Predictive factors for early response to methimazole in children and adolescents with Graves disease: a single-institute study between 1993 and 2013
PurposeWe aimed to investigate the predictive factors for early response to methimazole (MMI) in pediatric patients with Graves disease (GD).MethodsOur study included 44 pediatric patients who were diagnosed with GD between January 1, 1993, and December 31, 2013, and were available for follow-up, ac...
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| Format: | Article |
| Language: | English |
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Korean Society of Pediatric Endocrinology
2016-06-01
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| Series: | Annals of Pediatric Endocrinology & Metabolism |
| Subjects: | |
| Online Access: | http://e-apem.org/upload/pdf/apem-21-70.pdf |
| _version_ | 1818691545363120128 |
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| author | Sun Mi Hwang Min Sun Kim Dae-Yeol Lee |
| author_facet | Sun Mi Hwang Min Sun Kim Dae-Yeol Lee |
| author_sort | Sun Mi Hwang |
| collection | DOAJ |
| description | PurposeWe aimed to investigate the predictive factors for early response to methimazole (MMI) in pediatric patients with Graves disease (GD).MethodsOur study included 44 pediatric patients who were diagnosed with GD between January 1, 1993, and December 31, 2013, and were available for follow-up, achieving a normalization of thyroid functions (TFs) at the Chonbuk National University Hospital Pediatric Department. We retrospectively analyzed TFs such as tri-iodothyronine (T3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), and thyroid antibody levels at diagnosis. We also examined their family history of thyroid disease, symptoms at presentation, and normalization time for TF after treatment. We divided our clinical series of patients into the following 4 age groups: <7 years old, 7–12 years old, 13–15 years old, and 16–18 years old.ResultsAt diagnosis, the time of normalization of T3 was significantly shorter in the higher antimicrosomal antibody (AMA) group compared with the lower AMA group (2.53 months vs. 6.18 months) (P<0.05). However, the time of normalization of T3/fT4/TSH had no significant correlations with other variables such as age, sex, a family history of thyroid diseases, thyroglobulin, thyroid-stimulating immunoglobulin, or antithyroglobulin antibody (ATA).ConclusionHigher serological titers of AMA at diagnosis may have prognostic value in the response to initial MMI treatment in pediatric hyperthyroid GD patients. |
| first_indexed | 2024-12-17T12:43:36Z |
| format | Article |
| id | doaj.art-689e8ca34d35486e83b06cc65c402982 |
| institution | Directory Open Access Journal |
| issn | 2287-1012 2287-1292 |
| language | English |
| last_indexed | 2024-12-17T12:43:36Z |
| publishDate | 2016-06-01 |
| publisher | Korean Society of Pediatric Endocrinology |
| record_format | Article |
| series | Annals of Pediatric Endocrinology & Metabolism |
| spelling | doaj.art-689e8ca34d35486e83b06cc65c4029822022-12-21T21:47:50ZengKorean Society of Pediatric EndocrinologyAnnals of Pediatric Endocrinology & Metabolism2287-10122287-12922016-06-01212707410.6065/apem.2016.21.2.70649Predictive factors for early response to methimazole in children and adolescents with Graves disease: a single-institute study between 1993 and 2013Sun Mi Hwang0Min Sun Kim1Dae-Yeol Lee2Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.PurposeWe aimed to investigate the predictive factors for early response to methimazole (MMI) in pediatric patients with Graves disease (GD).MethodsOur study included 44 pediatric patients who were diagnosed with GD between January 1, 1993, and December 31, 2013, and were available for follow-up, achieving a normalization of thyroid functions (TFs) at the Chonbuk National University Hospital Pediatric Department. We retrospectively analyzed TFs such as tri-iodothyronine (T3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), and thyroid antibody levels at diagnosis. We also examined their family history of thyroid disease, symptoms at presentation, and normalization time for TF after treatment. We divided our clinical series of patients into the following 4 age groups: <7 years old, 7–12 years old, 13–15 years old, and 16–18 years old.ResultsAt diagnosis, the time of normalization of T3 was significantly shorter in the higher antimicrosomal antibody (AMA) group compared with the lower AMA group (2.53 months vs. 6.18 months) (P<0.05). However, the time of normalization of T3/fT4/TSH had no significant correlations with other variables such as age, sex, a family history of thyroid diseases, thyroglobulin, thyroid-stimulating immunoglobulin, or antithyroglobulin antibody (ATA).ConclusionHigher serological titers of AMA at diagnosis may have prognostic value in the response to initial MMI treatment in pediatric hyperthyroid GD patients.http://e-apem.org/upload/pdf/apem-21-70.pdfGraves diseaseTriiodothyronineAdolescentMethimazolethyroid microsomal antibodies |
| spellingShingle | Sun Mi Hwang Min Sun Kim Dae-Yeol Lee Predictive factors for early response to methimazole in children and adolescents with Graves disease: a single-institute study between 1993 and 2013 Annals of Pediatric Endocrinology & Metabolism Graves disease Triiodothyronine Adolescent Methimazole thyroid microsomal antibodies |
| title | Predictive factors for early response to methimazole in children and adolescents with Graves disease: a single-institute study between 1993 and 2013 |
| title_full | Predictive factors for early response to methimazole in children and adolescents with Graves disease: a single-institute study between 1993 and 2013 |
| title_fullStr | Predictive factors for early response to methimazole in children and adolescents with Graves disease: a single-institute study between 1993 and 2013 |
| title_full_unstemmed | Predictive factors for early response to methimazole in children and adolescents with Graves disease: a single-institute study between 1993 and 2013 |
| title_short | Predictive factors for early response to methimazole in children and adolescents with Graves disease: a single-institute study between 1993 and 2013 |
| title_sort | predictive factors for early response to methimazole in children and adolescents with graves disease a single institute study between 1993 and 2013 |
| topic | Graves disease Triiodothyronine Adolescent Methimazole thyroid microsomal antibodies |
| url | http://e-apem.org/upload/pdf/apem-21-70.pdf |
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