Recent advances in nanomaterials for the treatment of spinal cord injury
Spinal cord injuries (SCIs) are devastating. In SCIs, a powerful traumatic force impacting the spinal cord results in the permanent loss of nerve function below the injury level, leaving the patient paralyzed and wheelchair-bound for the remainder of his/her life. Unfortunately, clinical treatment t...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422003222 |
| _version_ | 1828048258261319680 |
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| author | Weiquan Gong Tianhui Zhang Mingxue Che Yongjie Wang Chuanyu He Lidi Liu Zhenshan Lv Chunsheng Xiao Hao Wang Shaokun Zhang |
| author_facet | Weiquan Gong Tianhui Zhang Mingxue Che Yongjie Wang Chuanyu He Lidi Liu Zhenshan Lv Chunsheng Xiao Hao Wang Shaokun Zhang |
| author_sort | Weiquan Gong |
| collection | DOAJ |
| description | Spinal cord injuries (SCIs) are devastating. In SCIs, a powerful traumatic force impacting the spinal cord results in the permanent loss of nerve function below the injury level, leaving the patient paralyzed and wheelchair-bound for the remainder of his/her life. Unfortunately, clinical treatment that depends on surgical decompression appears to be unable to handle damaged nerves, and high-dose methylprednisolone-based therapy is also associated with problems, such as infection, gastrointestinal bleeding, femoral head necrosis, obesity, and hyperglycemia. Nanomaterials have opened new avenues for SCI treatment. Among them, performance-based nanomaterials derived from a variety of materials facilitate improvements in the microenvironment of traumatic injury and, in some cases, promote neuron regeneration. Nanoparticulate drug delivery systems enable the optimization of drug effects and drug bioavailability, thus contributing to the development of novel treatments. The improved efficiency and accuracy of gene delivery will also benefit the exploration of SCI mechanisms and the understanding of key genes and signaling pathways. Herein, we reviewed different types of nanomaterials applied to the treatment of SCI and summarized their functions and advantages to provide new perspectives for future clinical therapies. |
| first_indexed | 2024-04-10T18:54:41Z |
| format | Article |
| id | doaj.art-68a2b677978042a6a545d7c0640c4196 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-10T18:54:41Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-68a2b677978042a6a545d7c0640c41962023-02-01T04:27:22ZengElsevierMaterials Today Bio2590-00642023-02-0118100524Recent advances in nanomaterials for the treatment of spinal cord injuryWeiquan Gong0Tianhui Zhang1Mingxue Che2Yongjie Wang3Chuanyu He4Lidi Liu5Zhenshan Lv6Chunsheng Xiao7Hao Wang8Shaokun Zhang9Department of Spine Surgery, Orthopedics Center, First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Jilin Engineering Research Center for Spine and Spinal Cord Injury, ChinaDepartment of Spine Surgery, Orthopedics Center, First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, China; Jilin Engineering Research Center for Spine and Spinal Cord Injury, ChinaDepartment of Spine Surgery, Orthopedics Center, First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, China; Jilin Engineering Research Center for Spine and Spinal Cord Injury, ChinaDepartment of Spine Surgery, Orthopedics Center, First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, China; Jilin Engineering Research Center for Spine and Spinal Cord Injury, ChinaDepartment of Spine Surgery, Orthopedics Center, First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, China; Jilin Engineering Research Center for Spine and Spinal Cord Injury, ChinaDepartment of Spine Surgery, Orthopedics Center, First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, China; Jilin Engineering Research Center for Spine and Spinal Cord Injury, ChinaDepartment of Spine Surgery, Orthopedics Center, First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, China; Jilin Engineering Research Center for Spine and Spinal Cord Injury, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, ChinaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China; Corresponding author.Department of Spine Surgery, Orthopedics Center, First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, China; Jilin Engineering Research Center for Spine and Spinal Cord Injury, China; Corresponding author. Department of Spine Surgery, Orthopedics Center, First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130021, China.Spinal cord injuries (SCIs) are devastating. In SCIs, a powerful traumatic force impacting the spinal cord results in the permanent loss of nerve function below the injury level, leaving the patient paralyzed and wheelchair-bound for the remainder of his/her life. Unfortunately, clinical treatment that depends on surgical decompression appears to be unable to handle damaged nerves, and high-dose methylprednisolone-based therapy is also associated with problems, such as infection, gastrointestinal bleeding, femoral head necrosis, obesity, and hyperglycemia. Nanomaterials have opened new avenues for SCI treatment. Among them, performance-based nanomaterials derived from a variety of materials facilitate improvements in the microenvironment of traumatic injury and, in some cases, promote neuron regeneration. Nanoparticulate drug delivery systems enable the optimization of drug effects and drug bioavailability, thus contributing to the development of novel treatments. The improved efficiency and accuracy of gene delivery will also benefit the exploration of SCI mechanisms and the understanding of key genes and signaling pathways. Herein, we reviewed different types of nanomaterials applied to the treatment of SCI and summarized their functions and advantages to provide new perspectives for future clinical therapies.http://www.sciencedirect.com/science/article/pii/S2590006422003222Spinal cord injuryInorganic nanomaterialOrganic nanomaterialBioderived nanomaterialNeuroprotectionNeuroregeneration |
| spellingShingle | Weiquan Gong Tianhui Zhang Mingxue Che Yongjie Wang Chuanyu He Lidi Liu Zhenshan Lv Chunsheng Xiao Hao Wang Shaokun Zhang Recent advances in nanomaterials for the treatment of spinal cord injury Materials Today Bio Spinal cord injury Inorganic nanomaterial Organic nanomaterial Bioderived nanomaterial Neuroprotection Neuroregeneration |
| title | Recent advances in nanomaterials for the treatment of spinal cord injury |
| title_full | Recent advances in nanomaterials for the treatment of spinal cord injury |
| title_fullStr | Recent advances in nanomaterials for the treatment of spinal cord injury |
| title_full_unstemmed | Recent advances in nanomaterials for the treatment of spinal cord injury |
| title_short | Recent advances in nanomaterials for the treatment of spinal cord injury |
| title_sort | recent advances in nanomaterials for the treatment of spinal cord injury |
| topic | Spinal cord injury Inorganic nanomaterial Organic nanomaterial Bioderived nanomaterial Neuroprotection Neuroregeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422003222 |
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