Current advances on the therapeutic potential of pinocembrin: An updated review
Pinocembrin (5,7-dihydroxyflavone) is a major flavonoid found in many plants, fungi and hive products, mainly honey and propolis. Several in vitro and preclinical studies revealed numerous pharmacological activities of pinocembrin including antioxidant, anti-inflammatory, antimicrobial, neuroprotect...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222014214 |
| _version_ | 1811187710112563200 |
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| author | Mahmoud H. Elbatreek Ismail Mahdi Wafae Ouchari Mona F. Mahmoud Mansour Sobeh |
| author_facet | Mahmoud H. Elbatreek Ismail Mahdi Wafae Ouchari Mona F. Mahmoud Mansour Sobeh |
| author_sort | Mahmoud H. Elbatreek |
| collection | DOAJ |
| description | Pinocembrin (5,7-dihydroxyflavone) is a major flavonoid found in many plants, fungi and hive products, mainly honey and propolis. Several in vitro and preclinical studies revealed numerous pharmacological activities of pinocembrin including antioxidant, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective and anticancer activities. Here, we comprehensively review and critically analyze the studies carried out on pinocembrin. We also discuss its potential mechanisms of action, bioavailability, toxicity, and clinical investigations. The wide therapeutic window of pinocembrin makes it a promising drug candidate for many clinical applications. We recommend some future perspectives to improve its pharmacokinetic and pharmacodynamic properties for better delivery that may also lead to new therapeutic advances. |
| first_indexed | 2024-04-11T14:08:04Z |
| format | Article |
| id | doaj.art-68a34b4a0fdd432cb0aa50ffa5ad20a5 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T14:08:04Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-68a34b4a0fdd432cb0aa50ffa5ad20a52022-12-22T04:19:49ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-01-01157114032Current advances on the therapeutic potential of pinocembrin: An updated reviewMahmoud H. Elbatreek0Ismail Mahdi1Wafae Ouchari2Mona F. Mahmoud3Mansour Sobeh4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, EgyptAgrobiosciences, Mohamed IV Polytechnic University, Lot 660, Hay Moulay Rachid, Ben-Guerir 43150, MoroccoAgrobiosciences, Mohamed IV Polytechnic University, Lot 660, Hay Moulay Rachid, Ben-Guerir 43150, MoroccoDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt; Corresponding authors.Agrobiosciences, Mohamed IV Polytechnic University, Lot 660, Hay Moulay Rachid, Ben-Guerir 43150, Morocco; Corresponding authors.Pinocembrin (5,7-dihydroxyflavone) is a major flavonoid found in many plants, fungi and hive products, mainly honey and propolis. Several in vitro and preclinical studies revealed numerous pharmacological activities of pinocembrin including antioxidant, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective and anticancer activities. Here, we comprehensively review and critically analyze the studies carried out on pinocembrin. We also discuss its potential mechanisms of action, bioavailability, toxicity, and clinical investigations. The wide therapeutic window of pinocembrin makes it a promising drug candidate for many clinical applications. We recommend some future perspectives to improve its pharmacokinetic and pharmacodynamic properties for better delivery that may also lead to new therapeutic advances.http://www.sciencedirect.com/science/article/pii/S0753332222014214PinocembrinBiosynthesisPharmacological activitiesPharmacokineticsGut microbiotaClinical trials |
| spellingShingle | Mahmoud H. Elbatreek Ismail Mahdi Wafae Ouchari Mona F. Mahmoud Mansour Sobeh Current advances on the therapeutic potential of pinocembrin: An updated review Biomedicine & Pharmacotherapy Pinocembrin Biosynthesis Pharmacological activities Pharmacokinetics Gut microbiota Clinical trials |
| title | Current advances on the therapeutic potential of pinocembrin: An updated review |
| title_full | Current advances on the therapeutic potential of pinocembrin: An updated review |
| title_fullStr | Current advances on the therapeutic potential of pinocembrin: An updated review |
| title_full_unstemmed | Current advances on the therapeutic potential of pinocembrin: An updated review |
| title_short | Current advances on the therapeutic potential of pinocembrin: An updated review |
| title_sort | current advances on the therapeutic potential of pinocembrin an updated review |
| topic | Pinocembrin Biosynthesis Pharmacological activities Pharmacokinetics Gut microbiota Clinical trials |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222014214 |
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