Hypertrophy-Reduced Autophagy Causes Cardiac Dysfunction by Directly Impacting Cardiomyocyte Contractility

Hypertrophy-Reduced Autophagy Causes Cardiac Dysfunction by Directly Impacting Cardiomyocyte Contractility

Cardiac remodeling and contractile dysfunction are leading causes in hypertrophy-associated heart failure (HF), increasing with a population’s rising age. A hallmark of aged and diseased hearts is the accumulation of modified proteins caused by an impaired autophagy-lysosomal-pathway. Although, auto...

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Bibliographic Details
Main Authors: Christiane Ott, Tobias Jung, Sarah Brix, Cathleen John, Iris R. Betz, Anna Foryst-Ludwig, Stefanie Deubel, Wolfgang M. Kuebler, Tilman Grune, Ulrich Kintscher, Jana Grune
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
rapamycin
neonatal cardiomyocyte contractility
TAC
hypertrophy
autophagy
siAtg5
Online Access:https://www.mdpi.com/2073-4409/10/4/805

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