Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry
Waldemar Brola,1 Piotr Sobolewski,2 Małgorzata Fudala,1 Stanisław Flaga,3 Konrad Jantarski,4 Danuta Ryglewicz,5 Andrzej Potemkowski6 1Department of Neurology, Specialist Hospital, Końskie, 2Department of Neurology, Holy Spirit Specialist Hospital, Sandomierz, 3AGH University of Science and Technolo...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2016-08-01
|
| Series: | Patient Preference and Adherence |
| Subjects: | |
| Online Access: | https://www.dovepress.com/self-reported-quality-of-life-in-multiple-sclerosis-patients-prelimina-peer-reviewed-article-PPA |
| _version_ | 1818539226040369152 |
|---|---|
| author | Brola W Sobolewski P Fudala M Flaga S Jantarski K Ryglewicz D Potemkowski A, |
| author_facet | Brola W Sobolewski P Fudala M Flaga S Jantarski K Ryglewicz D Potemkowski A, |
| author_sort | Brola W |
| collection | DOAJ |
| description | Waldemar Brola,1 Piotr Sobolewski,2 Małgorzata Fudala,1 Stanisław Flaga,3 Konrad Jantarski,4 Danuta Ryglewicz,5 Andrzej Potemkowski6 1Department of Neurology, Specialist Hospital, Końskie, 2Department of Neurology, Holy Spirit Specialist Hospital, Sandomierz, 3AGH University of Science and Technology, Krakow, 4Swietokrzyski Regional Branch of the Polish National Health Fund (NFZ), Kielce, 5First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, 6Department of Psychology, University of Szczecin, Szczecin, Poland Background: The aim of the study was to analyze selected clinical and sociodemographic factors and their effects on the quality of life (QoL) of multiple sclerosis (MS) patients registered in the Polish MS Registry.Methods: This was a cross-sectional observational study performed in Poland. Data on personal and disease-specific factors were collected between January 1, 2011, and December 31, 2015, via the web portal of the Polish MS Registry. All patients were assessed by a physician and asked to complete the Polish language versions of the following self-evaluation questionnaires: EuroQol 5-Dimensions, EuroQoL Visual Analog Scale, and Multiple Sclerosis Impact Scale. Univariate analysis and logistic regression were performed to determine the factors associated with QoL.Results: The study included 2,385 patients (female/male ratio 2.3:1) with clinically confirmed MS (mean age 37.8±9.2 years). Average EuroQol 5-Dimensions index was 0.72±0.24, and the mean EuroQoL Visual Analog Scale score was 64.2±22.8. The average Multiple Sclerosis Impact Scale score was 84.6±11.2 (62.2±18.4 for physical condition and 23.8±7.2 for mental condition). Lower QoL scores were significantly associated with higher level of disability (odds ratio [OR], 0.932; 95% confidence interval [CI], 0.876–0.984; P=0.001), age >40 years (OR, 1.042; 95% CI, 0.924–1.158; P=0.012), longer disease duration (OR, 0.482; 95% CI, 0.224–0.998; P=0.042), and lack of disease modifying therapies (OR, 0.024; 95% CI, 0.160–0.835; P=0.024). No significant associations were found between QoL, sex, type of MS course, patient’s education, and marital status.Conclusion: The Polish MS Registry is the first national registry for long-term observation that allows for self-evaluation of the QoL. QoL of Polish patients with MS is significantly lower compared with the rest of the population. The parameter is mainly affected by the level of disability, duration of the disease, and limited access to immunomodulatory therapy. Keywords: multiple sclerosis, patient-reported outcomes, quality of life, Poland |
| first_indexed | 2024-12-11T21:39:15Z |
| format | Article |
| id | doaj.art-68979bb41b9a4437953b58ef1a2234de |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-12-11T21:39:15Z |
