Rhonda P MacAllister Justin M Greene Christopher J Parkins J Beth Kempton Edward Porsov Xiaojie Wang Lauren M Renner Trevor J McGill Brandy L Dozier Craig N Kreklywich Takeshi F Andoh Marjorie R Grafe Heidi L Pecoraro Travis Hodge Robert M Friedman Lisa A Houser Terry K Morgan Peter Stenzel Jonathan R Lindner Robert L Schelonka Jonah B Sacha Victoria H J Roberts Martha Neuringer John V Brigande Christopher D Kroenke Antonio E Frias Anne D Lewis Meredith A Kelleher Alec J Hirsch Daniel Neal Streblow |
| author_facet | Rosemary J Steinbach Nicole N Haese Jessica L Smith Lois M A Colgin Rhonda P MacAllister Justin M Greene Christopher J Parkins J Beth Kempton Edward Porsov Xiaojie Wang Lauren M Renner Trevor J McGill Brandy L Dozier Craig N Kreklywich Takeshi F Andoh Marjorie R Grafe Heidi L Pecoraro Travis Hodge Robert M Friedman Lisa A Houser Terry K Morgan Peter Stenzel Jonathan R Lindner Robert L Schelonka Jonah B Sacha Victoria H J Roberts Martha Neuringer John V Brigande Christopher D Kroenke Antonio E Frias Anne D Lewis Meredith A Kelleher Alec J Hirsch Daniel Neal Streblow |
| author_sort | Rosemary J Steinbach |
| collection | DOAJ |
| description | Zika virus infection during pregnancy is associated with miscarriage and with a broad spectrum of fetal and neonatal developmental abnormalities collectively known as congenital Zika syndrome (CZS). Symptomology of CZS includes malformations of the brain and skull, neurodevelopmental delay, seizures, joint contractures, hearing loss and visual impairment. Previous studies of Zika virus in pregnant rhesus macaques (Macaca mulatta) have described injury to the developing fetus and pregnancy loss, but neonatal outcomes following fetal Zika virus exposure have yet to be characterized in nonhuman primates. Herein we describe the presentation of rhesus macaque neonates with a spectrum of clinical outcomes, including one infant with CZS-like symptoms including cardiomyopathy, motor delay and seizure activity following maternal infection with Zika virus during the first trimester of pregnancy. Further characterization of this neonatal nonhuman primate model of gestational Zika virus infection will provide opportunities to evaluate the efficacy of pre- and postnatal therapeutics for gestational Zika virus infection and CZS. |
| first_indexed | 2024-12-22T08:27:34Z |
| format | Article |
| id | doaj.art-688f3ed75b8e4070a6d4c5a323b83250 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T08:27:34Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-688f3ed75b8e4070a6d4c5a323b832502022-12-21T18:32:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01151e022767610.1371/journal.pone.0227676A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy.Rosemary J SteinbachNicole N HaeseJessica L SmithLois M A ColginRhonda P MacAllisterJustin M GreeneChristopher J ParkinsJ Beth KemptonEdward PorsovXiaojie WangLauren M RennerTrevor J McGillBrandy L DozierCraig N KreklywichTakeshi F AndohMarjorie R GrafeHeidi L PecoraroTravis HodgeRobert M FriedmanLisa A HouserTerry K MorganPeter StenzelJonathan R LindnerRobert L SchelonkaJonah B SachaVictoria H J RobertsMartha NeuringerJohn V BrigandeChristopher D KroenkeAntonio E FriasAnne D LewisMeredith A KelleherAlec J HirschDaniel Neal StreblowZika virus infection during pregnancy is associated with miscarriage and with a broad spectrum of fetal and neonatal developmental abnormalities collectively known as congenital Zika syndrome (CZS). Symptomology of CZS includes malformations of the brain and skull, neurodevelopmental delay, seizures, joint contractures, hearing loss and visual impairment. Previous studies of Zika virus in pregnant rhesus macaques (Macaca mulatta) have described injury to the developing fetus and pregnancy loss, but neonatal outcomes following fetal Zika virus exposure have yet to be characterized in nonhuman primates. Herein we describe the presentation of rhesus macaque neonates with a spectrum of clinical outcomes, including one infant with CZS-like symptoms including cardiomyopathy, motor delay and seizure activity following maternal infection with Zika virus during the first trimester of pregnancy. Further characterization of this neonatal nonhuman primate model of gestational Zika virus infection will provide opportunities to evaluate the efficacy of pre- and postnatal therapeutics for gestational Zika virus infection and CZS.https://doi.org/10.1371/journal.pone.0227676 |
| spellingShingle | Rosemary J Steinbach Nicole N Haese Jessica L Smith Lois M A Colgin Rhonda P MacAllister Justin M Greene Christopher J Parkins J Beth Kempton Edward Porsov Xiaojie Wang Lauren M Renner Trevor J McGill Brandy L Dozier Craig N Kreklywich Takeshi F Andoh Marjorie R Grafe Heidi L Pecoraro Travis Hodge Robert M Friedman Lisa A Houser Terry K Morgan Peter Stenzel Jonathan R Lindner Robert L Schelonka Jonah B Sacha Victoria H J Roberts Martha Neuringer John V Brigande Christopher D Kroenke Antonio E Frias Anne D Lewis Meredith A Kelleher Alec J Hirsch Daniel Neal Streblow A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy. PLoS ONE |
| title | A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy. |
| title_full | A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy. |
| title_fullStr | A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy. |
| title_full_unstemmed | A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy. |
| title_short | A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy. |
| title_sort | neonatal nonhuman primate model of gestational zika virus infection with evidence of microencephaly seizures and cardiomyopathy |
| url | https://doi.org/10.1371/journal.pone.0227676 |
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