Early Outcomes of a High PaO2/FiO2 Ratio during Cardiopulmonary Bypass
Background: In cardiac surgery, supraphysiological oxygen levels are frequently applied perioperatively. In this study, we examined the postoperative effect of perioperative hyperoxemia in cardiac surgery. Methods: All patients who underwent mitral valve replacement via the standard sternotomy m...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2022-04-01
|
| Series: | Journal of Tehran University Heart Center |
| Subjects: | |
| Online Access: | https://jthc.tums.ac.ir/index.php/jthc/article/view/1547 |
| _version_ | 1817969041381261312 |
|---|---|
| author | Hülya Yilmaz AK Yasemin Özşahin Mehmet Ali Yeşiltaş Baris Sandal Ziya Salihoglu Kerem Erkalp |
| author_facet | Hülya Yilmaz AK Yasemin Özşahin Mehmet Ali Yeşiltaş Baris Sandal Ziya Salihoglu Kerem Erkalp |
| author_sort | Hülya Yilmaz AK |
| collection | DOAJ |
| description |
Background: In cardiac surgery, supraphysiological oxygen levels are frequently applied perioperatively. In this study, we examined the postoperative effect of perioperative hyperoxemia in cardiac surgery.
Methods: All patients who underwent mitral valve replacement via the standard sternotomy method between 2010 and 2021 were analyzed by scanning the hospital data system. The patients were divided into 2 groups: the hyperoxemic group (partial pressure of oxygen/fraction of inspired oxygen [PaO2/FiO2] > 500 mmHg) (Group I) and the normoxemic group (300 mmHg < PaO2/FiO2 < 500 mmHg) (Group II) according to the mean of 3 PaO2/FiO2 values calculated by using 3 PaO2 and 3 FiO2 levels. Postoperative complications, the mechanical ventilation time, the need for noninvasive mechanical ventilator support, the length of intensive care unit (ICU) stay, the hospitalization period, and the mortality rate of the groups were compared.
Results: A total of 78 patients were included in the study, and 53 of the patients (67.9%) were female. The mean age of the patients was 58.89±12.60 years. The total mechanical ventilation time was significantly higher in the hyperoxemic group than in Group II (P<0.001) (18.18±12.90 h and 11.45±7.85 h, respectively). The amount of postoperative bleeding was significantly higher in Group I (P=0.003) (539.47±201.74 mL and 417.50±186.93 mL, respectively). The total amount of blood products administered during surgery and ICU stay was higher in Group I (P=0.041) (3.55±1.59 units and 2.87±1.89 units, respectively).
Conclusion: We observed that the group with hyperoxemia during cardiopulmonary bypass had a higher amount of postoperative bleeding and the need for transfusion, as well as a longer duration of mechanical ventilation and intensive care.
