The role of TREM2 in Alzheimer’s disease: from the perspective of Tau
Triggering receptor expressed on myeloid cells 2 (TREM2), a pattern recognition receptor abundantly expressed on microglia, has been identified as one of the risk factors for Alzheimer’s disease (AD). Several studies have already demonstrated the relationship between TREM2 and Tau. TREM2 mutations a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1280257/full |
| _version_ | 1797632926881415168 |
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| author | Wendi Huang Juan Huang Nanqu Huang Yong Luo |
| author_facet | Wendi Huang Juan Huang Nanqu Huang Yong Luo |
| author_sort | Wendi Huang |
| collection | DOAJ |
| description | Triggering receptor expressed on myeloid cells 2 (TREM2), a pattern recognition receptor abundantly expressed on microglia, has been identified as one of the risk factors for Alzheimer’s disease (AD). Several studies have already demonstrated the relationship between TREM2 and Tau. TREM2 mutations and altered expression play an important role in Tau phosphorylation. Furthermore, the level of Tau phosphorylation is correlated with soluble TREM2 (sTREM2). However, in different stages of AD, TREM2 seems to have varying effects on Tau pathology. The explicit interaction between TREM2 and Tau, as well as how they affect AD pathology, remains unclear, and there is much evidence to the contrary that requires rational interpretation. Reviewing the dual roles of TREM2 in AD will help identify a more appropriate development strategy for targeting TREM2 to treat AD. Therefore, this review focuses on the interplay between Tau and TREM2 in relation to AD. |
| first_indexed | 2024-03-11T11:44:35Z |
| format | Article |
| id | doaj.art-6897852f49f34d0ab3e161c8d560640a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-11T11:44:35Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-6897852f49f34d0ab3e161c8d560640a2023-11-09T16:08:24ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-11-011110.3389/fcell.2023.12802571280257The role of TREM2 in Alzheimer’s disease: from the perspective of TauWendi Huang0Juan Huang1Nanqu Huang2Yong Luo3Department of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, ChinaKey Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Lab of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, ChinaNational Drug Clinical Trial Institution, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, ChinaDepartment of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, ChinaTriggering receptor expressed on myeloid cells 2 (TREM2), a pattern recognition receptor abundantly expressed on microglia, has been identified as one of the risk factors for Alzheimer’s disease (AD). Several studies have already demonstrated the relationship between TREM2 and Tau. TREM2 mutations and altered expression play an important role in Tau phosphorylation. Furthermore, the level of Tau phosphorylation is correlated with soluble TREM2 (sTREM2). However, in different stages of AD, TREM2 seems to have varying effects on Tau pathology. The explicit interaction between TREM2 and Tau, as well as how they affect AD pathology, remains unclear, and there is much evidence to the contrary that requires rational interpretation. Reviewing the dual roles of TREM2 in AD will help identify a more appropriate development strategy for targeting TREM2 to treat AD. Therefore, this review focuses on the interplay between Tau and TREM2 in relation to AD.https://www.frontiersin.org/articles/10.3389/fcell.2023.1280257/fullAlzheimer’s diseasetriggering receptor expressed on myeloid cells 2TauTau pathologysoluble TREM2microglia |
| spellingShingle | Wendi Huang Juan Huang Nanqu Huang Yong Luo The role of TREM2 in Alzheimer’s disease: from the perspective of Tau Frontiers in Cell and Developmental Biology Alzheimer’s disease triggering receptor expressed on myeloid cells 2 Tau Tau pathology soluble TREM2 microglia |
| title | The role of TREM2 in Alzheimer’s disease: from the perspective of Tau |
| title_full | The role of TREM2 in Alzheimer’s disease: from the perspective of Tau |
| title_fullStr | The role of TREM2 in Alzheimer’s disease: from the perspective of Tau |
| title_full_unstemmed | The role of TREM2 in Alzheimer’s disease: from the perspective of Tau |
| title_short | The role of TREM2 in Alzheimer’s disease: from the perspective of Tau |
| title_sort | role of trem2 in alzheimer s disease from the perspective of tau |
| topic | Alzheimer’s disease triggering receptor expressed on myeloid cells 2 Tau Tau pathology soluble TREM2 microglia |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1280257/full |
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