Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states

Full-length Bruton’s tyrosine kinase (BTK) has been refractory to structural analysis. The nearest full-length structure of BTK to date consists of the autoinhibited SH3–SH2–kinase core. Precisely how the BTK N-terminal domains (the Pleckstrin homology/Tec homology [PHTH] domain and proline-rich reg...

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Bibliográfalaš dieđut
Váldodahkkit: David Yin-wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: eLife Sciences Publications Ltd 2024-01-01
Ráidu:eLife
Fáttát:
BTK
kinase regulation
conformational states
kinase structure
Liŋkkat:https://elifesciences.org/articles/89489

Interneahtta

https://elifesciences.org/articles/89489

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