Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization
The persistence of symptoms beyond three months after COVID-19 infection, often referred to as post-COVID-19 condition (PCC), is commonly experienced. It is hypothesized that PCC results from autonomic dysfunction with decreased vagal nerve activity, which can be indexed by low heart rate variabilit...
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MDPI AG
2023-02-01
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| Online Access: | https://www.mdpi.com/1424-8220/23/5/2473 |
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| author | Estelle A. M. C. Adang Maud T. A. Strous Joop P. van den Bergh Debbie Gach Vivian E. M. van Kampen Roel E. P. van Zeeland Dennis G. Barten Frits H. M. van Osch |
| author_facet | Estelle A. M. C. Adang Maud T. A. Strous Joop P. van den Bergh Debbie Gach Vivian E. M. van Kampen Roel E. P. van Zeeland Dennis G. Barten Frits H. M. van Osch |
| author_sort | Estelle A. M. C. Adang |
| collection | DOAJ |
| description | The persistence of symptoms beyond three months after COVID-19 infection, often referred to as post-COVID-19 condition (PCC), is commonly experienced. It is hypothesized that PCC results from autonomic dysfunction with decreased vagal nerve activity, which can be indexed by low heart rate variability (HRV). The aim of this study was to assess the association of HRV upon admission with pulmonary function impairment and the number of reported symptoms beyond three months after initial hospitalization for COVID-19 between February and December 2020. Follow-up took place three to five months after discharge and included pulmonary function tests and the assessment of persistent symptoms. HRV analysis was performed on one 10 s electrocardiogram obtained upon admission. Analyses were performed using multivariable and multinomial logistic regression models. Among 171 patients who received follow-up, and with an electrocardiogram at admission, decreased diffusion capacity of the lung for carbon monoxide (DLCO) (41%) was most frequently found. After a median of 119 days (IQR 101–141), 81% of the participants reported at least one symptom. HRV was not associated with pulmonary function impairment or persistent symptoms three to five months after hospitalization for COVID-19. |
| first_indexed | 2024-03-11T07:11:25Z |
| format | Article |
| id | doaj.art-689757bfe56b4c8795703b8d538fd965 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-11T07:11:25Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-689757bfe56b4c8795703b8d538fd9652023-11-17T08:35:16ZengMDPI AGSensors1424-82202023-02-01235247310.3390/s23052473Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 HospitalizationEstelle A. M. C. Adang0Maud T. A. Strous1Joop P. van den Bergh2Debbie Gach3Vivian E. M. van Kampen4Roel E. P. van Zeeland5Dennis G. Barten6Frits H. M. van Osch7Department of Emergency Medicine, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsDepartment of Internal Medicine, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsDepartment of Internal Medicine, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsNUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6229 ER Maastricht, The NetherlandsDepartment of Pulmonology, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsDepartment of Pulmonology, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsDepartment of Emergency Medicine, VieCuri Medical Centre, 5912 BL Venlo, The NetherlandsNUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6229 ER Maastricht, The NetherlandsThe persistence of symptoms beyond three months after COVID-19 infection, often referred to as post-COVID-19 condition (PCC), is commonly experienced. It is hypothesized that PCC results from autonomic dysfunction with decreased vagal nerve activity, which can be indexed by low heart rate variability (HRV). The aim of this study was to assess the association of HRV upon admission with pulmonary function impairment and the number of reported symptoms beyond three months after initial hospitalization for COVID-19 between February and December 2020. Follow-up took place three to five months after discharge and included pulmonary function tests and the assessment of persistent symptoms. HRV analysis was performed on one 10 s electrocardiogram obtained upon admission. Analyses were performed using multivariable and multinomial logistic regression models. Among 171 patients who received follow-up, and with an electrocardiogram at admission, decreased diffusion capacity of the lung for carbon monoxide (DLCO) (41%) was most frequently found. After a median of 119 days (IQR 101–141), 81% of the participants reported at least one symptom. HRV was not associated with pulmonary function impairment or persistent symptoms three to five months after hospitalization for COVID-19.https://www.mdpi.com/1424-8220/23/5/2473heart rate variabilityCOVID-19post-COVID-19 conditionlong COVIDautonomic dysfunctionvagal nerve activity |
| spellingShingle | Estelle A. M. C. Adang Maud T. A. Strous Joop P. van den Bergh Debbie Gach Vivian E. M. van Kampen Roel E. P. van Zeeland Dennis G. Barten Frits H. M. van Osch Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization Sensors heart rate variability COVID-19 post-COVID-19 condition long COVID autonomic dysfunction vagal nerve activity |
| title | Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization |
| title_full | Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization |
| title_fullStr | Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization |
| title_full_unstemmed | Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization |
| title_short | Association of Heart Rate Variability with Pulmonary Function Impairment and Symptomatology Post-COVID-19 Hospitalization |
| title_sort | association of heart rate variability with pulmonary function impairment and symptomatology post covid 19 hospitalization |
| topic | heart rate variability COVID-19 post-COVID-19 condition long COVID autonomic dysfunction vagal nerve activity |
| url | https://www.mdpi.com/1424-8220/23/5/2473 |
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