Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancer
Background: The most important part of the follow-up of differentiated thyroid carcinoma (DTC) is the measurement of serum thyroglobulin (Tg). An increase of Tg levels indicates likely tumor recurrence. According to the guidelines of the European Society of Medical Oncology (ESMO), the follow-up sho...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2024-04-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/13/5/EC-24-0007.xml |
| _version_ | 1827284709023940608 |
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| author | Teresa Kraus Natalia Shengelia-de Lange Holger Einspieler Marcus Hacker Alexander Haug Elisabeth Kretschmer-Chott Georgios Karanikas |
| author_facet | Teresa Kraus Natalia Shengelia-de Lange Holger Einspieler Marcus Hacker Alexander Haug Elisabeth Kretschmer-Chott Georgios Karanikas |
| author_sort | Teresa Kraus |
| collection | DOAJ |
| description | Background: The most important part of the follow-up of differentiated thyroid carcinoma (DTC) is the measurement of serum thyroglobulin (Tg). An increase of Tg levels indicates likely tumor recurrence. According to the guidelines of the European Society of Medical Oncology (ESMO), the follow-up should consist of serum Tg assays and a neck ultrasound, while the American Thyroid Association (ATA) recommends serum Tg assays, neck ultrasounds, and a diagnostic radioiodine whole-body scan (WBS) if non-stimulated Tg is greater than 10 ng/mL or if Tg is rising. This study questions the necessity of a diagnostic WBS in patients with low stimulated Tg levels during the initial follow-up.
Design: This study is a retrospective data analysis.
Methods: The data of 185 patients, who were in regular treatment and aftercare between 2015 and 2018 at the Department of Nuclear Medicine in Vienna, as well as the data of 185 patients who were treated in Tbilisi between 2015 and 2019, were analyzed.
Results: There was a highly significant relationship between low stimulated Tg levels (<0.5 ng/mL) and the outcome of the diagnostic WBS at the first follow-up (χ2 = 14.7, P < 0.001). In total, 31 out of 370 patients (8.4%) had positive findings in the diagnostic WBS. Seventy-five of 370 patients (19.74%) had stimulated Tg levels >0.5 ng/mL.
Conclusion: Our data suggest that the first follow-up, 4–12 months after the initial therapy of DTC, including the measurement of basal and stimulated Tg levels and Tg antibody levels, does not mandate a diagnostic WBS on all patients. |
| first_indexed | 2024-04-24T10:02:01Z |
| format | Article |
| id | doaj.art-68a2298088f641c7b497396fa91d9890 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 |
| language | English |
| last_indexed | 2024-04-24T10:02:01Z |
| publishDate | 2024-04-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-68a2298088f641c7b497396fa91d98902024-04-13T09:33:38ZengBioscientificaEndocrine Connections2049-36142024-04-0113516https://doi.org/10.1530/EC-24-0007Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancerTeresa Kraus0Natalia Shengelia-de Lange1Holger Einspieler2Marcus Hacker3Alexander Haug4Elisabeth Kretschmer-Chott5Georgios Karanikas6Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaDivision of Nuclear Medicine, Tbilisi State Medical University, Tbilisi, GeorgiaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, AustriaBackground: The most important part of the follow-up of differentiated thyroid carcinoma (DTC) is the measurement of serum thyroglobulin (Tg). An increase of Tg levels indicates likely tumor recurrence. According to the guidelines of the European Society of Medical Oncology (ESMO), the follow-up should consist of serum Tg assays and a neck ultrasound, while the American Thyroid Association (ATA) recommends serum Tg assays, neck ultrasounds, and a diagnostic radioiodine whole-body scan (WBS) if non-stimulated Tg is greater than 10 ng/mL or if Tg is rising. This study questions the necessity of a diagnostic WBS in patients with low stimulated Tg levels during the initial follow-up. Design: This study is a retrospective data analysis. Methods: The data of 185 patients, who were in regular treatment and aftercare between 2015 and 2018 at the Department of Nuclear Medicine in Vienna, as well as the data of 185 patients who were treated in Tbilisi between 2015 and 2019, were analyzed. Results: There was a highly significant relationship between low stimulated Tg levels (<0.5 ng/mL) and the outcome of the diagnostic WBS at the first follow-up (χ2 = 14.7, P < 0.001). In total, 31 out of 370 patients (8.4%) had positive findings in the diagnostic WBS. Seventy-five of 370 patients (19.74%) had stimulated Tg levels >0.5 ng/mL. Conclusion: Our data suggest that the first follow-up, 4–12 months after the initial therapy of DTC, including the measurement of basal and stimulated Tg levels and Tg antibody levels, does not mandate a diagnostic WBS on all patients.https://ec.bioscientifica.com/view/journals/ec/13/5/EC-24-0007.xmlthyroid cancethyroglobulinfollow-updiagnostic radioiodine whole-body scan |
| spellingShingle | Teresa Kraus Natalia Shengelia-de Lange Holger Einspieler Marcus Hacker Alexander Haug Elisabeth Kretschmer-Chott Georgios Karanikas Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancer Endocrine Connections thyroid cance thyroglobulin follow-up diagnostic radioiodine whole-body scan |
| title | Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancer |
| title_full | Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancer |
| title_fullStr | Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancer |
| title_full_unstemmed | Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancer |
| title_short | Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancer |
| title_sort | value of follow up diagnostic radioiodine scans in differentiated thyroid cancer |
| topic | thyroid cance thyroglobulin follow-up diagnostic radioiodine whole-body scan |
| url | https://ec.bioscientifica.com/view/journals/ec/13/5/EC-24-0007.xml |
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