| publishDate | 2016-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-68979bb41b9a4437953b58ef1a2234de2022-12-22T00:49:54ZengDove Medical PressPatient Preference and Adherence1177-889X2016-08-01Volume 101647165628616Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS RegistryBrola WSobolewski PFudala MFlaga SJantarski KRyglewicz DPotemkowski A,Waldemar Brola,1 Piotr Sobolewski,2 Małgorzata Fudala,1 Stanisław Flaga,3 Konrad Jantarski,4 Danuta Ryglewicz,5 Andrzej Potemkowski6 1Department of Neurology, Specialist Hospital, Końskie, 2Department of Neurology, Holy Spirit Specialist Hospital, Sandomierz, 3AGH University of Science and Technology, Krakow, 4Swietokrzyski Regional Branch of the Polish National Health Fund (NFZ), Kielce, 5First Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, 6Department of Psychology, University of Szczecin, Szczecin, Poland Background: The aim of the study was to analyze selected clinical and sociodemographic factors and their effects on the quality of life (QoL) of multiple sclerosis (MS) patients registered in the Polish MS Registry.Methods: This was a cross-sectional observational study performed in Poland. Data on personal and disease-specific factors were collected between January 1, 2011, and December 31, 2015, via the web portal of the Polish MS Registry. All patients were assessed by a physician and asked to complete the Polish language versions of the following self-evaluation questionnaires: EuroQol 5-Dimensions, EuroQoL Visual Analog Scale, and Multiple Sclerosis Impact Scale. Univariate analysis and logistic regression were performed to determine the factors associated with QoL.Results: The study included 2,385 patients (female/male ratio 2.3:1) with clinically confirmed MS (mean age 37.8±9.2 years). Average EuroQol 5-Dimensions index was 0.72±0.24, and the mean EuroQoL Visual Analog Scale score was 64.2±22.8. The average Multiple Sclerosis Impact Scale score was 84.6±11.2 (62.2±18.4 for physical condition and 23.8±7.2 for mental condition). Lower QoL scores were significantly associated with higher level of disability (odds ratio [OR], 0.932; 95% confidence interval [CI], 0.876–0.984; P=0.001), age >40 years (OR, 1.042; 95% CI, 0.924–1.158; P=0.012), longer disease duration (OR, 0.482; 95% CI, 0.224–0.998; P=0.042), and lack of disease modifying therapies (OR, 0.024; 95% CI, 0.160–0.835; P=0.024). No significant associations were found between QoL, sex, type of MS course, patient’s education, and marital status.Conclusion: The Polish MS Registry is the first national registry for long-term observation that allows for self-evaluation of the QoL. QoL of Polish patients with MS is significantly lower compared with the rest of the population. The parameter is mainly affected by the level of disability, duration of the disease, and limited access to immunomodulatory therapy. Keywords: multiple sclerosis, patient-reported outcomes, quality of life, Polandhttps://www.dovepress.com/self-reported-quality-of-life-in-multiple-sclerosis-patients-prelimina-peer-reviewed-article-PPAmultiple sclerosispatient-reported outcomesquality of lifePoland |
| spellingShingle | Brola W Sobolewski P Fudala M Flaga S Jantarski K Ryglewicz D Potemkowski A, Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry Patient Preference and Adherence multiple sclerosis patient-reported outcomes quality of life Poland |
| title | Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry |
| title_full | Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry |
| title_fullStr | Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry |
| title_full_unstemmed | Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry |
| title_short | Self-reported quality of life in multiple sclerosis patients: preliminary results based on the Polish MS Registry |
| title_sort | self reported quality of life in multiple sclerosis patients preliminary results based on the polish ms registry |
| topic | multiple sclerosis patient-reported outcomes quality of life Poland |
| url | https://www.dovepress.com/self-reported-quality-of-life-in-multiple-sclerosis-patients-prelimina-peer-reviewed-article-PPA |
| work_keys_str_mv | AT brolaw selfreportedqualityoflifeinmultiplesclerosispatientspreliminaryresultsbasedonthepolishmsregistry AT sobolewskip selfreportedqualityoflifeinmultiplesclerosispatientspreliminaryresultsbasedonthepolishmsregistry AT fudalam selfreportedqualityoflifeinmultiplesclerosispatientspreliminaryresultsbasedonthepolishmsregistry AT flagas selfreportedqualityoflifeinmultiplesclerosispatientspreliminaryresultsbasedonthepolishmsregistry AT jantarskik selfreportedqualityoflifeinmultiplesclerosispatientspreliminaryresultsbasedonthepolishmsregistry AT ryglewiczd selfreportedqualityoflifeinmultiplesclerosispatientspreliminaryresultsbasedonthepolishmsregistry AT potemkowskia selfreportedqualityoflifeinmultiplesclerosispatientspreliminaryresultsbasedonthepolishmsregistry |