Retinal Microvascular Reactivity in Chronic Cigarette Smokers and Non-smokers: An Observational Cross-Sectional Study
Purpose: To evaluate the changes in the retinal microvasculature and its reactivity in chronic cigarette smokers.Methods: Thirty-four male chronic cigarette smokers and 18 male non-smokers were enrolled. Optical coherence tomography angiography was used to measure the perfused retinal vessel densiti...
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.782010/full |
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| author | Huan Xu Huan Xu Yuan Zong Yuan Zong Jian Yu Jian Yu Chunhui Jiang Chunhui Jiang Haohao Zhu Xinghuai Sun Xinghuai Sun |
| author_facet | Huan Xu Huan Xu Yuan Zong Yuan Zong Jian Yu Jian Yu Chunhui Jiang Chunhui Jiang Haohao Zhu Xinghuai Sun Xinghuai Sun |
| author_sort | Huan Xu |
| collection | DOAJ |
| description | Purpose: To evaluate the changes in the retinal microvasculature and its reactivity in chronic cigarette smokers.Methods: Thirty-four male chronic cigarette smokers and 18 male non-smokers were enrolled. Optical coherence tomography angiography was used to measure the perfused retinal vessel densities (PVDs) of the peripapillary and parafoveal areas at baseline and during phase IV of the Valsalva maneuver (VM-IV). Systemic blood pressure and intraocular pressure were also measured.Results: The baseline PVD in the peripapillary area of the smokers was significantly lower than the non-smokers (59.56 ± 2.26% vs. 61.67 ± 3.58%, respectively; P = 0.005). However, there was no significant difference in the foveal avascular zone or parafoveal PVD between the two groups. During VM-IV, the peripapillary PVD of the smokers decreased by 1.13 ± 3.50%, which was significantly less than that of the non-smokers (−3.83 ± 4.26%, P < 0.05). Similarly, the parafoveal PVD of the smokers decreased by 5.49 ± 9.70%, which was significantly less than the percentage change of the non-smokers (−13.01 ± 8.39%, P < 0.05). There was no significant difference in the percentage change in systemic blood pressure parameters between the two groups.Conclusion: The retinal microvasculature and its reactivity were impaired in chronic smokers compared with non-smokers. The extent of impairment differed among different regions of the fundus. |
| first_indexed | 2024-12-22T21:36:05Z |
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| language | English |
| last_indexed | 2024-12-22T21:36:05Z |
| publishDate | 2021-12-01 |
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| series | Frontiers in Medicine |
| spelling | doaj.art-689ffa2e205540769541947b5dbc06fd2022-12-21T18:11:46ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-12-01810.3389/fmed.2021.782010782010Retinal Microvascular Reactivity in Chronic Cigarette Smokers and Non-smokers: An Observational Cross-Sectional StudyHuan Xu0Huan Xu1Yuan Zong2Yuan Zong3Jian Yu4Jian Yu5Chunhui Jiang6Chunhui Jiang7Haohao Zhu8Xinghuai Sun9Xinghuai Sun10Department of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College of Fudan University, Shanghai, ChinaKey Laboratory of Myopia of State Health Ministry and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, ChinaDepartment of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College of Fudan University, Shanghai, ChinaKey Laboratory of Myopia of State Health Ministry and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, ChinaDepartment of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College of Fudan University, Shanghai, ChinaKey Laboratory of Myopia of State Health Ministry and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, ChinaDepartment of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College of Fudan University, Shanghai, ChinaKey Laboratory of Myopia of State Health Ministry and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology and Visual Science, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College of Fudan University, Shanghai, ChinaKey Laboratory of Myopia of State Health Ministry and Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, ChinaPurpose: To evaluate the changes in the retinal microvasculature and its reactivity in chronic cigarette smokers.Methods: Thirty-four male chronic cigarette smokers and 18 male non-smokers were enrolled. Optical coherence tomography angiography was used to measure the perfused retinal vessel densities (PVDs) of the peripapillary and parafoveal areas at baseline and during phase IV of the Valsalva maneuver (VM-IV). Systemic blood pressure and intraocular pressure were also measured.Results: The baseline PVD in the peripapillary area of the smokers was significantly lower than the non-smokers (59.56 ± 2.26% vs. 61.67 ± 3.58%, respectively; P = 0.005). However, there was no significant difference in the foveal avascular zone or parafoveal PVD between the two groups. During VM-IV, the peripapillary PVD of the smokers decreased by 1.13 ± 3.50%, which was significantly less than that of the non-smokers (−3.83 ± 4.26%, P < 0.05). Similarly, the parafoveal PVD of the smokers decreased by 5.49 ± 9.70%, which was significantly less than the percentage change of the non-smokers (−13.01 ± 8.39%, P < 0.05). There was no significant difference in the percentage change in systemic blood pressure parameters between the two groups.Conclusion: The retinal microvasculature and its reactivity were impaired in chronic smokers compared with non-smokers. The extent of impairment differed among different regions of the fundus.https://www.frontiersin.org/articles/10.3389/fmed.2021.782010/fullretinal microvasculaturereactivityoptical coherence tomography angiography (OCTA)blood pressureValsalva maneuver (VM) |
| spellingShingle | Huan Xu Huan Xu Yuan Zong Yuan Zong Jian Yu Jian Yu Chunhui Jiang Chunhui Jiang Haohao Zhu Xinghuai Sun Xinghuai Sun Retinal Microvascular Reactivity in Chronic Cigarette Smokers and Non-smokers: An Observational Cross-Sectional Study Frontiers in Medicine retinal microvasculature reactivity optical coherence tomography angiography (OCTA) blood pressure Valsalva maneuver (VM) |
| title | Retinal Microvascular Reactivity in Chronic Cigarette Smokers and Non-smokers: An Observational Cross-Sectional Study |
| title_full | Retinal Microvascular Reactivity in Chronic Cigarette Smokers and Non-smokers: An Observational Cross-Sectional Study |
| title_fullStr | Retinal Microvascular Reactivity in Chronic Cigarette Smokers and Non-smokers: An Observational Cross-Sectional Study |
| title_full_unstemmed | Retinal Microvascular Reactivity in Chronic Cigarette Smokers and Non-smokers: An Observational Cross-Sectional Study |
| title_short | Retinal Microvascular Reactivity in Chronic Cigarette Smokers and Non-smokers: An Observational Cross-Sectional Study |
| title_sort | retinal microvascular reactivity in chronic cigarette smokers and non smokers an observational cross sectional study |
| topic | retinal microvasculature reactivity optical coherence tomography angiography (OCTA) blood pressure Valsalva maneuver (VM) |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.782010/full |
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