One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics

One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics

T-cell engaging biologics is a class of novel and promising immune-oncology compounds that leverage the immune system to eradicate cancer. Here, we compared and contrasted a bispecific diabody-Fc format, which displays a relatively short antigen-binding arm distance, with our bispecific IgG platform...

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Bibliographic Details
Main Authors: Wei Chen, Fan Yang, Carole Wang, Jatin Narula, Edward Pascua, Irene Ni, Sheng Ding, Xiaodi Deng, Matthew Ling-Hon Chu, Amber Pham, Xiaoyue Jiang, Kevin C. Lindquist, Patrick J. Doonan, Tom Van Blarcom, Yik Andy Yeung, Javier Chaparro-Riggers
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:mAbs
Subjects:
Bispecific engineering
cd3
t-cell engager
therapeutic window
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1871171

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