Distinct spatiotemporal patterns of cortical thinning in Alzheimer’s disease-type cognitive impairment and subcortical vascular cognitive impairment
Abstract Previous studies on Alzheimer’s disease-type cognitive impairment (ADCI) and subcortical vascular cognitive impairment (SVCI) has rarely explored spatiotemporal heterogeneity. This study aims to identify distinct spatiotemporal cortical atrophy patterns in ADCI and SVCI. 1,338 participants...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-05787-5 |
| _version_ | 1797273531554201600 |
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| author | Jinhee Kim Jonghoon Kim Yu-hyun Park Heejin Yoo Jun Pyo Kim Hyemin Jang Hyunjin Park Sang Won Seo |
| author_facet | Jinhee Kim Jonghoon Kim Yu-hyun Park Heejin Yoo Jun Pyo Kim Hyemin Jang Hyunjin Park Sang Won Seo |
| author_sort | Jinhee Kim |
| collection | DOAJ |
| description | Abstract Previous studies on Alzheimer’s disease-type cognitive impairment (ADCI) and subcortical vascular cognitive impairment (SVCI) has rarely explored spatiotemporal heterogeneity. This study aims to identify distinct spatiotemporal cortical atrophy patterns in ADCI and SVCI. 1,338 participants (713 ADCI, 208 SVCI, and 417 cognitively unimpaired elders) underwent brain magnetic resonance imaging (MRI), amyloid positron emission tomography, and neuropsychological tests. Using MRI, this study measures cortical thickness in five brain regions (medial temporal, inferior temporal, posterior medial parietal, lateral parietal, and frontal areas) and utilizes the Subtype and Stage Inference (SuStaIn) model to predict the most probable subtype and stage for each participant. SuStaIn identifies two distinct cortical thinning patterns in ADCI (medial temporal: 65.8%, diffuse: 34.2%) and SVCI (frontotemporal: 47.1%, parietal: 52.9%) patients. The medial temporal subtype of ADCI shows a faster decline in attention, visuospatial, visual memory, and frontal/executive domains than the diffuse subtype (p-value < 0.01). However, there are no significant differences in longitudinal cognitive outcomes between the two subtypes of SVCI. Our study provides valuable insights into the distinct spatiotemporal patterns of cortical thinning in patients with ADCI and SVCI, suggesting the potential for individualized therapeutic and preventive strategies to improve clinical outcomes. |
| first_indexed | 2024-03-07T14:45:42Z |
| format | Article |
| id | doaj.art-6893f09471514a10a9b1ccb566fd3696 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-07T14:45:42Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-6893f09471514a10a9b1ccb566fd36962024-03-05T19:59:36ZengNature PortfolioCommunications Biology2399-36422024-02-017111010.1038/s42003-024-05787-5Distinct spatiotemporal patterns of cortical thinning in Alzheimer’s disease-type cognitive impairment and subcortical vascular cognitive impairmentJinhee Kim0Jonghoon Kim1Yu-hyun Park2Heejin Yoo3Jun Pyo Kim4Hyemin Jang5Hyunjin Park6Sang Won Seo7Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Electrical and Computer Engineering, Sungkyunkwan UniversityDepartments of Neurology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartments of Neurology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartments of Neurology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartments of Neurology, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Electrical and Computer Engineering, Sungkyunkwan UniversityDepartments of Neurology, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract Previous studies on Alzheimer’s disease-type cognitive impairment (ADCI) and subcortical vascular cognitive impairment (SVCI) has rarely explored spatiotemporal heterogeneity. This study aims to identify distinct spatiotemporal cortical atrophy patterns in ADCI and SVCI. 1,338 participants (713 ADCI, 208 SVCI, and 417 cognitively unimpaired elders) underwent brain magnetic resonance imaging (MRI), amyloid positron emission tomography, and neuropsychological tests. Using MRI, this study measures cortical thickness in five brain regions (medial temporal, inferior temporal, posterior medial parietal, lateral parietal, and frontal areas) and utilizes the Subtype and Stage Inference (SuStaIn) model to predict the most probable subtype and stage for each participant. SuStaIn identifies two distinct cortical thinning patterns in ADCI (medial temporal: 65.8%, diffuse: 34.2%) and SVCI (frontotemporal: 47.1%, parietal: 52.9%) patients. The medial temporal subtype of ADCI shows a faster decline in attention, visuospatial, visual memory, and frontal/executive domains than the diffuse subtype (p-value < 0.01). However, there are no significant differences in longitudinal cognitive outcomes between the two subtypes of SVCI. Our study provides valuable insights into the distinct spatiotemporal patterns of cortical thinning in patients with ADCI and SVCI, suggesting the potential for individualized therapeutic and preventive strategies to improve clinical outcomes.https://doi.org/10.1038/s42003-024-05787-5 |
| spellingShingle | Jinhee Kim Jonghoon Kim Yu-hyun Park Heejin Yoo Jun Pyo Kim Hyemin Jang Hyunjin Park Sang Won Seo Distinct spatiotemporal patterns of cortical thinning in Alzheimer’s disease-type cognitive impairment and subcortical vascular cognitive impairment Communications Biology |
| title | Distinct spatiotemporal patterns of cortical thinning in Alzheimer’s disease-type cognitive impairment and subcortical vascular cognitive impairment |
| title_full | Distinct spatiotemporal patterns of cortical thinning in Alzheimer’s disease-type cognitive impairment and subcortical vascular cognitive impairment |
| title_fullStr | Distinct spatiotemporal patterns of cortical thinning in Alzheimer’s disease-type cognitive impairment and subcortical vascular cognitive impairment |
| title_full_unstemmed | Distinct spatiotemporal patterns of cortical thinning in Alzheimer’s disease-type cognitive impairment and subcortical vascular cognitive impairment |
| title_short | Distinct spatiotemporal patterns of cortical thinning in Alzheimer’s disease-type cognitive impairment and subcortical vascular cognitive impairment |
| title_sort | distinct spatiotemporal patterns of cortical thinning in alzheimer s disease type cognitive impairment and subcortical vascular cognitive impairment |
| url | https://doi.org/10.1038/s42003-024-05787-5 |
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