The Role of Contactin 1 in Cancers: What We Know So Far
Cancers are among the difficult-to-treat diseases despite advances in diagnosis and treatment. Although newer effective targets remain to be discovered, targeted therapy has emerged as a promising field. In the last decade, contactin 1 (CNTN1) has surfaced as an important cancer-related molecule. CN...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.574208/full |
| _version_ | 1818315666690670592 |
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| author | Yumei Liang Cui Ma Fengjuan Li Guanhua Nie Haining Zhang |
| author_facet | Yumei Liang Cui Ma Fengjuan Li Guanhua Nie Haining Zhang |
| author_sort | Yumei Liang |
| collection | DOAJ |
| description | Cancers are among the difficult-to-treat diseases despite advances in diagnosis and treatment. Although newer effective targets remain to be discovered, targeted therapy has emerged as a promising field. In the last decade, contactin 1 (CNTN1) has surfaced as an important cancer-related molecule. CNTN1 is a neuronal membrane glycoprotein, which, if overexpressed, is found in different cancer cell lines, cancer tissues, and transgenic mice. It is positively associated with lymphatic invasion, metastasis, late TNM stage, and a short overall survival time. However, the role of CNTN1 in cancer cell proliferation remains unclear. In addition, CNTN1 is involved in cancer cell invasion, migration, metastasis, and chemoresistance by promoting epithelial-mesenchymal transition and mediating several signal transduction pathways. Several studies suggest CNTN1 as a new therapeutic target for cancers. This review aims to summarize the research developments on CNTN1 in various cancers, to establish its role in epithelial-mesenchymal transition and signal transduction pathways, and to identify promising areas for further investigation. |
| first_indexed | 2024-12-13T09:09:10Z |
| format | Article |
| id | doaj.art-689854e1b5cd4c4bae554776b7ade5fd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T09:09:10Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-689854e1b5cd4c4bae554776b7ade5fd2022-12-21T23:52:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.574208574208The Role of Contactin 1 in Cancers: What We Know So FarYumei Liang0Cui Ma1Fengjuan Li2Guanhua Nie3Haining Zhang4Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Pediatric Hematology, The First Hospital of Jilin University, Changchun, ChinaOncology Department of Tumor Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, ChinaCancers are among the difficult-to-treat diseases despite advances in diagnosis and treatment. Although newer effective targets remain to be discovered, targeted therapy has emerged as a promising field. In the last decade, contactin 1 (CNTN1) has surfaced as an important cancer-related molecule. CNTN1 is a neuronal membrane glycoprotein, which, if overexpressed, is found in different cancer cell lines, cancer tissues, and transgenic mice. It is positively associated with lymphatic invasion, metastasis, late TNM stage, and a short overall survival time. However, the role of CNTN1 in cancer cell proliferation remains unclear. In addition, CNTN1 is involved in cancer cell invasion, migration, metastasis, and chemoresistance by promoting epithelial-mesenchymal transition and mediating several signal transduction pathways. Several studies suggest CNTN1 as a new therapeutic target for cancers. This review aims to summarize the research developments on CNTN1 in various cancers, to establish its role in epithelial-mesenchymal transition and signal transduction pathways, and to identify promising areas for further investigation.https://www.frontiersin.org/articles/10.3389/fonc.2020.574208/fullcontactin 1 (CNTN1)cancersepithelial-mesenchymal transition (EMT)PI3K/AKTsignal transduction pathwaystargeted therapy |
| spellingShingle | Yumei Liang Cui Ma Fengjuan Li Guanhua Nie Haining Zhang The Role of Contactin 1 in Cancers: What We Know So Far Frontiers in Oncology contactin 1 (CNTN1) cancers epithelial-mesenchymal transition (EMT) PI3K/AKT signal transduction pathways targeted therapy |
| title | The Role of Contactin 1 in Cancers: What We Know So Far |
| title_full | The Role of Contactin 1 in Cancers: What We Know So Far |
| title_fullStr | The Role of Contactin 1 in Cancers: What We Know So Far |
| title_full_unstemmed | The Role of Contactin 1 in Cancers: What We Know So Far |
| title_short | The Role of Contactin 1 in Cancers: What We Know So Far |
| title_sort | role of contactin 1 in cancers what we know so far |
| topic | contactin 1 (CNTN1) cancers epithelial-mesenchymal transition (EMT) PI3K/AKT signal transduction pathways targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.574208/full |
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