GPCR Pharmacological Profiling of Aaptamine from the Philippine Sponge <i>Stylissa</i> sp. Extends Its Therapeutic Potential for Noncommunicable Diseases
We report the first isolation of the alkaloid aaptamine from the Philippine marine sponge <i>Stylissa</i> sp. Aaptamine possessed weak antiproliferative activity against HCT116 colon cancer cells and inhibited the proteasome in vitro at 50 µM. These activities may be functionally linked....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/18/5618 |