Assessment of choroidal thickness and macular microvascular changes in amblyopic eyes using optical coherence tomography angiography
Aim This study aimed to assess microvascular and choroidal thickness (CT) changes in cases with unilateral amblyopia and to compare optical coherence tomography angiography parameters with the fellow eyes as well as with age-matched controls. Study design This is a prospective case–control study. Pa...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Delta Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.djo.eg.net/article.asp?issn=1110-9173;year=2020;volume=21;issue=4;spage=255;epage=260;aulast=Sadek |
| _version_ | 1819291424401653760 |
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| author | Sherin H Sadek Sherif A Eissa Ghada I Gawdat Ragai M Hatata |
| author_facet | Sherin H Sadek Sherif A Eissa Ghada I Gawdat Ragai M Hatata |
| author_sort | Sherin H Sadek |
| collection | DOAJ |
| description | Aim This study aimed to assess microvascular and choroidal thickness (CT) changes in cases with unilateral amblyopia and to compare optical coherence tomography angiography parameters with the fellow eyes as well as with age-matched controls.
Study design This is a prospective case–control study.
Patients and methods The study included 44 eyes; 12 eyes had unilateral anisometropic amblyopia compared with their fellow 12 eyes and 20 eyes from normal age-matched controls. Spectral-domain optical coherence tomography angiography was used to assess the vessel density (VD) of the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) in both 3×3 and 6×6 mm scans. In addition, central macular thickness, foveal avascular zone size, and CT were measured.
Results The mean age of amblyopic patients was 25.1±10.8 years with a mean BMI of 22.4±4.7 compared with the mean age of the control group (26.4±2.8 years) with a mean BMI of 21.0±2.1. Amblyopic eyes showed a statistically nonsignificant decrease in subfoveal CT (mean=328.58±34.46 μm) and temporal CT (mean=318.42±33.93 μm) compared with their fellow eyes (321.00±42.41 and 317.33±57.21 μm, respectively) and with the control eyes (subfoveal CT 349.80±72.33 μm and temporal CT 346.50±40.61 μm, P=0.178 and 0.177, respectively). There was a significantly decreased VD in the SCP of amblyopic eyes at the 3 mm scan (P=0.032) with a mean of 43.87±4.67% in the whole image. In addition, DCP VD in the 6 mm scan showed a statistically significant decrease (mean=43.91±7.26%) compared with the fellow and control eyes (P=0.001). The foveal avascular zone size was almost the same in all groups (0.28±0.13 mm2) with no significant difference.
Conclusion Amblyopic eyes showed decreased VD in both SCP and DCP compared with that of the fellow eyes and controls. |
| first_indexed | 2024-12-24T03:38:25Z |
| format | Article |
| id | doaj.art-689c8ed05fb04db990103bb46aa2c8b1 |
| institution | Directory Open Access Journal |
| issn | 1110-9173 2090-4835 |
| language | English |
| last_indexed | 2024-12-24T03:38:25Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delta Journal of Ophthalmology |
| spelling | doaj.art-689c8ed05fb04db990103bb46aa2c8b12022-12-21T17:17:00ZengWolters Kluwer Medknow PublicationsDelta Journal of Ophthalmology1110-91732090-48352020-01-0121425526010.4103/DJO.DJO_34_20Assessment of choroidal thickness and macular microvascular changes in amblyopic eyes using optical coherence tomography angiographySherin H SadekSherif A EissaGhada I GawdatRagai M HatataAim This study aimed to assess microvascular and choroidal thickness (CT) changes in cases with unilateral amblyopia and to compare optical coherence tomography angiography parameters with the fellow eyes as well as with age-matched controls. Study design This is a prospective case–control study. Patients and methods The study included 44 eyes; 12 eyes had unilateral anisometropic amblyopia compared with their fellow 12 eyes and 20 eyes from normal age-matched controls. Spectral-domain optical coherence tomography angiography was used to assess the vessel density (VD) of the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) in both 3×3 and 6×6 mm scans. In addition, central macular thickness, foveal avascular zone size, and CT were measured. Results The mean age of amblyopic patients was 25.1±10.8 years with a mean BMI of 22.4±4.7 compared with the mean age of the control group (26.4±2.8 years) with a mean BMI of 21.0±2.1. Amblyopic eyes showed a statistically nonsignificant decrease in subfoveal CT (mean=328.58±34.46 μm) and temporal CT (mean=318.42±33.93 μm) compared with their fellow eyes (321.00±42.41 and 317.33±57.21 μm, respectively) and with the control eyes (subfoveal CT 349.80±72.33 μm and temporal CT 346.50±40.61 μm, P=0.178 and 0.177, respectively). There was a significantly decreased VD in the SCP of amblyopic eyes at the 3 mm scan (P=0.032) with a mean of 43.87±4.67% in the whole image. In addition, DCP VD in the 6 mm scan showed a statistically significant decrease (mean=43.91±7.26%) compared with the fellow and control eyes (P=0.001). The foveal avascular zone size was almost the same in all groups (0.28±0.13 mm2) with no significant difference. Conclusion Amblyopic eyes showed decreased VD in both SCP and DCP compared with that of the fellow eyes and controls.http://www.djo.eg.net/article.asp?issn=1110-9173;year=2020;volume=21;issue=4;spage=255;epage=260;aulast=Sadekamblyopiachoroidal thicknessmacular microvascularoptical coherence tomography angiography |
| spellingShingle | Sherin H Sadek Sherif A Eissa Ghada I Gawdat Ragai M Hatata Assessment of choroidal thickness and macular microvascular changes in amblyopic eyes using optical coherence tomography angiography Delta Journal of Ophthalmology amblyopia choroidal thickness macular microvascular optical coherence tomography angiography |
| title | Assessment of choroidal thickness and macular microvascular changes in amblyopic eyes using optical coherence tomography angiography |
| title_full | Assessment of choroidal thickness and macular microvascular changes in amblyopic eyes using optical coherence tomography angiography |
| title_fullStr | Assessment of choroidal thickness and macular microvascular changes in amblyopic eyes using optical coherence tomography angiography |
| title_full_unstemmed | Assessment of choroidal thickness and macular microvascular changes in amblyopic eyes using optical coherence tomography angiography |
| title_short | Assessment of choroidal thickness and macular microvascular changes in amblyopic eyes using optical coherence tomography angiography |
| title_sort | assessment of choroidal thickness and macular microvascular changes in amblyopic eyes using optical coherence tomography angiography |
| topic | amblyopia choroidal thickness macular microvascular optical coherence tomography angiography |
| url | http://www.djo.eg.net/article.asp?issn=1110-9173;year=2020;volume=21;issue=4;spage=255;epage=260;aulast=Sadek |
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