A Review of the Role of an Anthocyanin, Cyanidin-3-<i>O</i>-<i>β</i>-glucoside in Obesity-Related Complications
Obesity has become a major health issue worldwide and obese individuals possess higher levels of adipose tissue when compared with healthy individuals. Obesity is highly associated with the development of different chronic diseases, such as diabetes, cardiovascular diseases, hypertension, cancers, e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/22/3889 |
| _version_ | 1797457970542411776 |
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| author | Ponnuvel Deepa Minji Hong Kandhasamy Sowndhararajan Songmun Kim |
| author_facet | Ponnuvel Deepa Minji Hong Kandhasamy Sowndhararajan Songmun Kim |
| author_sort | Ponnuvel Deepa |
| collection | DOAJ |
| description | Obesity has become a major health issue worldwide and obese individuals possess higher levels of adipose tissue when compared with healthy individuals. Obesity is highly associated with the development of different chronic diseases, such as diabetes, cardiovascular diseases, hypertension, cancers, etc. Previous studies established that anthocyanin compounds play an important role in attenuating obesity-related consequences. Among various anthocyanin compounds, cyanidin-3-<i>O</i>-<i>β</i>-glucoside (C3G) is the most important component and is widely distributed in various colored edible plant materials, especially berries, cherries, black rice, purple corn, etc. In recent decades, several studies have reported the therapeutical properties of C3G. C3G has various biological properties and health benefits, such as antioxidant, antimicrobial, anti-inflammatory, antidiabetic, anti-obesity, neuroprotective, anticancer, etc. In this review, we summarized the in vitro and in vivo studies in relation to the role of C3G in obesity-related complications. Several mechanistic studies demonstrated that C3G maintains the metabolism of glucose, fatty acids, and lipids by regulating different genes and signaling pathways. It could be concluded that the consumption of C3G protects healthy individuals from obesity-related issues by maintaining body weight and regulating their metabolism and energy balance. This review provides some important signaling pathways/targets of C3G to facilitate the prevention and treatment of obesity, leading to the development of important food supplements. |
| first_indexed | 2024-03-09T16:30:25Z |
| format | Article |
| id | doaj.art-6891ba9d8e26426aaf1552e612a12e21 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-09T16:30:25Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-6891ba9d8e26426aaf1552e612a12e212023-11-24T15:02:08ZengMDPI AGPlants2223-77472023-11-011222388910.3390/plants12223889A Review of the Role of an Anthocyanin, Cyanidin-3-<i>O</i>-<i>β</i>-glucoside in Obesity-Related ComplicationsPonnuvel Deepa0Minji Hong1Kandhasamy Sowndhararajan2Songmun Kim3School of Natural Resources and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of KoreaSchool of Natural Resources and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of KoreaDepartment of Botany, Kongunadu Arts and Science College, Coimbatore 641029, IndiaSchool of Natural Resources and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of KoreaObesity has become a major health issue worldwide and obese individuals possess higher levels of adipose tissue when compared with healthy individuals. Obesity is highly associated with the development of different chronic diseases, such as diabetes, cardiovascular diseases, hypertension, cancers, etc. Previous studies established that anthocyanin compounds play an important role in attenuating obesity-related consequences. Among various anthocyanin compounds, cyanidin-3-<i>O</i>-<i>β</i>-glucoside (C3G) is the most important component and is widely distributed in various colored edible plant materials, especially berries, cherries, black rice, purple corn, etc. In recent decades, several studies have reported the therapeutical properties of C3G. C3G has various biological properties and health benefits, such as antioxidant, antimicrobial, anti-inflammatory, antidiabetic, anti-obesity, neuroprotective, anticancer, etc. In this review, we summarized the in vitro and in vivo studies in relation to the role of C3G in obesity-related complications. Several mechanistic studies demonstrated that C3G maintains the metabolism of glucose, fatty acids, and lipids by regulating different genes and signaling pathways. It could be concluded that the consumption of C3G protects healthy individuals from obesity-related issues by maintaining body weight and regulating their metabolism and energy balance. This review provides some important signaling pathways/targets of C3G to facilitate the prevention and treatment of obesity, leading to the development of important food supplements.https://www.mdpi.com/2223-7747/12/22/3889anthocyanincyanidin-3-<i>O</i>-<i>β</i>-glucosidecyanidin-3-glucosideobesityadipogenesisadipocyte |
| spellingShingle | Ponnuvel Deepa Minji Hong Kandhasamy Sowndhararajan Songmun Kim A Review of the Role of an Anthocyanin, Cyanidin-3-<i>O</i>-<i>β</i>-glucoside in Obesity-Related Complications Plants anthocyanin cyanidin-3-<i>O</i>-<i>β</i>-glucoside cyanidin-3-glucoside obesity adipogenesis adipocyte |
| title | A Review of the Role of an Anthocyanin, Cyanidin-3-<i>O</i>-<i>β</i>-glucoside in Obesity-Related Complications |
| title_full | A Review of the Role of an Anthocyanin, Cyanidin-3-<i>O</i>-<i>β</i>-glucoside in Obesity-Related Complications |
| title_fullStr | A Review of the Role of an Anthocyanin, Cyanidin-3-<i>O</i>-<i>β</i>-glucoside in Obesity-Related Complications |
| title_full_unstemmed | A Review of the Role of an Anthocyanin, Cyanidin-3-<i>O</i>-<i>β</i>-glucoside in Obesity-Related Complications |
| title_short | A Review of the Role of an Anthocyanin, Cyanidin-3-<i>O</i>-<i>β</i>-glucoside in Obesity-Related Complications |
| title_sort | review of the role of an anthocyanin cyanidin 3 i o i i β i glucoside in obesity related complications |
| topic | anthocyanin cyanidin-3-<i>O</i>-<i>β</i>-glucoside cyanidin-3-glucoside obesity adipogenesis adipocyte |
| url | https://www.mdpi.com/2223-7747/12/22/3889 |
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