|
| first_indexed | 2024-04-13T20:16:22Z |
| format | Article |
| id | doaj.art-688fcb2efc674b52ab14b9901fac5a28 |
| institution | Directory Open Access Journal |
| issn | 1735-8620 2008-2371 |
| language | English |
| last_indexed | 2024-04-13T20:16:22Z |
| publishDate | 2022-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Tehran University Heart Center |
| spelling | doaj.art-688fcb2efc674b52ab14b9901fac5a282022-12-22T02:31:42ZengTehran University of Medical SciencesJournal of Tehran University Heart Center1735-86202008-23712022-04-0117210.18502/jthc.v17i2.9834Early Outcomes of a High PaO2/FiO2 Ratio during Cardiopulmonary BypassHülya Yilmaz AK0Yasemin Özşahin1Mehmet Ali Yeşiltaş2Baris Sandal3Ziya Salihoglu4Kerem Erkalp5Kartal Dr Lütfi Kirdar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.Cerrahpaşa Cardiology Institute, Istanbul University, Istanbul, Turkey.Department of Cardiovascular Surgery, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey.Faculty of Engineering, Istanbul University-Cerrahpaşa, Istanbul, Turkey.Cerrahpaşa Cardiology Institute, Istanbul University, Istanbul, Turkey.Cerrahpaşa Cardiology Institute, Istanbul University, Istanbul, Turkey. Background: In cardiac surgery, supraphysiological oxygen levels are frequently applied perioperatively. In this study, we examined the postoperative effect of perioperative hyperoxemia in cardiac surgery. Methods: All patients who underwent mitral valve replacement via the standard sternotomy method between 2010 and 2021 were analyzed by scanning the hospital data system. The patients were divided into 2 groups: the hyperoxemic group (partial pressure of oxygen/fraction of inspired oxygen [PaO2/FiO2] > 500 mmHg) (Group I) and the normoxemic group (300 mmHg < PaO2/FiO2 < 500 mmHg) (Group II) according to the mean of 3 PaO2/FiO2 values calculated by using 3 PaO2 and 3 FiO2 levels. Postoperative complications, the mechanical ventilation time, the need for noninvasive mechanical ventilator support, the length of intensive care unit (ICU) stay, the hospitalization period, and the mortality rate of the groups were compared. Results: A total of 78 patients were included in the study, and 53 of the patients (67.9%) were female. The mean age of the patients was 58.89±12.60 years. The total mechanical ventilation time was significantly higher in the hyperoxemic group than in Group II (P<0.001) (18.18±12.90 h and 11.45±7.85 h, respectively). The amount of postoperative bleeding was significantly higher in Group I (P=0.003) (539.47±201.74 mL and 417.50±186.93 mL, respectively). The total amount of blood products administered during surgery and ICU stay was higher in Group I (P=0.041) (3.55±1.59 units and 2.87±1.89 units, respectively). Conclusion: We observed that the group with hyperoxemia during cardiopulmonary bypass had a higher amount of postoperative bleeding and the need for transfusion, as well as a longer duration of mechanical ventilation and intensive care. https://jthc.tums.ac.ir/index.php/jthc/article/view/1547OxygenCardiopulmonary bypassMorbidityMortality |
| spellingShingle | Hülya Yilmaz AK Yasemin Özşahin Mehmet Ali Yeşiltaş Baris Sandal Ziya Salihoglu Kerem Erkalp Early Outcomes of a High PaO2/FiO2 Ratio during Cardiopulmonary Bypass Journal of Tehran University Heart Center Oxygen Cardiopulmonary bypass Morbidity Mortality |
| title | Early Outcomes of a High PaO2/FiO2 Ratio during Cardiopulmonary Bypass |
| title_full | Early Outcomes of a High PaO2/FiO2 Ratio during Cardiopulmonary Bypass |
| title_fullStr | Early Outcomes of a High PaO2/FiO2 Ratio during Cardiopulmonary Bypass |
| title_full_unstemmed | Early Outcomes of a High PaO2/FiO2 Ratio during Cardiopulmonary Bypass |
| title_short | Early Outcomes of a High PaO2/FiO2 Ratio during Cardiopulmonary Bypass |
| title_sort | early outcomes of a high pao2 fio2 ratio during cardiopulmonary bypass |
| topic | Oxygen Cardiopulmonary bypass Morbidity Mortality |
| url | https://jthc.tums.ac.ir/index.php/jthc/article/view/1547 |
| work_keys_str_mv | AT hulyayilmazak earlyoutcomesofahighpao2fio2ratioduringcardiopulmonarybypass AT yaseminozsahin earlyoutcomesofahighpao2fio2ratioduringcardiopulmonarybypass AT mehmetaliyesiltas earlyoutcomesofahighpao2fio2ratioduringcardiopulmonarybypass AT barissandal earlyoutcomesofahighpao2fio2ratioduringcardiopulmonarybypass AT ziyasalihoglu earlyoutcomesofahighpao2fio2ratioduringcardiopulmonarybypass AT keremerkalp earlyoutcomesofahighpao2fio2ratioduringcardiopulmonarybypass |