A Candidemia Case Caused by a Novel Drug-Resistant Candida auris with the Y132F Mutation in Erg11 in Mainland China
Zhaoxia Xu,1,* Lei Zhang,2,* Ran Han,1 Chengwei Ding,1 Haochang Shou,1 Xueguang Duan,1 Shengwei Zhang1 1Department of Clinical Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2State Key Laboratory of Pathogen and Biosecurity...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-05-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-candidemia-case-caused-by-a-novel-drug-resistant-candida-auris-with--peer-reviewed-fulltext-article-IDR |
| _version_ | 1797823839388827648 |
|---|---|
| author | Xu Z Zhang L Han R Ding C Shou H Duan X Zhang S |
| author_facet | Xu Z Zhang L Han R Ding C Shou H Duan X Zhang S |
| author_sort | Xu Z |
| collection | DOAJ |
| description | Zhaoxia Xu,1,* Lei Zhang,2,* Ran Han,1 Chengwei Ding,1 Haochang Shou,1 Xueguang Duan,1 Shengwei Zhang1 1Department of Clinical Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xueguang Duan; Shengwei Zhang, Department of Clinical Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China, Tel +86 13911179092 ; +86 13124780206, Email duanxg714@163.com; zswo6@aliyun.comBackground: Candida auris is a pathogen first found in external ear canal, becoming a major threat to global health. Here, we describe a candidemia case caused by a novel drug-resistant Candida auris strain.Case Presentation: An 80-year-old patient, with multiple serious medical conditions, was suffered from candidemia caused by Candida auris, died 9 days after admission in our hospital. Phylogenetic analysis indicates that this C. auris isolate (designated BJCA003) belongs to the South Asian clade, carries the Y132F mutation in the protein Erg11. And antibiotic susceptibility test indicated that BJCA003 is resistant to fluconazole and amphotericin B, not susceptible to caspofungin. In addition, this strain has multiple colony and cellular morphologies under different culture conditions.Conclusion: Strain BJCA003 is a novel drug resistant C. auris strain in mainland China, the Y132F mutation in Erg11 may attribute to fluconazole-resistance, alarming that we still face more challenges about C. auris.Keywords: Candida auris, candidemia, drug-resistant, mutation, morphologies |
| first_indexed | 2024-03-13T10:29:58Z |
| format | Article |
| id | doaj.art-689b5897e71841e58fd27b03b5f4c49d |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-13T10:29:58Z |
| publishDate | 2023-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-689b5897e71841e58fd27b03b5f4c49d2023-05-18T18:42:34ZengDove Medical PressInfection and Drug Resistance1178-69732023-05-01Volume 163065307283820A Candidemia Case Caused by a Novel Drug-Resistant Candida auris with the Y132F Mutation in Erg11 in Mainland ChinaXu ZZhang LHan RDing CShou HDuan XZhang SZhaoxia Xu,1,* Lei Zhang,2,* Ran Han,1 Chengwei Ding,1 Haochang Shou,1 Xueguang Duan,1 Shengwei Zhang1 1Department of Clinical Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xueguang Duan; Shengwei Zhang, Department of Clinical Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China, Tel +86 13911179092 ; +86 13124780206, Email duanxg714@163.com; zswo6@aliyun.comBackground: Candida auris is a pathogen first found in external ear canal, becoming a major threat to global health. Here, we describe a candidemia case caused by a novel drug-resistant Candida auris strain.Case Presentation: An 80-year-old patient, with multiple serious medical conditions, was suffered from candidemia caused by Candida auris, died 9 days after admission in our hospital. Phylogenetic analysis indicates that this C. auris isolate (designated BJCA003) belongs to the South Asian clade, carries the Y132F mutation in the protein Erg11. And antibiotic susceptibility test indicated that BJCA003 is resistant to fluconazole and amphotericin B, not susceptible to caspofungin. In addition, this strain has multiple colony and cellular morphologies under different culture conditions.Conclusion: Strain BJCA003 is a novel drug resistant C. auris strain in mainland China, the Y132F mutation in Erg11 may attribute to fluconazole-resistance, alarming that we still face more challenges about C. auris.Keywords: Candida auris, candidemia, drug-resistant, mutation, morphologieshttps://www.dovepress.com/a-candidemia-case-caused-by-a-novel-drug-resistant-candida-auris-with--peer-reviewed-fulltext-article-IDRcandida auriscandidemiadrug-resistantmutationmorphologies |
| spellingShingle | Xu Z Zhang L Han R Ding C Shou H Duan X Zhang S A Candidemia Case Caused by a Novel Drug-Resistant Candida auris with the Y132F Mutation in Erg11 in Mainland China Infection and Drug Resistance candida auris candidemia drug-resistant mutation morphologies |
| title | A Candidemia Case Caused by a Novel Drug-Resistant Candida auris with the Y132F Mutation in Erg11 in Mainland China |
| title_full | A Candidemia Case Caused by a Novel Drug-Resistant Candida auris with the Y132F Mutation in Erg11 in Mainland China |
| title_fullStr | A Candidemia Case Caused by a Novel Drug-Resistant Candida auris with the Y132F Mutation in Erg11 in Mainland China |
| title_full_unstemmed | A Candidemia Case Caused by a Novel Drug-Resistant Candida auris with the Y132F Mutation in Erg11 in Mainland China |
| title_short | A Candidemia Case Caused by a Novel Drug-Resistant Candida auris with the Y132F Mutation in Erg11 in Mainland China |
| title_sort | candidemia case caused by a novel drug resistant candida auris with the y132f mutation in erg11 in mainland china |
| topic | candida auris candidemia drug-resistant mutation morphologies |
| url | https://www.dovepress.com/a-candidemia-case-caused-by-a-novel-drug-resistant-candida-auris-with--peer-reviewed-fulltext-article-IDR |
| work_keys_str_mv | AT xuz acandidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT zhangl acandidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT hanr acandidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT dingc acandidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT shouh acandidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT duanx acandidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT zhangs acandidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT xuz candidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT zhangl candidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT hanr candidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT dingc candidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT shouh candidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT duanx candidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina AT zhangs candidemiacasecausedbyanoveldrugresistantcandidaauriswiththey132fmutationinerg11inmainlandchina |