The effects of low-dose IL-2 on Th17/Treg cell imbalance in primary biliary cholangitis mouse models

The effects of low-dose IL-2 on Th17/Treg cell imbalance in primary biliary cholangitis mouse models

Abstract Background/aims Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease. The imbalance of Th17/Treg cells has been reported in PBC patients. Low-dose IL-2 can alleviate disease severity through modulating CD4 + T cell subsets in patients with autoimmune diseases. Hence, the...

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Bibliographic Details
Main Authors: Zilong Wang, Zhicheng Liu, Jiarui Zheng, Linxiang Huang, Rui Jin, Xiaoxiao Wang, Dongbo Chen, Yandi Xie, Bo Feng
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Gastroenterology
Subjects:
Primary biliary cholangitis
Interleukin 2
Treg cells
Th17 cells
Mouse model
Online Access:https://doi.org/10.1186/s12876-024-03176-0

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