Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats
Abstract In this study, the potential neuroprotective ability of coriander seeds (Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how CSES impacts oxidative stress markers (i.e., malondi...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-51221-5 |
| _version_ | 1797363370658103296 |
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| author | Novi Silvia Hardiany Putri Krishna Kumara Dewi Syarifah Dewi Bimo A. Tejo |
| author_facet | Novi Silvia Hardiany Putri Krishna Kumara Dewi Syarifah Dewi Bimo A. Tejo |
| author_sort | Novi Silvia Hardiany |
| collection | DOAJ |
| description | Abstract In this study, the potential neuroprotective ability of coriander seeds (Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how CSES impacts oxidative stress markers (i.e., malondialdehyde/MDA, glutathione/GSH and catalase), inflammation marker (i.e., Interleukin-6/IL-6), cellular senescence markers (i.e., senescence-associated β-galactoside/SA-β-Gal activity and p16), brain damage marker (i.e., Neuron-specific Enolase/NSE), and neurogenesis markers (i.e., mature Brain-derived Neurotropic Factor/BDNF, pro-BDNF, and mature/pro-BDNF ratio). Male adult Wistar rats were fed a high-fat diet and given CSES once daily, at 100 mg/kg body weight, for 12 weeks. CSES significantly reduced MDA concentration (p = < 0.001), SA-β-Gal activity (p = 0.010), and increased GSH concentration (p = 0.047) in the brain of obese rats; however, the decrease of IL-6, NSE, and p16 as well as the increase of catalase specific activity and BDNF expression were not significant. Moreover, the mature/pro-BDNF ratio was significantly higher in the brains of non-obese rats, both given the control diet and the high-fat diet compared to the control. Our results suggest that obese rats benefited from consuming CSES, showing improved oxidative stress levels, reduced cellular senescence and increased endogenous antioxidants, making CSES a potential neuroprotective agent. |
| first_indexed | 2024-03-08T16:19:24Z |
| format | Article |
| id | doaj.art-68a04c412b0e4764a76ca80a076708b4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T16:19:24Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-68a04c412b0e4764a76ca80a076708b42024-01-07T12:25:24ZengNature PortfolioScientific Reports2045-23222024-01-0114111010.1038/s41598-024-51221-5Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese ratsNovi Silvia Hardiany0Putri Krishna Kumara Dewi1Syarifah Dewi2Bimo A. Tejo3Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas IndonesiaMaster Program in Biomedical Sciences, Faculty of Medicine, Universitas IndonesiaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas IndonesiaDepartment of Chemistry, Faculty of Science, Universiti Putra MalaysiaAbstract In this study, the potential neuroprotective ability of coriander seeds (Coriandrum sativum L.) ethanolic extract (CSES) as a neuroprotectant agent in the brains of high-fat diet-induced obese rats was analyzed. The study investigated how CSES impacts oxidative stress markers (i.e., malondialdehyde/MDA, glutathione/GSH and catalase), inflammation marker (i.e., Interleukin-6/IL-6), cellular senescence markers (i.e., senescence-associated β-galactoside/SA-β-Gal activity and p16), brain damage marker (i.e., Neuron-specific Enolase/NSE), and neurogenesis markers (i.e., mature Brain-derived Neurotropic Factor/BDNF, pro-BDNF, and mature/pro-BDNF ratio). Male adult Wistar rats were fed a high-fat diet and given CSES once daily, at 100 mg/kg body weight, for 12 weeks. CSES significantly reduced MDA concentration (p = < 0.001), SA-β-Gal activity (p = 0.010), and increased GSH concentration (p = 0.047) in the brain of obese rats; however, the decrease of IL-6, NSE, and p16 as well as the increase of catalase specific activity and BDNF expression were not significant. Moreover, the mature/pro-BDNF ratio was significantly higher in the brains of non-obese rats, both given the control diet and the high-fat diet compared to the control. Our results suggest that obese rats benefited from consuming CSES, showing improved oxidative stress levels, reduced cellular senescence and increased endogenous antioxidants, making CSES a potential neuroprotective agent.https://doi.org/10.1038/s41598-024-51221-5 |
| spellingShingle | Novi Silvia Hardiany Putri Krishna Kumara Dewi Syarifah Dewi Bimo A. Tejo Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats Scientific Reports |
| title | Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats |
| title_full | Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats |
| title_fullStr | Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats |
| title_full_unstemmed | Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats |
| title_short | Exploration of neuroprotective effect from Coriandrum sativum L. ethanolic seeds extracts on brain of obese rats |
| title_sort | exploration of neuroprotective effect from coriandrum sativum l ethanolic seeds extracts on brain of obese rats |
| url | https://doi.org/10.1038/s41598-024-51221-5 |
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